LMW Heparin: Relationship Between Antithrombotic and Anticoagulant Effects

  • T. W. Barrowcliffe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 313)

Abstract

LMW heparin is now becoming a well established alternative to unfractionated heparin (UFH), particularly for the prophylaxis of deep vein thrombosis, where the convenience of a single injection a day, instead of two or three as for UFH, is a decided advantage. Whilst the mechanisms of the anticoagulant actions of heparin and LMW heparin at the molecular level are now well understood, there is still some uncertainty and controversy over the mechanisms of their antithrombotic effect in vivo, and in particular about the relevance of the various in vitro anticoagulant assays to their in vivo actions.

Keywords

Saccharide Lipase Heparin Polysaccharide Fractionation 

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • T. W. Barrowcliffe
    • 1
  1. 1.National Institute for Biological Standards and ControlPotters BarUK

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