Synthetic Thrombin Inhibitors as Anticoagulants Pharmacological Aspects

  • F. Markwardt
  • J. Hauptmann
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 340)


Thromboembolic disorders are a major cause of morbidity and mortality in industrialized countries. For prophylaxis of thrombosis at present the so-called indirect anticoagulants of the dicoumarol type, the biopolymer heparin and several antiplatelet drugs are used. The active principle of the medicinal leech, hirudin, is available now as a recombinant product and is being tested clinically. Each of the mentioned anticoagulants has its values and limitations, based either on the chemical nature or on the mode of action. Antithrombotic regimes that do not interfere with the coagulation system are proposed; their value, however, has not yet been fully documented.


Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Antithrombotic Effect Synthetic Inhibitor Amniotic Fluid Embolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • F. Markwardt
    • 1
  • J. Hauptmann
    • 1
  1. 1.Institute of Pharmacology and ToxicologyMedical Academy ErfurtFederal Republic of Germany

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