Pharmacological Studies of Novel Marine Metabolites
Fundamental to the complex process associated with drug discovery is the establishment of a carefully defined collaborative relationship between academic bioorganic chemists and cellular or molecular pharmacologists. We mention this as a new emerging direction in research that should be particularly emphasized in an academic setting. The collaborative goal of the academic chemists and pharmacologists should be to contribute in some specific way to the advancement of each other’s science. Educational goals are not served well through routine programs for isolating and screening natural products. Screening programs of this kind are well developed in U.S. and foreign drug companies. In fact, new molecular receptor assays that allow a wide variety and large number of screens to be executed rapidly are becoming available. Academic pharmacologists have the responsibility to develop knowledge fundamental to advancing biomedical science by using bioactive substances as probes to better understand normal and pathological biological processes, to define in rigorous fashion the properties of these probes, and to determine their biochemical limitations and how they can be used properly and safely.
KeywordsArachidonic Acid Phorbol Myristate Acetate Cytochrome P450 Enzyme Phorbol Myristate Acetate Arachidonic Acid Metabolism
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