Skip to main content
SpringerLink
Log in

The Controlled Release of 5-Fluorouracil from Acrylate Copolymers of 1-(N-2-Ethylmethacrylcarbamoyl)-5-Fluorouracil Monomer

  • Chapter
Polymeric Materials in Medication

Part of the book series: Polymer Science and Technology ((POLS,volume 32))

Abstract

The preparation, polymerization and copolymerization of a novel methacrylate type monomer containing 5-fluorouracil is described. The methyl and butyl acrylate copolymers show zero order release behavior, and can deliver a constant level of 5-fluorouracil for time periods greater than 240 hours. These zero order release profiles were obtained without any special membranes or device designs, and were characteristic of the polymeric material itself.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. G. Gregoriadis, ed., “Liposome Technology”, Vols. I, II, III, CRC Press, Boca Raton, FL, 1984.

    Google Scholar 

  2. C. G. Gebelein in “Biological Activities of Polymers”, C. E. Carraher, Jr. & C. G. Gebelein, eds., Amer. Chem. Soc. Symp., No. 186, Washington, DC, 1982, p. 193.

    Google Scholar 

  3. C. G. Gebelein, R. M. Morgan, R. Glowacky & W. Baig in “Biomedical and Dental Applications of Polymers”, C. G. Gebelein & F. F. Koblitz, eds., Plenum, New York, 1981, p. 191

    Google Scholar 

  4. H. G. Batz, Adv. Polymer Sci., 23 25, Springer-Verlag, New York, 1977.

    Google Scholar 

  5. H. Ringsdorf, J. Polymer Sci., Symp. 51, 135 (1975).

    Google Scholar 

  6. L. G. Donaruma, R. M. Ottenbrite, & O. Vogl, eds., “Anionic Polymeric Drugs”, Wiley-Interscience, New York, 1980.

    Google Scholar 

  7. H. Ballweg, D. Schmael & E. von Wedelstaedt, Arzneim. Forsch., 19, 1296 (1969).

    Google Scholar 

  8. Z.-H. Liu, “27th International Symposium on Macromolecules”, Strasbourg, France, 1981, p. 1335.

    Google Scholar 

  9. Z.-H. Liu, J. Wuhan U. (PRC), Nat. Sci. Ed., 3, 114 (1983).

    Google Scholar 

  10. C. G. Gebelein & R. M. Morgan, Polymer Preprints, 18 (1), 811 (1977).

    Google Scholar 

  11. P. P. Umrigar, S. Ohashi & G. B. Butler, J. Polym. Sci., Chem. Ed., 17, 351 (1979).

    Article  Google Scholar 

  12. J. L. Alderfer, R. E. Loomis & T. J. Zielinski, Biochemistry, 21, 2738 (1982).

    Article  Google Scholar 

  13. M. Yoshida, M. Kumakura & I. Kaetsu, Polymer J., 11, 775 (1979).

    Article  Google Scholar 

  14. I. Kaetsu, M. Yoshida, M. Kumakura, A. Yamada & Y. Sakurai, Biomaterials, 1, 17 (1980).

    Article  Google Scholar 

  15. I. Kaetsu, M. Yoshida & A. Yamada, J. Biomed. Mater. Res., 14, 185 (1980).

    Article  Google Scholar 

  16. C. G. Gebelein, R. M. Morgan & R. Glowacky, Polymer Preprints, 18 (2), 513 (1977).

    Google Scholar 

  17. C. G. Gebelein & M. W. Baig, Polymer Preprints, 19 (1), 543 (1978).

    Google Scholar 

  18. W. Baig & C. G. Gebelein in: “Controlled Release of Bioactive Materials, 8th Internat. Symp.”, S. Z. Mansdorf & T. J. Roseman, eds., Controlled Release Society, 1981, p. 170.

    Google Scholar 

  19. C. G. Gebelein, Org. Coatings & Plastics Chem., 42, 422 (1980).

    Google Scholar 

  20. C. G. Gebelein, W. Baig, R. M. Morgan & R. Glowacky, Trans. Soc. Biomaterials, 5, (1982).

    Google Scholar 

  21. C. G. Gebelein, Proc. Polym. Mat. Sci. Eng., 51, 127 (1984).

    Google Scholar 

  22. R. R. Hartsough & C. G. Gebelein, Proc. Polym. Mat. Sci. Eng., 51, 131 (1984).

    Google Scholar 

  23. M. Yoshida, M. Kumakura & I. Kaetsu, Polymer, 19, 1375 (1978).

    Article  Google Scholar 

  24. Y. W. Chien, H. J. Lambert & D. E. Grant, J. Pharm. Sci., 63 (3), 365 (1974).

    Article  Google Scholar 

  25. K. G. Nelson & A. C. Shah, J. Pharm. Sci., 64 (4), 610 (1975).

    Article  Google Scholar 

  26. M. Yoshida, M. Kumakura & I. Kaetsu, J. Pharm. Sci., 68, 628 (1979).

    Article  Google Scholar 

  27. M. Yoshida, M. Kumakura & I. Kaetsu, J. Pharm. Sci., 68, 860 (1979).

    Article  Google Scholar 

  28. T. Seita, M. Kinoshita & M. Imoto, J. Macromol. Sci.-Chem., A7, 1297 (1973).

    Google Scholar 

  29. S. Hoffman, W. Witkowski & H. Schubert, Z. Chem., 14, 14 (1974).

    Article  Google Scholar 

  30. T. Higuchi, J. Pharm. Sci., 50, 824 (1961).

    Google Scholar 

  31. S. W. Kim, R. V. Petersen & J. Feijen, in: “Drug Design” Vol. 10, E. J. Ariens, ed., Academic Press, New York, 1980, p. 193.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Chemistry, Youngstown State University, Youngstown, OH, 44555, USA

    Robert R. Hartsough & Charles G. Gebelein

Authors
  1. Robert R. Hartsough
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Charles G. Gebelein
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Youngstown State University, Youngstown, Ohio, USA

    Charles G. Gebelein

  2. Florida Atlantic University, Boca Raton, Florida, USA

    Charles E. Carraher Jr.

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer Science+Business Media New York

About this chapter

Cite this chapter

Hartsough, R.R., Gebelein, C.G. (1985). The Controlled Release of 5-Fluorouracil from Acrylate Copolymers of 1-(N-2-Ethylmethacrylcarbamoyl)-5-Fluorouracil Monomer. In: Gebelein, C.G., Carraher, C.E. (eds) Polymeric Materials in Medication. Polymer Science and Technology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2245-8_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-2245-8_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-2247-2

  • Online ISBN: 978-1-4899-2245-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation