Abstract
Recent work from our laboratory has provided evidence which suggests that mitochondrial disorganization may be an important aspect of age related changes of fixed postmitotic cells such as those found in the adult insect Drosophila melanogaster (Miguel et al., 1979; Fleming et al., 1982). For example, increased mitochondrial respiration in insects exposed to moderately high temperature results in both higher rates of lipopigment accumulation and life shortening (Miquel et al., 1976). Moreover, adult Drosophila showing lower respiration rates because of exposure to the mitochondrial DNA-intercalating dye ethidium bromide in their diet during development live longer than controls raised on normal medium (Fleming et al., 1981). Also, there is an inverse correlation between oxygen consumption and life span in flies treated with high levels of dietary antioxidants (Miquel et al., 1982). More recently, we have confirmed this inverse relationship for several strains of Drosophila raised under identical conditions (Miquel et al., 1985). Collectively, the above results which are shown in Fig. 1 provide strong support for the concept that respiration rate is a critical determinant of the lifespan in this organism.
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Fleming, J.E., Miquel, J., Bensch, K.G. (1985). Age Dependent Changes in Mitochondria. In: Woodhead, A.D., Blackett, A.D., Hollaender, A. (eds) Molecular Biology of Aging. Basic Life Sciences, vol 35. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2218-2_7
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DOI: https://doi.org/10.1007/978-1-4899-2218-2_7
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