Abstract
The intoxication of an organism with insecticide involves a variety of steps and reactions (Narahashi, 1971a). The uptake of insecticide is the first step to occur, and a number of factors such as lipid solubility and vapor pressure of insecticide are related to this process (Chapter 1). The insecticide that has entered the body is then transported to various organs and may undergo a variety of biotransformations in which it is either converted into a more potent compound or degraded to one which is relatively nontoxic (Chapters 2, 4, and 5). The active form of the insecticide eventually reaches its target site and exerts effects characteristic of the insecticide and the tissue concerned.
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References
Akkermans, L. M. A., van den Bercken, J., van der Zalm, J. M., and van Straaten, H. W. M., 1974, Effects of dieldrin (HEOD) and some of its metabolites on synaptic transmission in the frog motor end-plate, Pestic. Biochem. Physiol. 4:313. Becht, G., 1958, Influence of DDT and lindane on chordotonal organs in the cockroach, Nature (London) 181:777.
Brooks, G. T., and Harrison, A., 1969, Hydration of HEOD (dieldrin) and the heptachlor epoxides by microsomes from the liver of pigs and rabbits, Bull. Environ. Contam. Toxicol. 4:352.
Brooks, G. T., Harrison, A., and Lewis, S. E., 1970, Cyclodiene epoxide ring hydration by microsomes from mammalian liver and houseflies, Biochem. Pharmacol. 19:255.
Burt, P. E., and Goodchild, R. E., 1971a, The site of action of pyrethrin I in the nervous system of the cockroach Periplaneta americana L., Entomol. Exp. Appl. 14:179.
Burt, P. E., and Goodchild, R. E., 1971b, The spread of topically-applied pyrethrin I from the cuticle to the central nervous system of the cockroach Periplaneta americana, Entomol. Exp. Appl. 14:255.
Camougis, G., and Davis, W. M., 1971, A comparative study of the neuropharmacological basis of action of pyrethrin, Pyrethrum Post 11:7.
Chiba, S., Saji, Y., Takeo, Y., Yui, T., and Aramaki, Y., 1967, Nereistoxin and its derivatives, their neuromuscular blocking and convulsive actions, J.J. Pharmacol. 17:491.
Deguchi, T., and Narahashi, T., 1971, Effects of procaine on ionic conductances of end-plate membranes, J. Pharmacol. Exp. Ther. 176:423.
Deguchi, T., Narahashi, T., and Haas, H. G., 1971, Mode of action of nereistoxin on the neuromuscular transmission in the frog, Pestic. Biochem. Physiol. 1:196.
Dresden, D., 1949, Physiological Investigations into the Action of DDT, Drukkerij en Uitgeverij, G. W. Van der Wiel and Co., Arnhem, Netherlands.
Eaton, J. L., and Sternburg, J., 1964, Temperature and the action of DDT on the nervous system of Periplaneta americana (L), J. Insect Physiol. 10:471.
Frazier, D. T., Narahashi, T., and Yamada, M., 1970, The site of action and active form of local anesthetics. II. Experiments with quaternary compounds, J. Pharmacol. Exp. Ther. 171:45.
Frazier, D. T., Sevcik, C., and Narahashi, T., 1973, Nicotine: Effect on nerve membrane conductances, Eur. J. Pharmacol. 22:217.
Gage, P. W., and Armstrong, C. M., 1968, Miniature end-plate currents in voltage-clamped muscle fibres, Nature (London) 218:363.
Gordon, H. T., and Welsh, J. H., 1948, The role of ions in axon surface reactions to toxic organic compounds, J. Cell. Comp. Physiol. 31:395.
Hille, B., 1968, Pharmacological modifications of the sodium channels of frog nerve, J. Gen. Physiol. 51:199.
Hodgkin, A. L., and Huxley, A. F., 1952, A quantitative description of membrane current and its application to conduction and excitation in nerve, J. Physiol. (London) 117:500.
Kordas, M., 1970, The effect of procaine on neuromuscular transmission, J. Physiol. (London) 209:689.
Korte, F., 1967, Metabolism of 14C-labelled insecticides in microorganisms, insects, and mammals, Botyu-Kagaku 32:46.
Korte, F., and Arent, H., 1965, Metabolism of insecticides 1X(1). Isolation and identification of dieldrin metabolites from urine of rabbits after oral administration of dieldrin-14C, Life Sci. 4:2017.
Korte, F., and Kochen, W., 1966, Insektizide in Stoffwechsel. XII. Isolierung und Identifizierung von Metaboliten des Aldrom-14C aus dem Urin von Kaninchen, Med. Pharmacol. Exp. 15:409.
Lalonde, D. I. V., and Brown, A. W. A., 1954, The effect of insecticides on the action potentials of insect nerve, Can. J. Zool. 32:74.
Langley, J. N., 1901, On the stimulation and paralysis of nerve-cells and of nerve ending. Part I, J. Physiol. (London) 27:224.
Langley, J. N., and Dickinson, W. L., 1889, On the local paralysis of peripheral ganglia, and on the connexion of different classes of nerve fibres with them, Proc. Roy. Soc. 46:423.
Lowenstein, O., 1942, A method of physiological assay of pyrethrum extract, Nature (London) 150:760.
Maeno, T., 1966, Analysis of sodium and potassium conductances in the procaine end-plate potential, J. Physiol. (London) 183:592.
Maeno, T., Edwards, C., and Hashimura, S., 1971, Difference in effects on end-plate potentials between procaine and lidocaine as revealed by voltage-clamp experiments, J. Neurophysiol. 34:32.
Matthews, H. B., and Matsumura, F., 1969, Metabolic fate of dieldrin in the rat, J. Agr. Food Chem. 17:845.
Murayama, K., Abbott, N. J., Narahashi, T., and Shapiro, B. I., 1972, Effects of allethrin and Condylactis toxin on the kinetics of sodium conductance of crayfish axon membranes, Comp. Gen. Pharmacol. 3:391.
Nagawa, Y., Saji, Y., Chiba, S., and Yui, T., 1971, Neuromuscular blocking actions of nereistoxin and its derivatives and antagonism by sulfhydryl compounds, Jpn. J. Pharmacol. 21:185.
Narahashi, T., 1962a, Effect of the insecticide allethrin on membrane potentials of cockroach giant axons, J. Cell. Comp. Physiol. 59:61.
Narahashi, T., 1962b, Nature of the negative after-potential increased by the insecticide allethrin in cockroach giant axons, J. Cell. Comp. Physiol. 59:67.
Narahashi, T., 1964, Insecticide resistance and nerve sensitivity, Jpn. J. Med. Sci. Biol. 17:46.
Narahashi, T., 1966, Mode of action of insecticides, Kagaku To Seibutsu (Chemistry and Biology) 4:134.
Narahashi, T., 1969, Mode of action of DDT and allethrin on nerve: Cellular and molecular mechanisms, Residue Rev. 25:275.
Narahashi, T., 1971a, Effects of insecticides on excitable tissues, in: Advances in Insect Physiology, Vol. 8 (J. W. L. Beament, J. E. Treherne, and V. B. Wigglesworth, eds.), pp. 1–93, Academic Press, New York.
Narahashi, T., 1971b, Mode of action of pyrethroids, Bull. WHO 44:337.
Narahashi, T., 1972, Mechanism of action of tetrodotoxin and saxitoxin on excitable membranes, Fed. Proc. 31:1124.
Narahashi, T., 1973, Mode of action of nereistoxin on excitable tissues, in: Marine Pharmacognosy: Action of Marine Biotoxins at the Cellular Level (D. F. Martin and G. M. Padilla, eds.), pp. 107–126, Academic Press, New York.
Narahashi, T., 1974, Nerve membrane as a target of pyrethroids, in: 3rd Int. Congr. Pestic. Chem., Helsinki, Abst. No. 349.
Narahashi, T., and Anderson, N. C., 1967, Mechanism of excitation block by the insecticide allethrin applied externally and internally to squid giant axons, Toxicol. Appl. Pharmacol. 10:529.
Narahashi, T., and Frazier, D. T., 1971, Site of action and active form of local anesthetics, in: Neurosciences Research, Vol. 4 (S. Ehrenpreis and O. C. Salnitzky, eds.), pp. 65–99, Academic Press, New York.
Narahashi, T., and Haas, H. G., 1967, DDT: Interaction with nerve membrane conductance changes, Science (N.Y.) 157:1438.
Narahashi, T., and Haas, H. G., 1968, Interaction of DDT with the components of lobster nerve membrane conductance, J. Gen. Physiol. 51:177.
Narahashi, T., and Yamasaki, T., 1960a, Mechanism of the after-potential production in the giant axons of the cockroach, J. Physiol. (London) 151:75.
Narahashi, T., and Yamasaki, T., 1960b, Mechanism of increase in negative after-potential by dicophane (DDT) in the giant axons of the cockroach, J. Physiol. (London) 152:122.
Narahashi, T., and Yamasaki, T., 1960c, Behaviors of membrane potential in the cockroach giant axons poisoned by DDT, J. Cell. Comp. Physiol. 55:131.
Narahashi, T., Moore, J. W., and Scott, W. R., 1964, Tetrodotoxin blockage of sodium conductance increase in lobster giant axons, J. Gen. Physiol. 47:965.
Narahashi, T., Frazier, D. T., and Yamada, M., 1970, The site of action and active form of local anesthetics. I. Theory and pH experiments with tertiary compounds, J. Pharmacol. Exp. Ther. 171:32.
Nitta, S., 1941, Pharmakalogische Untersuchung des Nereistoxins, das vom Verf. im Körper des Lumbriconereis heteropoda (Isome) isoliert wurde, Tokyo Igaku Zasshi 55:285.
Okaichi, T., and Hashimoto, Y., 1962, The structure of nereistoxin, Agr. Biol Chem. 26:224.
Roeder, K. D., and Weiant, E. A., 1946, The site of action of DDT in the cockroach, Science (N. Y.) 103:304.
Roeder, K. D., and Weiant, E. A., 1948, The effect of DDT on sensory and motor structures in the cockroach leg, J. Cell. Comp. Physiol. 32:175.
Roeder, K. D., and Weiant, E. A., 1951, The effect of concentration, temperature and washing on the time of appearance of DDT-induced trains in sensory fibers of the cockroach, Ann. Entomol. Soc. Am. 44:372.
Sakai, M., 1966, Studies on the insecticidal action of nereistoxin, 4-N, N-dimethylamino-l,2-dithiolane. III. Antagonism to acetylcholine in the contraction of rectus abdominis muscle of frog, Botyu-Kagaku 31:61.
Sakai, M., 1967, Studies on the insecticidal action of nereistoxin, 4-N, N-dimethylamino-l,2-dithiolane. V. Blocking action on the cockroach ganglion, Botyu-Kagaku 32:21.
Sakai, M., 1969, Nereistoxin and cartap: Their mode of action as insecticides, Rev. Plant Protection Res. 2:17.
Sakai, M., and Sato, Y., 1971, Metabolic conversion of the nereistoxin related compounds into nereistoxin as a factor of their insecticidal action, in: Abstr. 2nd Int. Congr. Pestic. Chem., Tel Aviv, February.
Schallek, W., and Wiersma, C. A. G., 1948, The Influence of various drugs on a crustacean synapse, J. Cell. Comp. Physiol. 31:35.
Shanes, A. M., 1949a, Electrical phenomena in nerve. I. Squid giant axons, J. Gen. Physiol. 33:57.
Shanes, A. M., 1949b, Electrical phenomena in nerve. II. Crab nerve, J. Gen. Physiol. 33:75.
Shanes, A. M., 1951, Electrical phenomena in nerve. III. Frog sciatic nerve, J. Cell. Comp. Physiol. 38:17.
Shankland, D. L., and Schroeder, M. E., 1973, Pharmacological evidence for a discrete neurotoxic action of dieldrin (HEOD) in the American cockroach, Periplaneta americana (L.), Pestic. Biochem. Physiol. 3:77.
Thesleff, S., 1955, The mode of neuromuscular block by acetylcholine, nicotine, decamethonium and succinylcholine, Acta Physiol. Scand. 34:218.
van den Bercken, J., 1968, The action of DDT and dieldrin on nerves and muscles of Xenopus laevis, Meded. Rijksfak, Landbouw-Wetenschappen Gent. 33:1241.
van den Bercken, J., and Narahashi, T., 1974, Effects of aldrin-transdiol, a metabolite of the insecticide dieldrin, on nerve membrane, Eur. J. Pharmacol. 27:255.
Wang, C. M., and Narahashi, T., 1972, Mechanism of dual action of nicotine on end-plate membranes, J. Pharmacol. Exp. Ther. 182:427.
Wang, C. M., Narahashi, T., and Yamada, M., 1971, The neurotoxic action of dieldrin and its derivatives in the cockroach, Pestic. Biochem. Physiol. 1:84.
Wang, C. M., Narahashi, T., and Scuka, M., 1972, Mechanism of negative temperature coefficient of nerve blocking action of allethrin, J. Pharmacol. Exp. Ther. 182:442.
Welsh, J. H., and Gordon, H. T., 1947, The mode of action of certain insecticides on the arthropod nerve axon, J. Cell. Comp. Physiol. 30:147.
Yamasaki, T., and Ishii, T. (Narahashi, T.), 1952a, Studies on the mechanism of action of insecticides (IV). The effects of insecticides on the nerve conduction of insect, Oyo-Kontyu 7:157.
Yamasaki, T., and Ishii, T. (Narahashi, T.), 1952b, Studies on the mechanism of action of insecticides (V). The effects of DDT on the synaptic transmission in the cockroach, Oyo-Kontyu 8:111.
Yamasaki, T., and Ishii, T. (Narahashi, T.,), 1954a, Studies on the mechanism of action of insecticides (VII). Activity of neuron soma as a factor of development of DDT symptoms in the cockroach, Botyu-Kagaku 19:1. English translation (1957), in: Japanese Contributions to the Study of the Insecticide-Resistance Problem, pp. 140-154, published by Kyoto University for WHO.
Yamasaki, T., and Ishii, T. (Narahashi, T.), 1954b, Studies on the mechanism of action of insecticides (VIII). Effects of temperature on the nerve susceptibility to DDT in the cockroach Botyu-Kagaku 19:39. English translation (1957), in: Japanese Contributions to the Study of the Insecticide-Resistance Problem, pp. 155-162, published by Kyoto University for WHO.
Yamasaki, T., and Ishii, T. Narahashi, T., 1954c, Studies on the mechanism of action of insecticides (IX). Repetitive excitation of the insect neuron soma by direct current stimulation and effects of DDT, Jpn. J. Appl. Zool. 19:16.
English translation (1957), in: Japanese Contributions to the Study of the Insecticide-Resistance Problem, pp. 163-175, published by Kyoto University for WHO.
Yamasaki, T., and Narahashi, T., 1957, Intracellular microelectrode recordings of resting and action potentials from the insect axon and the effects of DDT on the action potential: Studies on the mechanism of action of insecticides (XIV), Botyu-Kagaku 22:305.
Yamasaki, T., and Narahashi, T., 1958a, Nervous activity as a factor of development of dieldrin symptoms in the cockroach: Studies on the mechanism of action of insecticides (XVI), Botyu-Kagaku 23:47.
Yamasaki, T., and Narahashi, T., 1958b, Resistance to houseflies to insecticides and the susceptibility nerve to insecticides: Studies on the mechanism of action of insecticides (XVII), Botyu-Kagaku 23:146.
Yamasaki, T., and Narahashi, T., 1962, Nerve sensitivity and resistance to DDT in houseflies, Jpn. J. Appl Entomol. Zool. 6:293.
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Narahashi, T. (1976). Effects of Insecticides on Nervous Conduction and Synaptic Transmission. In: Wilkinson, C.F. (eds) Insecticide Biochemistry and Physiology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2212-0_9
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DOI: https://doi.org/10.1007/978-1-4899-2212-0_9
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