Insecticides as Inhibitors of Respiration

  • Jun-ichi Fukami


Under aerobic conditions, the energy required by the tissue cell is provided mainly by respiration, which refers to oxidation of the biological fuel molecules by molecular oxygen. The many chemical steps involved in respiration and in the subsequent conservation of the derived energy in the form of ATP are catalyzed by numerous species of enzymes. These do not occur in soluble form in the cytoplasm of the cell but are located exclusively in the mitochondria, which are considered to be the energy-generating sites of the cell.


Respiratory Chain Flight Muscle Pyridine Nucleotide Musca Domestica Muscle Mitochondrion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Abo-Khatwa, N., and Hollingworth, R. M., 1972, Chlorodimeform: The relation of mitochondrial uncoupling to toxicity in the German cockroach, Life Sci. (Part II) 11:1181.Google Scholar
  2. Aldridge, W. N., and Street, R. W., 1970, Oxidative phosphorylation: The specific binding of trimethyltin and triethyltin to rat liver mitochondria, Biochem. J. 118:171.PubMedGoogle Scholar
  3. Anderson, A. D., March, R. B., and Metcalf, R. L., 1954, Inhibition of the succinoxidase system of susceptible and resistant houseflies by DDT and related compounds, Ann. Entomol. Soc. Am. 47:595.Google Scholar
  4. Avi-Dor-Dor, Y., and Gonda, O., 1959, Studies on the adenosine triphosphate-phosphate exchange and the hydrolysis of adenosine triphosphate catalyzed by a particulate fraction from the mosquito, Biochem J. 72:8.Google Scholar
  5. Barsa, M. C., and Ludwig, D., 1959, Effects of DDT on the respiratory enzymes of the mealworm, Tenebrio molitor (L.), and of the housefly, Musca domestica (L.), Ann. Entomol. Soc. Am. 52:179.Google Scholar
  6. Birt, L. M., 1961, Flight-muscle mitochondria of Lucilia cuprina and Musca domestica: Estimation of the pyridine nucleotide content and of the response of respiration to adenosine diphosphate, Biochem. J. 80:623.PubMedGoogle Scholar
  7. Bode, C., and Klingenberg, M., 1964, Carnitine and fatty acid oxidation in mitochondria of various organs, Biochim. Biophys. Acta 84:93.PubMedGoogle Scholar
  8. Brosemer, R. W., and Marquardt, R. R., 1966, Insect extramitochondrial glycerophosphate dehydrogenase. II. Enzymic properties and amino acid composition of the enzyme from honey bee (Apis mellifera) thoraces, Biochim Biophys. Acta 128:464.Google Scholar
  9. Brown, R. E., and Brown, A. W. A., 1956, The effects of insecticidal poisoning on the level of cytochrome oxidase in the American cockroach, J. Econ. Entomol. 49:675.Google Scholar
  10. Bruce, A. L., and Banks, W. M., 1973, Metabolism of muscle of cockroach Blaberus gigantens, Ann. Entomol. Soc. Am. 66:1209.Google Scholar
  11. Bulos, B., Shukla, S., and Sacktor, B., 1972, Bioenergetic properties of mitochondria from flight muscle of aging blow flies, Arch. Biochem. Biophys. 149:461.PubMedGoogle Scholar
  12. Burgos, J., and Redfearn, E. R., 1965, The inhibition of mitochondrial reduced nicotinamideadenine dinucleotide oxidation by rotenoids, Biochim. Biophys. Acta 110:475.Google Scholar
  13. Casida, J. E., 1973, Insecticide biochemistry, Ann. Rev. Biochem. 42:259.PubMedGoogle Scholar
  14. Chan, S. K., and Margoliash, E., 1966, Properties and primary structure of the cytochrome c from the flight muscles of the moth, Samia cynthia, J. Biol. Chem. 241:335.Google Scholar
  15. Chance, B., and Hess, B., 1959, Metabolic control mechanisms. I. Electron transfer in the mammalian cell, J. Biol. Chem. 234:2402.Google Scholar
  16. Chance, B., and Sacktor, B., 1958, Respiratory metabolism of insect flight muscle. II. Kinetics of respiratory enzymes in flight muscle sarcosomes, Arch. Biochem. Biophys. 76:509.PubMedGoogle Scholar
  17. Chance, B., and Williams, G. R., 1955a, Respiratory enzymes in oxidative phosphorylation. III. The steady state, J. Biol Chem. 217:409.PubMedGoogle Scholar
  18. Chance, B., and Williams, G. R., 1955b, Respiratory chain and oxidative phosphorylation. IV. The respiratory chain, J. Biol. Chem. 217:429.PubMedGoogle Scholar
  19. Chance, B., and Williams, G. R., 1956, The respiratory chain and oxidative phosphorylation, Advan. Enzymol. 17:65.Google Scholar
  20. Chefurka, W., 1958, On the importance of α-glycerophosphate dehydrogenase in glycolyzing insect muscle, Biochim. Biophys. Acta 28:660.PubMedGoogle Scholar
  21. Chefurka, W., 1965, Some comparative aspects of the metabolism of carbohydrate in insect, Ann. Rev. Entomol. 10:345.Google Scholar
  22. Childress, C. C., and Sacktor, B., 1966, Pyruvate oxidation and the permeability of mitochondria from blowfly flight muscle, Science 154:268.PubMedGoogle Scholar
  23. Chino, H., 1963, Respiratory enzyme system of the Bombyx silkworm egg in relation to the mechanism of the formation of sugar alchols, Arch. Biochem. Biophys. 102:400.PubMedGoogle Scholar
  24. Chino, H., and Harano, T., 1966, The significance of 3-hydroxykynurenine for the NADH, NADPH-cytochrome c reductase which exists in soluble fraction, Seikagaku 38:675.Google Scholar
  25. Cochran, D. G., 1963, Respiratory control in cockroach-muscle mitochondria, Biochim. Biophys. Acta 78:393.PubMedGoogle Scholar
  26. Conover, T. E., and Ernster, L., 1960, By-pass of the amytal-sensitive site of the respiratory chain in mitochondria by means of vitamin K3, Acta Chem. Scand. 14:1840.Google Scholar
  27. Conover, T. E., and Ernster, L., 1962, DT diaphorase. II. Relation to respiratory chain of intact mitochondria, Biochim. Biophys. Acta 58:189.PubMedGoogle Scholar
  28. Conover, T. E., and Ernster, L., 1963, DT diaphorase. IV. Coupling of extramitochondrial reduced pyridine nucleotide oxidation to mitochondrial respiratory chain, Biochim. Biophys. Acta 67:268.PubMedGoogle Scholar
  29. Conover, T. E., Danielson, L., and Ernster, L., 1963, DT diaphorase. III. Separation of mitochondrial DT diaphorase and respiratory chain, Biochim. Biophys. Acta 67:254.PubMedGoogle Scholar
  30. Corbett, J. R., and Wright, B. J., 1970, Uncoupling of oxidative phorphorylation in intact mites and in isolated mite mitochondria by a new acaricide, 5,6-dichloro-l-phenyoxycarbonyl-2-trifluromethylbenzimidazole, Biochem. J. 118:50.Google Scholar
  31. Davis, R. A., and Fraenkel, G., 1940, The oxygen consumption of flies during flight, J. Exp. Biol. 17:402.Google Scholar
  32. De Kort, C. A. D., Bartelink, A. K. M., and Schuurmans, R. R., 1973, The significance of l-proline for oxidative metabolism in the flight muscles of the Colorado beetle, Leptinotarsa decemlineata, Insect Biochem. 3:11.Google Scholar
  33. Dixon, M., and Webb, E. C., 1964, Enzymes, Longmans Green, London.Google Scholar
  34. Donnellan, J. F., and Beechey, R. B., 1969, Factors, affecting the oxidation of glycerol-1-phosphate by insect flight muscle mitochondria, J. Insect Physiol. 15:367.PubMedGoogle Scholar
  35. Donnellan, J. F., Barker, M. D., Wood, J., and Beechey, R. B., 1970, Specificity and locale of the L-3-glycerophosphate-flavoprotein oxidoreductase mitochondria isolated from the flight muscle of Sacophaga barbata, Biochem. J. 120:467.PubMedGoogle Scholar
  36. Dummel, R. J., and Kun, E., 1969, Studies with specific enzyme inhibitors. XII. Resolution of dl-erythro-fluorocitric acid into optically active isomers, J. Biol. Chem. 244:2966.PubMedGoogle Scholar
  37. Eanes, R. Z., Skilleter, D. N., and Kun, E., 1972, Inactivation of the tricarboxylate carrier of liver mitochondria by (-)-erythrofluorocitrate, Biochem. Biophys. Res. Commun. 46:1618.PubMedGoogle Scholar
  38. Ela, R., Chefurka, W., and Robinson, J. B., In vivo glucose metabolism in the normal and poisoned cockroach, Periplaneta americana, J. Insect Physiol. 16:2137.Google Scholar
  39. Ernster, L., and Navazio, F., 1958, Soluble diaphorase in animal tissues, Acta Chem. Scand. 12:595.Google Scholar
  40. Ernster, L., Ljunggren, M., and Danielson, L., 1960, Purification and some properties of a highly dicumarol-sensitive liver diaphorase, Biochem. Biophys. Res. Commun. 2:88.Google Scholar
  41. Ernster, L., Danielson, L., and Ljunggren, M., 1962, DA diaphorase. I. Purification from the soluble fraction of rat-liver cytoplasm, and properties, Biochim. Biophys. Acta 58:171.PubMedGoogle Scholar
  42. Estabrook, R. W., 1967, Mitochondrial respiratory control and the polarographic measurement of ADP:O ratios, in: Methods in Enzymology, Vol. 10 (R. E. Estabrook, and M. F. Pullman, eds.), p. 41, Academic Press, New York.Google Scholar
  43. Estabrook, R. W., and Sacktor, B., 1958, α-Glycerophosphate oxidase of flight muscle mitochondria, J. Biol. Chem. 233:1014.PubMedGoogle Scholar
  44. Fukami, J., 1954, Effect of rotenone on the succinoxidase system in the muscle of the cockroach, Jpn. J. Appl. Zool. 19:29.Google Scholar
  45. Fukami, J., 1955, Effect of rotenone on respiration in the muscle of the cockroach, Periplaneta americana L., Jpn. J. Appl. Zool. 19:148.Google Scholar
  46. Fukami, J., 1956, Effect of some insecticides on the respiration of insect organs, with special reference to the effects of rotenone, Botyukagaku 21:122.Google Scholar
  47. Fukami, J., 1957, Studies on red and white muscle of insect, Ins. Insect Contrib., Kyoto Univ. WHO, p. 217.Google Scholar
  48. Fukami, J., 1961, Effect of rotenone on the respiratory enzyme system of insect muscle, Bull. Natl. Inst.Agr. Sci. C 13:33.Google Scholar
  49. Fukami, J., and Nakatsugawa, T., 1961, Studies on red and white muscles of insects with special reference to spectrophotometric observation of cytochromes in muscles, Bull. Natl. Inst. Agr. Sci. C 13:47.Google Scholar
  50. Fukami, J., and Tomizawa, C., 1956, Effects of rotenone on the l-glutamic oxidase system in the insect, Botyu-Kagaku 21:129.Google Scholar
  51. Fukami, J., and Tomizawa, C., 1958, The effects of rotenone and its derivatives on the respiration of brain in guinea pig, Botyu-Kagaku 23:205.Google Scholar
  52. Fukami, J., Nakatsugawa, T., and Narahashi, T., 1959, The relation between chemical structure and toxicity in rotenone derivatives, Jpn. J. Appl. Entomol. Zool 3:259.Google Scholar
  53. Fukami, J., Shishido, T., Fukunaga, K., and Casida, J. E., 1969, Oxidative metabolism of rotenone in mammals, fish and insects and its relation to selective toxicity, J. Agr. Food. Chem. 17:1217.Google Scholar
  54. Fukami, J., Mitsui, T., Fukunaga, and Shishido, T., 1970, The selective toxicity of rotenone between mammals, fish and insects, in: Biochemical Toxicology of Insecticides (R. D. O’Brien and I. Yamamoto, eds.), pp. 159–178, Academic Press, New York.Google Scholar
  55. Gonda, O., Traub, A., and Avi-Dor, Y., 1957, The oxidative activity of a particulate fraction from mosquitos, Biochem. J. 67:487.PubMedGoogle Scholar
  56. Gregg, C. T., Heisler, C. R., and Remmert, L. F., 1960, Oxidative phosphorylation and respiratory control in housefly mitochondria, Biochim. Biophys. Acta 45:561.PubMedGoogle Scholar
  57. Gutman, M., Singer, T. P., Beinert, H., and Casida, J. E., 1970, Reaction sites of rotenone, piericidin A, and amytal in relation to the nonhem ion components of NADH dehydrogenase, Proc. Natl. Acad. Sci. U.S.A. 65:763.PubMedGoogle Scholar
  58. Gutman Coles, C. J., Singer, T. P., and Casida, J. E., 1971, On the functional organization of the respiratory chain at the dehydrogenase-coenzyme Q junction, Biochemistry 10 (11):2036.Google Scholar
  59. Hagihara, B., 1965, Measurement of respiration with polarography, Protein Nucleic Acid Enzyme 10:1689.Google Scholar
  60. Hagihara, B., 1974, The outline of mitochomdria, in: Mitochondria (B. Hagihara, ed.), pp. 1–104, Asakura Shoten, Tokyo.Google Scholar
  61. Hagihara, B., and Lardy, H. A., 1960, A method for the separation of orthophosphate from other phosphate compounds, J. Biol. Chem. 235:889.PubMedGoogle Scholar
  62. Hall, C., Wu, M., Crane, F. L., Takahashi, N., Tamura, S., and Folkers, K., 1966, Piericidin A: A new inhibitor of mitochondrial electron transport, Biochem. Biophys. Res. Commun. 25:373.PubMedGoogle Scholar
  63. Hansford, R. G., 1971, Some properties of mitochondria isolated from the flight muscle of periodical cicada, Magicicada septendecim, Biochem. J. 121:771. Hansford, R. G., and Chappell, J. B., 1967, The effect of Ca2+ on the oxidation of glycerol phosphate by blowfly mitochondria, Biochem. Biophys. Res. Commun. 27:686.Google Scholar
  64. Hansford, R. G., and Sacktor, B., 1970, The control of the oxidation of proline by isolated flight muscle mitochondria, J. Biol. Chem. 245:991.PubMedGoogle Scholar
  65. Harano, T., and Chino, H., 1971, A new diaphorase from Bombyx silkworm eggs—Cytochrome c reductase activity mediated with xanthommatin, Arch. Biochem. Biochem. Biophys. 146:467.Google Scholar
  66. Harvey, W. R., and Haskeil, J. A., 1966, Metabolic control mechanisms in insect, Advan. Insect Physiol. 3:133.Google Scholar
  67. Hollunger, G., 1955, Guanidines and oxidative phosphorylations, Acta pharmacol. Toxicol. 11: Suppl. No. 1,84 pp.Google Scholar
  68. Horgan, D. J., Singer, T. P., and Casida, J. E., 1968a, Studies on the respiratory chain-linked reduced nicotine-amide adenine dinucleotide dehydrogenase. XII. Binding sites of rotenone, piericidin A, and amytal in the respiratory chain, J. Biol. Chem. 243:834.PubMedGoogle Scholar
  69. Horgan, D. J., Ohno, H., Singer, T. P., and Casida, J. E., 1968b, Studies on the respiratory chain-linked reduced nicotine-amide adenine dinucleotide dehydrogenase. IV. Interactions of piericidin with the mitochondrial respiratory chain, J. Biol. Chem. 243:5967.PubMedGoogle Scholar
  70. Hosotsuji, T., 1956, Japanese Patent S 36-147.Google Scholar
  71. Hülsmann, W. C., Elliott, W. B., and Slater, E. C., 1960, The nature and mechanism of action uncoupling agents present in mitochrome preparations, Biochim. Biophys. Acta 39:267.PubMedGoogle Scholar
  72. Ilivicky, J., and Casida, J. E., 1969, Uncoupling action of 2,4-dinitrophenols, 2-trifluoromethylbenzimidazoles and certain other pesticide chemicals upon mitochondria from different sources and its relation to toxicity, Biochem. Pharmacol. 18:1389.PubMedGoogle Scholar
  73. Ilivicky, J., Chefurka, W., and Casida, J. E., 1967, Oxidative phosphorylation and sensitivity to uncouplers of housefly mitochondria: Influence of isolation medium, J. Econ. Entomol. 60:1404.PubMedGoogle Scholar
  74. Jeng, M., Hals, C., Crane, F. L., Takahashi, S., Tamura, S., and Folkers, K., 1968, Inhibition of mitochondrial electron transport by piericidin A and related compounds, Biochemistry 7:1311.PubMedGoogle Scholar
  75. Kallapur, V. L., and George, C. J., 1973, Fatty acid oxidation by the flight muscle of the dragonfly, Pantala flavescens, J. Insect Physiol. 19:1035.Google Scholar
  76. Keilin, D., and King, T. E., 1960, Effect of inhibitors on the activity of soluble succinic dehydrogenase and on the reconstitution of the succinic dehydrogenase cytochrome system from its components, Proc. Roy. Soc. 152B:163.Google Scholar
  77. Klingenberg, M., and Bücher, T., 1959, Flugmuskelmitochondrien aus Locusta migratoria mit Atmungskontrolle, Biochem. Z. 331:312.Google Scholar
  78. Klingenberg, M., Slenczka, W., and Ritt, E., 1959, Vergleichende Biochemie der Pyridinucleotid-System in Mitochondria Verschiedener Organe, Biochem. Z. 332:47.PubMedGoogle Scholar
  79. Kröger, A., and Klingenberg, M., 1966, On the role of ubiquinone in mitochondria. II. Redox reaction of ubiquinone under the control of oxidative phosphorylation, Biochem. Z. 344:317. Kubišta, V., 1957, Inorganic phosphate and the rate of glycolysis in insect muscle, Nature (London) 180:549.Google Scholar
  80. Kubišta, V., 1958, Anaerobic Glykolyse in den Insectenmuskeln, Biochem. Z. 330:315.PubMedGoogle Scholar
  81. Kurland, C. G., and Schneiderman, H. A., 1959, The respiratory enzymes or diapausing silkworm pupae: A new interpretation of carbon monoxide-insensitive respiration, Biol. Bull. 116:136.Google Scholar
  82. Lardy, H., and Ferguson, S. M., 1969, Oxidative phosphorylation in mitochondria, Ann. Rev. Biochem. 38:991.PubMedGoogle Scholar
  83. Lardy, H. A., and Wellman, H., 1952, Oxidative phosphorylation: Role of inorganic phosphate and acceptor systems in control of metabolic rates, J. Biol. Chem. 195:215.PubMedGoogle Scholar
  84. Lardy, H. A., Johnson, D., and McMurray, W. C., 1958, Antibiotics as tools for metabolic studies. I. Survey of toxic antibiotics in respiratory, Phosphorylative and glycolytic systems, Arch. Biochem. Biophys. 78:587.PubMedGoogle Scholar
  85. Lehninger, A. L., 1970, Biochemistry, Worth Publishers, New York.Google Scholar
  86. Lehninger, A. L., and Remmert, L. F., 1959, An endogenous uncoupling and swelling agent in liver mitochondria and its enzymic formation, J. Biol. Chem. 234:2459.PubMedGoogle Scholar
  87. Lester, R. L., and Crane, F. L., 1959, The natural occurrence of coensyme Q and related compounds, J. Biol. Chem. 234:2169.PubMedGoogle Scholar
  88. Lewis, S. E., and Slater, E. C., 1954, Oxidative phosphorylation in insect sarcomes, Biochem. J. 58:207.PubMedGoogle Scholar
  89. Lilian, M. E., and Ilse, D., 1970, An inhibitor of mitochondrial respiration in venom of the australian bull dog ant, Myrecia gulosa, J. Insect Physiol. 16:1531.Google Scholar
  90. Lindahl, P. E., and Öberg, K. E., 1961, The effect of rotenone on respiration and its point of attack, Exp. Cell. Res. 23:228.PubMedGoogle Scholar
  91. Marquardt, R. R., and Brosemer, R. W., 1966, Insect extramitochondrial glycerophosphate dehydrogenase. I. Crystallization and physical properties of the enzyme from honeybee (Apis mellifera) thoraces, Biochim. Biophys. Acta 128:454.Google Scholar
  92. Martius, C., and Märki, F., 1957, Ueber, Phyllochinon-Reductase, Biochem. Z. 329:450.Google Scholar
  93. Matsuda, M., and Fukami, J., 1972, Preliminary survey of effects of phenols on the oxidative phosphorylation in the American cockroach muscle mitochondria, Appl. Entomol. Zool. 7:27.Google Scholar
  94. McAllen, J. W., and Brown, A. W. A., 1960, The effect of insecticides on transamination in the American cockroach, J. Econ. Entomol. 53:166.Google Scholar
  95. Mitsui, T., Fukami, J., Fukunaga, K., Sagawa, T., Takahashi, N., and Tamure, S., 1969, Studies on piericidin. I. Effect of piericidin A and B on mitochondrial electron transport in insect, Botyu-Kagaku 34:126.Google Scholar
  96. Mitsui, T., Fukami, J., Fukunaga, K., Takahashi, N., and Tamura, S., 1970, Studies on piericidin: Antagonistic effect of vitamin K3 on the respiratory chain of insects and mammals in the presence of piericidin A, Agr. Biol. Chem. 34:1101.Google Scholar
  97. Muraoka, S., and Terada, H., 1972, 3,5-Di-terf-butyl-4-hydroxybenzylidene-malononitrile: New powerful uncoupler of respiratory-chain phosphorylation, Biochim. Biophys. Acta 275:271.PubMedGoogle Scholar
  98. O’Brien, R. D., 1956, The inhibition of cholinesterase and succinoxidase by malathion and its isomer, J. Econ. Entomol. 49:484.Google Scholar
  99. O’Brien, R. D., 1957, The effect of malathion and its isomer on carbohydrate metabolism of the mouse, cockroach and housefly, J. Econ. Entomol. 50:79.Google Scholar
  100. O’Brien, R. D., 1967, Insecticides: Action and Metabolism, Academic Press, New York.Google Scholar
  101. Obrien, R. D., Cheng, L., and Kimmel, E. C., 1965, Inhibition of the α-glycerophosphate shuttle in housefly flight muscle, J. Insect Physiol. 11:1241.Google Scholar
  102. Ohkawa, H., Ohkawa, R., Yamamoto, I., and Casida, J. E., 1972, Enzyme mechanisms and toxicological significance of hydrogen cyanide liberation from various organothiocyanates and organonitriles in mice and houseflies, Pestic. Biochem. Physiol. 2:95.Google Scholar
  103. Ohnishi, K., 1966, Studies on cytochrome b. III. Comparison of cytochrome B’s from beef heart muscle and larvae of the housefly, J. Biochem. 59:17.PubMedGoogle Scholar
  104. Okada, Y., 1973, The Studies of Cytochrome, pp. 165–176, University of Tokyo Press, Tokyo.Google Scholar
  105. Orser, W. B., and Brown, A. W. A., 1951, The effect of insecticides on the heart beat of Periplaneta, Can. J. Zool. 29:54.Google Scholar
  106. Osanai, M., 1966, The pigment of silkworm’s egg, Jpn. Zool. Mag. 71:381.Google Scholar
  107. Parker, V. H., 1958, Effect of nitrophenols and halogenophenols on the enzymic activity of rat-liver mitochondria, Biochem. J. 69:306.PubMedGoogle Scholar
  108. Piper, G. R., and Casida, J. E., 1965, Housefly adenosine triphosphatases and their inhibition by insecticidal organotin compounds, J. Econ. Entomol. 58:392.Google Scholar
  109. Pressman, B. C., and Lardy, H. A., 1956, Effect of surface active agents on the latent ATPase of mitochondria, Biochim. Biophys. Acta 21:458.PubMedGoogle Scholar
  110. Pullman, M. E., and Racker, E., 1956, Spectrophotometric studies of oxidative phosphorylation, Science 123:1105.PubMedGoogle Scholar
  111. Quagliariello, E., Palmieri, F., Alifano, A., and Papa, S., 1966, 3-Hydroxyanthranilic acidmediated respiration in the inhibited respiratory chain, Biochim. Biophys. Acta 113:482.PubMedGoogle Scholar
  112. Rees, K. B., 1954, Aerobic metabolism of the muscle of Locusta migratoria, Biochem. J. 58:196.PubMedGoogle Scholar
  113. Remmert, L. F., and Lehninger, A. L., 1959, A mitochondrial factor producing “loose-coupling” of respiration, Proc. Natl. Acad. Sci. U.S.A. 45:1.PubMedGoogle Scholar
  114. Rose, M. S., and Lock, E. A., 1970, The interaction of triethyltin with a component of guinea-pig liver supernatant: Evidence for histidine in the binding sites, Biochem. J. 120:151.PubMedGoogle Scholar
  115. Sacklin, J. A., Terriere, L. C., and Remmert, L. F., 1955, Effect of DDT on enzymatic oxidation and phosphorylation, Science 122:377.PubMedGoogle Scholar
  116. Sacktor, B., 1953, Investigations on the mitochondria of the housefly, Musca domestica L., J. Gen. Physiol. 36:371.PubMedGoogle Scholar
  117. Sacktor, B., 1954, Investigations on the mitochondria of housefly, Musca domestica L. III. Requirements for oxidative phosphorylation. J. Gen. Physiol. 37:343.Google Scholar
  118. Sacktor, B., 1961, The role of mitochondria in respiratory metabolism of flight muscle, Ann. Rev. Entomol. 6:103.Google Scholar
  119. Sacktor, B., 1965, Energetics and metabolism of muscular contraction, in: Physiology of Insecta, Vol. II (M. Rockstein, ed.), pp. 484–580, Academic Press, New York.Google Scholar
  120. Sacktor, B., 1974, Biological oxidations and energetics in insect mitochondria, in: Physiology of Inseda, Vol. IV (M. Rockstein, ed.), pp. 271–353, Academic Press, New York.Google Scholar
  121. Sacktor, B., and Childress, C. C., 1967, Metabolism of proline in insect flight muscles and its significance in stimulating the oxidation of pyruvate, Arch. Biochem. Biophys. 120:583.Google Scholar
  122. Sacktor, B., and Cochran, D. G., 1958, The respiratory metabolism of insect flight muscle. I. Manometric studies of oxidation and concomitant phosphorylation with sarcosomes, Arch. Biochem. Biophys. 74:266.PubMedGoogle Scholar
  123. Sacktor, B., and Wormser-Shavit, E., 1966, Regulation of metabolism in working muscle in vivo. I. Concentrations of some glycolytic, tricarboxylic acid cycle, and amino acid intermediates in insect flight muscle during flight, J. Biol. Chem. 241:624.PubMedGoogle Scholar
  124. Sacktor, B., O’Neil, J. J., and Cochran, D. G., 1958, The requirement of serum albumin in oxidative phosphorylation of flight muscle mitochondria, J. Biol. Chem. 233:1233.PubMedGoogle Scholar
  125. Slater, E. C., 1960, in: The Structure and Function of Muscle, Vol. 2 (G. Bourne, ed.), p. 105, Academic Press, New York.Google Scholar
  126. Takahashi, N., Suzuki, A., Kimura, Y., Miyamoto, S., Tamura, S., Mitsui, T., and Fukami, J., 1968, Isolation, structure and physiological activities of piericidin B: Natural insecticide produced by a streptomyces, Agr. Biol. Chem. 32:1115.Google Scholar
  127. Tamura, S., Takahashi, N., Miyamoto, S., Mori, R., Suzuki, S., and Nagatsu, J., 1963, Isolation and physiological activities of piericidin A, a natural insecticide produced by streptomyces, Agr. Biol. Chem. 27:576.Google Scholar
  128. Tischler, N., 1936, Studies on how derris kills insects, J. Econ. Entomol. 28:215.Google Scholar
  129. Tomizawa, C., and Fukami, J., 1956, Biochemical studies on the action of insecticides. II. The oxidative phosphorylation in the flight muscle of Locusta migratoria and the influences of insecticides, Oyo-Kontyu 12:1.Google Scholar
  130. Van den Bergh, S. G., 1964, Pyruvate oxidation and the permeability of housefly sarcosomes, Biochem. J. 93:128.PubMedGoogle Scholar
  131. Van den Bergh, S. G., 1967, Insect mitochondria, in: Methods in Enzymology, Vol. 10 (R. E. Estabrook and M. F. Pullman, eds.), p. 117, Academic Press, New York.Google Scholar
  132. Van den Bergh, S. G., and Slater, E. C., 1960, The respiratory activity and respiratory control of sarcosomes isolated from the thoracic muscle of the housefly, Biochim. Biophys. Acta 40:176.PubMedGoogle Scholar
  133. Van den Bergh, S. G., and Slater, E. C., 1962, The respiratory activity and permeability of housefly sarcosomes, Biochem. J. 82:362.PubMedGoogle Scholar
  134. Weinbach, E. C., 1954, The effect of pentachlorophenol on oxidative phosphorylation, J. Biol. Chem. 210:545.PubMedGoogle Scholar
  135. Weinbach, E. C., Sheffield, H., and Garbers, J., 1963, Restoration of oxidative and morphological integrity to swollen, and uncoupled rat mitochondria, Proc. Natl. Acad. Sci. U.S.A. 49:561.Google Scholar
  136. Weis-Fogh, T., 1964, Biology and physics of locust flight. VIII. Lift and metabolic rate of flying insects, J. Exp. Biol. 41:257.PubMedGoogle Scholar
  137. Whitehouse, H. W., 1964, Biochem. Pharmocol. 13:319.Google Scholar
  138. Williamson, R. L., and Metcalf, R. L., 1967, Salicylanilides: A new group of active uncouplers of oxidative phosphorylation, Science 158:1694.PubMedGoogle Scholar
  139. Winteringham, F. P. W., Hellyer, G. C., and McKay, M. A., 1960, Effects of the insecticides DDT and dieldrin on phosphorus metabolism of the adult housefly Musca domestica, Biochem. J. 76:543.PubMedGoogle Scholar
  140. Wojtczak, L., and Wojtczak, A. B., 1959, The action of serum albumin on oxidative phosphorylation in insect mitochondria, Biochim. Biophys. Acta 31:297.PubMedGoogle Scholar
  141. Yammasaki, T., and Narahashi, T., 1957, Effects of oxygen lack, metabolic inhibitors, and DDT on the resting potential of insect nerve. Studies on the mechanism of action of insecticides. XII, Botyu-Kagaku 22:259.Google Scholar
  142. Yust, H. R., and Shelden, F. F., 1952, A study of the physiology of resistance to hydrocyanic acid in the California red scale, Ann. Entomol. Soc. Am. 45:220.Google Scholar
  143. Zahavi, M., and Tahori, A. S., 1972, Activity of mitochondrial NAD-linked isocitric dehydrogen-ase in alatiform and apteriform larve of Myzus persicae, J. Insect Physiol. 18:608.Google Scholar
  144. Zebe, E. C., and McShan, W. H., 1957, Lactic and α-glycerophosphate dehydrogenase in insect, J. Gen. Physiol. 40:779.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1976

Authors and Affiliations

  • Jun-ichi Fukami
    • 1
  1. 1.Laboratory of Insect ToxicologyThe Institute of Physical and Chemical ResearchWako, SaitamaJapan

Personalised recommendations