Abstract
The classical period of pharmacogenetics is drawing to an end. Much of the work reviewed in this book has asked the question, “Are there genetic differences in actions of drug X?” The answer has always been “Yes.” We feel that it is now time to stop repeating these sorts of experiments and use the amply identified genetic differences to elucidate mechanisms of drug action. How can this be done? There are no cases so far where the complete path from behavioral response to the genome has been traced, so we can only speculate on what will be the most fruitful approaches. Much progress has been made linking molecular and classical genetics of drug metabolism, and neurophar-macologists can learn from these studies (Edenburg, Chapter 5; Meyer, 1990).
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© 1991 Springer Science+Business Media New York
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Harris, R.A., Crabbe, J.C. (1991). Overview. In: Crabbe, J.C., Harris, R.A. (eds) The Genetic Basis of Alcohol and Drug Actions. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2067-6_11
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DOI: https://doi.org/10.1007/978-1-4899-2067-6_11
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