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Neurochemical and Electrophysiological Events Underlying Stress-Induced Depression in an Animal Model

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Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 245)

Abstract

Exposing rats to uncontrollable shock produces behavioral and vegetative changes which bear considerable similarity to what is seen in human depression. This particular procedure represents the most widely-studied animal model of psychopathology. As a result of these studies, similarity of this model to human depression has been shown with respect to etiology, symptomatology, and responsiveness to treatment. These similarities will now be reviewed briefly.

Keywords

Locus Coeruleus Inescapable Shock Locus Coeruleus Neuron Neurochemical Basis Excitatory Stimulus 
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© Springer Science+Business Media New York 1988

Authors and Affiliations

  1. 1.Department of PsychiatryDuke University Medical CenterDurhamUSA

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