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Behavioral Pharmacology of Stress: Focus on CNS Corticotropin-Releasing Factor

  • George F. Koob
  • Karen Thatcher-Briton
  • Abdelouahhab Tazi
  • Michel Le Moal
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 245)

Abstract

Stress is a hypothetical construct which has been extensively studied for the past three decades at different levels of analysis. It is a ubiquitous concept in physiology, psychology and medicine that often eludes precise definition. Hans Selye conceptualized stress as “a nonspecific response to any demand upon the body (usually, but not always, noxious), or anything which causes an alteration of homeostatic processes (1)”. A more modern version of this definition, taken from Burchfield (2) has emphasized the concept of psychological homeostasis or the maintenance of a normal mood state at rest. All emotions then are changes from this state. Indeed, as Dr. John Mason showed so elegantly, without emotional changes accompanying a stressor, the stress response is minimal (3). Thus commonly accepted physiological “stressors” (heat, excercise, hunger) do not elicit a “stress response” when they are presented in a way that eliminates their psychological (emotional) effects (fear, conflict, uncertainty, frustration).

Keywords

Corticotropin Release Factor Acoustic Startle Shock Intensity Conflict Test Corticotropin Release Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • George F. Koob
    • 1
  • Karen Thatcher-Briton
    • 2
  • Abdelouahhab Tazi
    • 3
  • Michel Le Moal
    • 3
  1. 1.Dept of Basic and Clinical ResearchScripps Clinic and Research FoundationLa JollaUSA
  2. 2.Psychobiologie des Comportements AdaptatifsINSERM Unite-254France
  3. 3.Dept of Psychiatry, San Diego VeteransAdministration Medical Center & UCSD, Sch. of Med.La JollaUSA

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