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Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants pp 17–30Cite as

Current Research on Hemoglobin Adducts and Cancer Risks: An Overview

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Part of the book series: NATO ASI Series ((NSSA,volume 250))

Abstract

Most known chemical carcinogens are electrophilically reactive compounds (RX) or are formed in vivo from non-reactive precursors (A) (Miller and Miller, 1966). The electrophiles react with nucleophilic atoms (Y) of biomacromolecules giving rise to adducts (RY):

$$A \to RX\xrightarrow[{({k_y})}]{{ + {Y^ - }}}RY + {X^ - }$$
((1))

The measurement of adducts to sufficiently stable macromolecules may be used for identification of electrophiles in vivo and for dose monitoring as a basis for risk estimation. For reasons to be discussed below, the Stockholm group has used hemoglobin (Hb) for in vivo dose monitoring of chemical carcinogens in animals and humans.

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  1. Department of Radiobiology, Stockholm University, S-106 91, Stockholm, Sweden

    Margareta Törnqvist

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  1. Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    Curtis C. Travis

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Törnqvist, M. (1993). Current Research on Hemoglobin Adducts and Cancer Risks: An Overview. In: Travis, C.C. (eds) Use of Biomarkers in Assessing Health and Environmental Impacts of Chemical Pollutants. NATO ASI Series, vol 250. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-2052-2_3

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