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Neurobiological Research Priorities in Autism

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Neurobiological Issues in Autism

Part of the book series: Current Issues in Autism ((CIAM))

Abstract

Views regarding the etiology of infantile autism have shifted from early psychogenic hypotheses to today’s neurobiologic hypotheses as a result of scientific research. Both careful biological and careful behavioral studies have contributed to this dramatic shift. Behavioral studies have shown that cognitive deficits in autism are present in infancy, are primary rather than secondary to social withdrawal, are strongly prognostic, and place children at greater risk for seizures (Rutter, 1983). Biological studies of autism have identified a high incidence of minor physical anomalies, dermatoglyphic abnormalities, perinatal complications, and seizures, as well as subtle anatomical abnormalities on CT scans and associations with established medical disease (e.g., phenylketonuria, rubella) (DeMyer, Hingtgen, & Jackson, 1981). Yet no specific biological markers have been identified, and our knowledge of autism’s neurobiology remains quite limited.

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Authors and Affiliations

  1. Child Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, 20892, USA

    Judith M. Rumsey

  2. Developmental Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland, 20205, USA

    Martha B. Denckla

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  1. University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    Eric Schopler  & Gary B. Mesibov  & 

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Rumsey, J.M., Denckla, M.B. (1987). Neurobiological Research Priorities in Autism. In: Schopler, E., Mesibov, G.B. (eds) Neurobiological Issues in Autism. Current Issues in Autism. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1992-2_3

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  • DOI: https://doi.org/10.1007/978-1-4899-1992-2_3

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