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Biological Activity of Non-GnRH Synthetic Peptide Sequences of the GnRH Precursor

  • R. P. Millar
  • P. J. Wormald
  • M. J. Abrahamson
  • R. C. deL. Milton
  • K. Waligora

Abstract

The demonstration of GnRH biosynthesis by tryptic and carboxypeptidase B cleavage of a higher molecular precursor in sheep, pig and rat hypothalamus, and the postulate that pGlu1 is derived from cyclizafion of Gln while the amide of Gly10 is generated from an additional Gly followed by a pair of basic amino acid residues (Millar et al., 1977, 1978, 1981), was recently definitively demonstrated by nucleotide sequencing of human placental cDNA (Seeburg and Adelman, 1984) and human and rat hypothalamic cDNA (Adelman et al., 1986).

Keywords

Pituitary Cell Prolactin Secretion GnRH Receptor Gonadotropin Release GnRH mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • R. P. Millar
    • 1
  • P. J. Wormald
    • 1
  • M. J. Abrahamson
    • 1
  • R. C. deL. Milton
    • 1
  • K. Waligora
    • 1
  1. 1.MRC Regulatory Peptides Research Unit Department of Chemical Pathology, and Endocrine Laboratory, Department of MedicineUniversity of Cape Town Medical School and Groote Schuur HospitalObservatorySouth Africa

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