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Physiological and Biochemical Dissection of Mechanisms Underlying Puberty

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Book cover Endocrinology and Physiology of Reproduction

Abstract

The last few years have witnessed the emergence of a more comprehensive understanding of the mechanisms underlying the onset of mammalian puberty. At present, several groups utilizing different animal models are actively engaged in studying various aspects of the pubertal process, more noticeably the luteinizing hormone-releasing hormone (LHRH)-gonadotropin component of the reproductive axis.

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References

  • Adashi, E. Y., and Hsueh, A. J. W., 1981, Stimulation of β2-adrenergic responsiveness by follicle-stimulating hormone in rat granulosa cells in vitro and in vivo, Endocrinology, 108:2170.

    Article  PubMed  CAS  Google Scholar 

  • Advis, J. P., and Ojeda, S. R., 1978, Hyperprolactinemia induced precocious puberty in the female rat: ovarian site of actions, Endocrinology, 103:924.

    Article  PubMed  CAS  Google Scholar 

  • Advis, J. P., Smith-White, S. S., and Ojeda, S. R., 1981, Delayed puberty induced by chronic suppression of prolactin release in the female rat, Endocrinology, 109:1321.

    Article  PubMed  CAS  Google Scholar 

  • Advis, J. P., Smith-White, S. S., and Ojeda, S. R., 1981a, Activation of GH short loop negative feedback delays puberty in the female rat, Endocrinology, 108:1343.

    Article  PubMed  CAS  Google Scholar 

  • Aguado, L. I., and Ojeda, S. R., 1984, Prepubertal ovarian function is finely regulated by direct adrenergic influences. Role of the adrenergic innervation, Endocrinology, 114:1845.

    Article  PubMed  CAS  Google Scholar 

  • Aguado, L. I., and Ojeda, S. R., 1984a, Ovarian adrenergic nerves play a role in maintaining preovulatory steroid production, Endocrinology, 114:1944.

    Article  PubMed  CAS  Google Scholar 

  • Aguado, L. I., and Ojeda, S. R., 1984b, Effect of selective removal of the adrenal medulla on female sexual development, Biol. Reprod., 31:605.

    Article  PubMed  CAS  Google Scholar 

  • Ahmed, C. E., Dees, W. L., and Ojeda, S. R., 1986, The immature rat ovary is innervated by vasoactive intestinal peptide (VIP)-containing fibers and responds to VIP with steroid secretion, Endocrinology, 118:1682.

    Article  PubMed  CAS  Google Scholar 

  • Andrews, W. W., and Ojeda, S. R., 1977, On the feedback actions of estrogen on gonadotropins and prolactin release in infantile female rats, Endocrinology, 101:1517.

    Article  PubMed  CAS  Google Scholar 

  • Andrews, W. W., and Ojeda, S. R., 1981, A quantitative analysis of the maturation of steroid negative feedbacks controlling gonadotropin release in the female rat: transition from an androgenic to a predominantly estro-genic control, Endocrinology, 108:1313.

    Article  PubMed  CAS  Google Scholar 

  • Andrews, W. W., and Ojeda, S. R., 1981a, A detailed analysis of the serum LH secretory profiles of conscious, free-moving female rats during the time of puberty, Endocrinology, 109:2032.

    Article  PubMed  CAS  Google Scholar 

  • Andrews, W. W., Advis, J. P., and Ojeda, S. R, 1981, The maturation of estradiol negative feedback in fmeale rats: evidence that the resetting of the hypothalamic “gonadostat” does not precede the first preovulatory surge of gonadotropins, Endocrinology, 109:2022.

    Article  PubMed  CAS  Google Scholar 

  • Andrews, W. W., Mizejewski, G. J., and Ojeda, S. R., 1981a, Development of estradiol positive feedback on LH release in the female rat: a quantitative study, Endocrinology, 109:1404.

    Article  PubMed  CAS  Google Scholar 

  • Bond, J. F., Robinson, G. S., and Farmer, S. R., 1984, Differential expression of two neural cell-specific β-tubulin mRNAs during rat brain development, Mol. Cell. Biol., 4:1313.

    PubMed  CAS  Google Scholar 

  • Burden, H. W., 1985, The adrenergic innervation of mammalian ovaries, in: “Catecholamines as Hormone Regulators,” N. Ben-Jonathan, J. M. Bahr, and R. I. Weiner, eds., p. 261, Raven Press, New York.

    Google Scholar 

  • Caligaris, L., Astrada, J. J., and Taleisnik, S., 1972, Influence of age on the release of luteinizing hormone induced by estrogen and progesterone in immature rats, J. Endocrinol., 55:97.

    Article  PubMed  CAS  Google Scholar 

  • Clough, R. W., and Rodriguez-Sierra, J. F., 1983, Synaptic changes in the hypothalamus of the prepubertal female rat administered estrogen, Am. J. Anat., 167:205.

    Article  PubMed  CAS  Google Scholar 

  • Davoren, J. B., and Hsueh, A. J. W., 1984, Vasoactive intestinal peptide: a novel stimulator of steroidogenesis by cultured rat granulosa cells, Biol. Reprod., 33:37.

    Article  Google Scholar 

  • Davoren, J. B., and Hsueh, A. J. W., 1986, Growth hormone increases ovarian levels of immunoreactive somatomedin C/insulin-like growth factor I in vivo, Endocrinology, 118:888.

    Article  PubMed  CAS  Google Scholar 

  • Dees, W. L., Kozlowski, G. P., Dey, R., and Ojeda, S. R., 1985, Evidence for the existence of substance P in the prepubertal rat ovary. II. Immuno-cytochemical localization, Biol. Reprod., 33:471.

    Article  PubMed  CAS  Google Scholar 

  • Docke, F., Rohde, W., Gerber, P., and Dorner, G., 1984, Evidence that desensitization to the negative estrogen feedback is a prepubertal and not a postpubertal event in female rats, Exp. Clin. Endocrinol., 84:1.

    Article  PubMed  CAS  Google Scholar 

  • Eldridge, J. C., McPherson III, J. C., and Mahesh, V. D., 1977, Maturation of the negative feedback control of gonadotropin secretion in the female rat, Endocrinology, 94:1536.

    Article  Google Scholar 

  • Germain, B. L., Campbell, P. S., and Anderson, J. N., 1978, Role of the serum estrogen-binding protein in the control of tissue estradiol levels during postnatal development of the female rat, Endocrinology, 103:1401.

    Article  PubMed  CAS  Google Scholar 

  • Hage, A. J., Groen-Klevant, A. C., and Weischen, R., 1978, Follicle growth in the immature rat ovary, Acta Endocrinol. (Copenh.), 88:375.

    CAS  Google Scholar 

  • Jia, X-C., Kalmijn, J., and Hsueh, A. J. W., 1986, Growth hormone enhances follicle-stimulating hormone induced differentiation of cultured rat granulosa cells, Endocrinology, 118:1401.

    Article  PubMed  CAS  Google Scholar 

  • Kasson, B. G., Meidan, R., Davoren, J. B., and Hsueh, A. J. W., 1985, Identification of subpopulations of rat granulosa cells: sedimentation properties and hormonal responsiveness, Endocrinology, 117:1027.

    Article  PubMed  CAS  Google Scholar 

  • Kelch, R. P., Marshall, J. C., Saunder, S. E., Hopwood, N. J., and Reame, N. E., 1983, Gonadotropin regulation during human puberty, in: “Neuro-endocrine Aspects of Reproduction,” R. L. Norman, ed., p. 229, Academic Press, New York.

    Chapter  Google Scholar 

  • Kimura, F., and Kawakami, M., 1982, Episodic LH secretion in the immature male and female rat as assessed by sequential blood sampling, Neuro-endocrinology, 35:128.

    CAS  Google Scholar 

  • Kronibius, J., and Wuttke, W., 1977, Positive feedback action of estradiol on gonadotropin release in 15 day old rats, Acta Endocrinol., 86:263.

    Google Scholar 

  • Lawrence, I. E., and Burden, H. W., 1980, The origin of the extrinsic adre-nergic innervation to the rat ovary, Anat. Rec., 196:51.

    Article  PubMed  CAS  Google Scholar 

  • Ling, N. Ying, S-Y., Ueno, N., Shimasaki, S., Esch, F., Hotta, M., and Guillemin, R., 1986, Pituitary FSH is released by a hetero dimer of the β-subunits from the two forms of inhibin, Nature (Lond.), 321:779.

    Article  CAS  Google Scholar 

  • Matsumoto, A., and Arai, Y., 1976, Developmental changes in synaptic formation in the hypothalamic arcuate nucleus of female rats, Cell Tiss. Res., 169:143.

    CAS  Google Scholar 

  • Matsumoto, A. M., Karpas, A. E., Southworth, M. B., Dorsa, D. M., and Bremmer, W. J., 1986, Evidence for activation of the central nervous system-pituitary mechanism for gonadotropin secretion at the time of puberty in the male rat, Endocrinology, 119:362.

    Article  PubMed  CAS  Google Scholar 

  • McCormack, C. E., and Meyer, R. K., 1964, Minimal age for induction of ovulation with progesterone in rats: evidence for neural control, Endocrinology, 74:793.

    Article  PubMed  CAS  Google Scholar 

  • McDonald, J. K., Dees, W. L., Ahmed, C. E., Noe, B. D., and Ojeda, S. R., in preparation, Biochemical and immunocytochemical characterization of Neuropeptide Y in the immature rat ovary.

    Google Scholar 

  • Meijs-Roelofs, H. M. A., Uilenbroek, J. Th. J., de Greef, W. J., de Jong, F. H., and Kramer, P., 1975, Gonadotropin and steroid levels around the time of first ovulation in the rat, J. Endocrinol., 67:275.

    Article  PubMed  CAS  Google Scholar 

  • Meijs-Roelofs, H. M. A., and Kramer, P., 1979, Maturation of the inhibitory feedback action of estrogen on follicle-stimulating hormone secretion in the immature female rat: a role for alpha fetoprotein, J. Endocrinol., 81:199.

    Article  PubMed  CAS  Google Scholar 

  • Ojeda, S. R., and Campbell, W. B., 1982, An increase in hypothalamic capacity to synthesize PGE2 precedes the first preovulatory surge of gonadotro-pins, Endocrinology, 111:1031.

    Article  PubMed  CAS  Google Scholar 

  • Ojeda, S. R., and Aguado, L. I., 1985, Adrenergic control of the prepubertal ovary: involvement of local innervation and circulating catecholamines, in: “Catecholamines as Hormone Regulators,” N. Ben-Jonathan, J. M. Bahr, and R. I. Weiner, eds., p. 293, Raven Press, New York.

    Google Scholar 

  • Ojeda, S. R., Costa, M. E., Katz, K. H., and Hersh, L. B., 1985, Evidence for the existence of substance P in the prepubertal rat ovary. I. Biochemical and physiological studies, Biol. Reprod., 33:471.

    Article  PubMed  Google Scholar 

  • Ojeda, S. R., Smith (White), S. S., Urbanski, H. F., and Aguado, L. I., 1984, The onset of female puberty: underlying neuroendocrine mechanisms, in: “Neuroendocrine Perspectives,” vol. 3, p. 225, Elsevier, Amsterdam.

    Google Scholar 

  • Ojeda, S. R., Urbanski, H. F., and Ahmed, C. E., 1986, The onset of female puberty: studies in the rat, in: “Recent Progress in Hormone Research,” R. O. Greep, ed., vol. 42, p. 385, Academic Press, New York.

    Google Scholar 

  • Ojeda, S. R., Urbanski, H. F., Katz, K. H., and Costa, M. E., 1986a, Activation of estradiol-positive feedback at puberty: estradiol sensitizes the LHRH-releasing system at two different biochemical steps, Neuro-endocrinology, 43:259.

    CAS  Google Scholar 

  • Ojeda, S. R., Urbanski, H. F., Katz, K. H., Costa, M. E., and Conn, P. M., 1986b, Activation of two different but complementary biochemical pathways induces release of hypothalamic luteinizing hormone-releasing hormone, Proc. Natl. Acad. Sci., 83:4932.

    Article  PubMed  CAS  Google Scholar 

  • Ojeda, S. R., and Urbanski, H. R., in press, Puberty in the rat, in: “Physiology of Reproduction,” E. Knobil and J. D. Neill, eds, Raven Press, New York.

    Google Scholar 

  • Parker, C. R. Jr., and Mahesh, V. B., 1976, Hormonal events surrounding the natural onset of puberty in female rats, Biol. Reprod., 14:347.

    Article  PubMed  CAS  Google Scholar 

  • Plant, T. M., 1983, Ontogeny of gonadotropin secretion in the Rhesus macaque (Macaca mulatta), in: “Neuroendocrine Aspects of Reproduction,” R. L. Norman, ed., p. 133, Academic Press, New York.

    Chapter  Google Scholar 

  • Ramirez, V. D., and McCann, S. M., 1963, Comparison of the regulation of luteinizing hormone (LH) secretion in immature and adult rats, Endocrinology, 72:452.

    Article  PubMed  CAS  Google Scholar 

  • Ramirez, V. D., Feder, H. H., and Sawyer, C. H., 1984, The role of brain catecholamines in the regulation of LH secretion: a critical inquiry, in: “Frontiers in Neuroendocrinology,” L. Martini and W. F. Ganong, eds., vol, 8, p. 27, Raven Press, New York.

    Google Scholar 

  • Raum, W. J., and Swerdloff, R. S., 1986, The effect of hypothalamic cate-cholamine synthesis inhibition by α-methyltyrosine on gonadotropin secretion during sexual maturation in the male Wistar rat, Endocrinology, 119:168.

    Article  PubMed  CAS  Google Scholar 

  • Ruf, K. B., 1982, Synaptogenesis and Puberty, Front. Horm. Res., 10:65.

    CAS  Google Scholar 

  • Steele, R. E., and Weisz, J., 1974, Changes in sensitivity of the estradiol-LH feedback system with puberty in the female rat, Endocrinology, 95:513.

    Article  PubMed  CAS  Google Scholar 

  • Terasawa, E., Nass, T. E., Yeoman, R. R., Loose, M. D., and Schultz, N. J., 1983, Hypothalamic control of puberty in the female Rhesus macaque, in: “Neuroendocrine Aspects of Reproduction,” R. L. Norman, ed., p. 149, Academic Press, New York.

    Chapter  Google Scholar 

  • Terasawa, E., Bridson, W. E., Nass, T. E., Noonan, J. J., and Dierschke, D. J., 1986, Developmental changes in the luteinizing hormone secretory pattern in peripubertal female Rhesus monkeys: comparisons between gonadally intact and ovariectomzied animals, Endocrinology, 115:2233.

    Article  Google Scholar 

  • Trzeciak, W. H., Ahmed, C. E., Simpson, E., and Ojeda, S. R., in press, Vasoactive intestinal peptide induces the synthesis of the cholesterol side chain cleavage enzyme complex in cultured rat ovarian granulosa cells, Proc. Natl. Acad. Sci.

    Google Scholar 

  • Urbanski, H. F., and Ojeda, S. R., 1985, The juvenile-peripubertal transition period in the female rat: establishment of a diurnal pattern of pulsatile luteinizing hormone secretion, Endocrinology, 117:644.

    Article  PubMed  CAS  Google Scholar 

  • Urbanski, H. F., and Ojeda, S. R., 1985a, In vitro stimulation of prepubertal changes in pulsatile luteinizing hormone release enhances progesterone and estradiol 17β-secretion from immature rat ovaries, Endocrinology, 117:638.

    Article  PubMed  CAS  Google Scholar 

  • Urbanski, H. F., and Ojeda, S. R., 1986, Development of afternoon minisurges of LH secretion is ovarian-dependent, Endocrinology, 118:1187.

    Article  PubMed  CAS  Google Scholar 

  • Urbanski, H. F., and Ojeda, S. R., submitted, Gonadal-independent activation of enhanced afternoon luteinizing hormone release during pubertal development in the female rat.

    Google Scholar 

  • Vale, W., Rivier, J., Vaugham, J., McClintock, R., Corrigan, A, Woo, W., Carr, D., and Spiess, J., 1986, Purification and characterization of an FSH-releasing protein from porcine ovarian follicular fluid, Nature (Lond.), 321:776.

    Article  CAS  Google Scholar 

  • Wray, S., and Hoffman, G., 1986, Postnatal morphological changes in rat LHRH neurons correlated with sexual maturation, Neuroendocrinology, 43:93.

    Article  PubMed  CAS  Google Scholar 

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© 1987 Springer Science+Business Media New York

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Ojeda, S.R., Urbanski, H.F., Ahmed, C.E., Rogers, L., Gonzalez, D. (1987). Physiological and Biochemical Dissection of Mechanisms Underlying Puberty. In: Leung, P.C.K., Armstrong, D.T., Ruf, K.B., Moger, W.H., Friesen, H.G. (eds) Endocrinology and Physiology of Reproduction. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1971-7_10

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  • DOI: https://doi.org/10.1007/978-1-4899-1971-7_10

  • Publisher Name: Springer, Boston, MA

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