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Searches for Human H-Y by Conventional Means, and how it all began

  • E. J. Eichwald
  • C. R. Silmser
  • C. Jorgensen
  • J. Shelby
Chapter
Part of the Reproductive Biology book series (RBIO)

Abstract

It would appear that H-Y has two faces, not only in regard to its fields of action, but also in regard to its deportment. On the one hand H-Y is present, and makes itself persistently felt, throughout the vertebrate phylum, wherever there are heterogametes1; it is all-pervasive, and sees to it that a second gender arises; it sees to it that the genus, be it platyfish, rattlesnake, hippopotamus, or man does not attain a state of panfeminity. On the other hand, when it comes to immune responses, H-Y is fastidious, highly discriminating, and refuses to take action unless certain well-defined preconditions are met. We have learned from Hurme et al2, from Greene et al3, and from Liew et al4 that even a relatively simple event, e. g. delayed type hypersensitivity (DTH), or the rejection of murine skin grafts, will not come to pass unless responders carry the b allele of the MHC locus and, in addition the b allele of the I-B sublocus. In an equally simple event, namely, the elaboration of cytotoxic cells, the I-B sublocus matters less, and what is important is the I-A sublocus. It is surprising, then, that H-Y was first observed, not while it performed its pervasive sex-determining role, but when the demanding conditions for immune responsiveness were incidentally met5. I shall return briefly to this aspect below.

Keywords

Delay Type Hypersensi Histologic Response Popliteal Lymph Node Histologic Assay Male Skin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • E. J. Eichwald
    • 1
  • C. R. Silmser
    • 1
  • C. Jorgensen
    • 1
  • J. Shelby
    • 1
  1. 1.Department of PathologyUniversity of Utah Medical CenterSalt Lake CityUSA

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