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Skeletal Muscle Fatty Acid Transport and Transporters

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Book cover Skeletal Muscle Metabolism in Exercise and Diabetes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 441))

Abstract

Long-chain fatty acids (LCFAs) are an important energy source for many tissues. The dogma that LCFAs are freely diffusible has been challenged. It is now known that LCFAs are transported into many tissues. Our studies have shown that LCFAs are also transported into skeletal muscle and into the heart. In recent years a number of putative fatty acid transport proteins have been identified. These are known as plasma membrane fatty acid binding protein (FABPpm, 43 kDa), fatty acid translocase (FAT, 88 kDa) and fatty acid transporter protein (FATP, 63 kDa). All three proteins are present in skeletal muscle and in the heart. The existence of an LCFA transport system in muscle may be essential 1) to facilitate the rapid and regulatable transport of LCFA to meet the metabolic requirements of working muscles and 2) to cope with an increase in circulating LCFAs in some pathological conditions (e. g. diabetes). There is now some evidence that metabolic changes and chronically increased muscle activity can increase the transport of LCFAs and increase the expression of putative LCFA transporters.

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Authors and Affiliations

  1. Department of Kinesiology, University of Waterloo, Ontario, Canada, N2L 3G1

    A. Bonen & J. J. F. P. Luiken

  2. Department of Exercise and Sport Science, East Carolina University, Greenville, North Carolina, 27858-4353, USA

    D. J. Dyck

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  1. A. Bonen
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Editors and Affiliations

  1. Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark

    Erik A. Richter , Bente Kiens , Henrik Galbo  & Bengt Saltin , ,  & 

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Bonen, A., Dyck, D.J., Luiken, J.J.F.P. (1998). Skeletal Muscle Fatty Acid Transport and Transporters. In: Richter, E.A., Kiens, B., Galbo, H., Saltin, B. (eds) Skeletal Muscle Metabolism in Exercise and Diabetes. Advances in Experimental Medicine and Biology, vol 441. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1928-1_18

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