Abstract
The concept of molecular imprinting has been outlined in Chapter 23 of this volume. The preparation of molecular imprints in synthetic polymers is basically a three-step procedure (Fig. 1). The first step is the formation of specific and definable interactions between the monomer(s) and the print molecule. These interactions are subsequently responsible for the recognition of the print molecules by the imprinted polymer. The interactions can either be noncovalent bonds (Arshady and Mosbach, 1981, Ekberg and Mosbach, 1989), for example, ionic bonds and hydrogen bonds, or reversible covalent bonds, for example, boronic esters, (Wulff, 1986). In the first instance, the interactions are formed simply by mixing the print molecule with a suitable mixture of monomer(s) in an appropriate solvent prior to the polymerization. In the second instance, where covalent bonds are employed, an adduct composed of the print molecule and the monomer(s) is synthesized and is added to the polymerization mixture.
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Andersson, L.I., Ekberg, B., Mosbach, K. (1993). Bioseparation and Catalysis in Molecularly Imprinted Polymers. In: Ngo, T.T. (eds) Molecular Interactions in Bioseparations. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1872-7_24
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DOI: https://doi.org/10.1007/978-1-4899-1872-7_24
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