Abstract
Until recently, in vitro percutaneous absorption studies were conducted with non-viable skin. Early studies have shown that for many chemicals good in vivo-in vitro agreement can be obtained with nonviable skin (Bronaugh et al., 1982a). This is most likely due to the fact that the nonliving upper layer of skin, the stratum corneum, is a major barrier to absorption. However, no information was obtained in these studies about first-pass metabolism in skin.
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© 1996 Springer Science+Business Media New York
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Bronaugh, R.L. (1996). In Vitro Viable Skin Model. In: Borchardt, R.T., Smith, P.L., Wilson, G. (eds) Models for Assessing Drug Absorption and Metabolism. Pharmaceutical Biotechnology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1863-5_20
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DOI: https://doi.org/10.1007/978-1-4899-1863-5_20
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