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Use of an Isolated Perfused Kidney to Assess Renal Clearance of Drugs

Information Obtained in Steady-State and Non-Steady-State Experimental Systems
  • Noriko Okudaira
  • Yuichi Sugiyama
Part of the Pharmaceutical Biotechnology book series (PBIO, volume 8)

Abstract

The kidney plays an important role in eliminating foreign compounds that enter the body as well as in regulating the body pool of endogenous substances. The appearance of drug in the urine is the net result of glomerular filtration, tubular secretion and reabsorption (Fig. 1).

Keywords

Glomerular Filtration Rate Renal Clearance Mean Transit Time Tubular Secretion Urine Flow Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Noriko Okudaira
    • 1
  • Yuichi Sugiyama
    • 2
  1. 1.Pharmaceutical Research CenterMeiji Seika Kaisha, Ltd.Yokohama 222Japan
  2. 2.Faculty of Pharmaceutical SciencesUniversity of TokyoTokyo 113Japan

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