Use of an Isolated Perfused Kidney to Assess Renal Clearance of Drugs
The kidney plays an important role in eliminating foreign compounds that enter the body as well as in regulating the body pool of endogenous substances. The appearance of drug in the urine is the net result of glomerular filtration, tubular secretion and reabsorption (Fig. 1).
KeywordsGlomerular Filtration Rate Renal Clearance Mean Transit Time Tubular Secretion Urine Flow Rate
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