The Molecular Basis of Baculovirus Host Range
Because baculoviruses are currently important in a broad spectrum of biotechnologies ranging from biological pest control to gene expression vectors, an understanding of the molecular basis of the restriction of the replication of individual members of this virus family to a relatively small number of species is important. Understanding the nature of such host range restrictions will allow more accurate predictions regarding the potential effects of modifying the viral genomes and the impact of such modifications on the ability of the viruses to infect beneficial or nontarget organisms.
KeywordsHost Range Insect Cell Insect Cell Line Nuclear Polyhedrosis Virus Midgut Cell
Unable to display preview. Download preview PDF.
- Davidson, D. J., and Castellino, F. J., 1991, Asparagine-linked oligosaccharide processing in lepidopteran insect cells. Temporal dependence of the nature of the oligosaccharides assembled on asparagine-289 of recombinant human plasminogen produced in baculovirus vector infected Spodoptera frugiperda (IPLB-SF-21-AE) cells, Biochemistry 30:6167.CrossRefGoogle Scholar
- Entwistle, P. F., Adams, P. H. W., and Evans, H. F., 1978, Epizootiology of a nuclear polyhedrosis virus in European spruce sawfly (Gilpinia hercyniae): The rate of passage of infective virus through the gut of birds during cage tests, J. Invertebr. Pathol. 15:173.Google Scholar
- He, B., Chou, J., Liebermann, D. A., Hoffman, B., and Roizman, B., 1996, The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells, J. Virol. 70:84.PubMedGoogle Scholar
- Kamita, S. G., and Maeda, S., 1996a, Sequencing of the putative DNA helicase-encoding gene of Bombyx mori nuclear polyhedrosis virus and fine-mapping of a region involved in host range expansion, Gene (accepted).Google Scholar
- Lautenschlager, R. A., and Podgwaite, J. D., 1979, Passage rates of nucleopolyhedrosis virus by avian and mammalian predators of the gypsy moth, Environ. Entomol. 8:210.Google Scholar