Skip to main content

Baculovirus Pathogenesis

  • Chapter

Part of the The Viruses book series (VIRS)

Abstract

Humans have been aware of diseases caused by baculoviruses for over 2000 years. The earliest historical accounts originated with descriptions of silkworm “jaundice,” a disease of Bombyx mori that we now know is caused by a nuclear polyhedrosis virus. In addition, people in various cultures throughout history have witnessed, without knowing their cause, spectacular epizootics and subsequent population declines brought about by nuclear polyhedrosis and granulosis viruses in caterpillars and sawfly larvae that feed in the forests and on field and vegetable crops (Benz, 1986). However, it was not until this century, and especially since the end of World War II, that the etiologic agents that cause these diseases were identified as a unique family of viruses, now known as the baculoviruses, which are largely restricted to insects. Moreover, although the literature from the first half of this century contains good descriptions of the diseases caused by nuclear polyhedrosis and granulosis viruses, it is only recently that we have begun to understand the progression of these diseases in their hosts and to identify the genes and gene products that underlie their various pathologies.

Keywords

  • Basal Lamina
  • Nuclear Polyhedrosis Virus
  • Tissue Tropism
  • Midgut Epithelium
  • Occlusion Body

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-1-4899-1834-5_3
  • Chapter length: 27 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   169.00
Price excludes VAT (USA)
  • ISBN: 978-1-4899-1834-5
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD   219.99
Price excludes VAT (USA)
Hardcover Book
USD   299.99
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams, J. R., Goodwin, R. H., and Wilcox, T. A., 1977, Electron microscope investigations on invasion and replication of insect baculoviruses in vivo and in vitro. Biol. Cellulaire 28:261.

    Google Scholar 

  • Adang, M. J., and Spence, K. D., 1981, Surface morphology of peritrophic membrane formation in the cabbage looper, Trichoplusia ni, Cell Tiss. Res. 218:214.

    Google Scholar 

  • Adang, M. J., and Spence, K. D., 1983, Permeability of the peritrophic membrane of the Douglas fir tussock moth (Orgyia pseudotsugata), Comp. Biochem. Physiol. A 74:233.

    CrossRef  Google Scholar 

  • Aizawa, K., 1963, The nature of infections caused by nuclear-polyhedrosis viruses, in: Insect Pathology, An Advanced Treatise, Vol. 1 (E. A. Steinhaus, ed.), pp. 381–412, Academic Press, New York.

    Google Scholar 

  • Benz, G., 1963, A nuclear polyhedrosis of Malacosoma alpicola (Staudinger), J. Insect Pathol. 5:215.

    CAS  Google Scholar 

  • Benz, G. A., 1986, Introduction: Historical perspectives, in: The Biology of Baculoviruses, Vol. I, Biological Properties and Molecular Biology (R. R. Granados and B. A. Federici, eds.), pp. 1–35, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Bussard, G. W., and Rohrmann, G. F., 1989, Location, sequence, transcriptional mapping, and temporal expression of the gp64 envelope glycoprotein gene of the Orgyia pseudotsugata multinucleocapsid nuclear polyhedrosis virus, Virology 170:537.

    CrossRef  Google Scholar 

  • Blissard, G. W., and Rohrmann, G. F., 1990, Baculovirus diversity and molecular biology, Annu. Rev. Entomol. 35:127.

    PubMed  CrossRef  CAS  Google Scholar 

  • Blissard, G. W., and Wenz, J. R., 1992, Baculovirus gp64 envelope glycoprotein is sufficient to mediate pH-dependent membrane fusion, J. Virol. 66:6829.

    PubMed  CAS  Google Scholar 

  • Charlton, C. A., and Volkman, L. E., 1993, Baculoviruses, vertebrate viruses, and cytoskeletons, in: Parasites and Pathogens of Insects, Vol. 2. Pathogens (N. E. Beckage, S. N. Thompson, and B. A. Federici, eds.), pp. 103–125, Academic Press, San Diego.

    Google Scholar 

  • Couch, J. A., 1991, Baculoviridae. Part 2. Nuclear polyhedrosis viruses of invertebrates other than insects, in: Atlas of Invertebrate Viruses (J. R. Adams and J. R. Bonami, eds.), pp. 205–226, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Cunningham, J. C., and Entwistle, P. F., 1981, Control of sawflies by baculovirus, in: Microbial Control of Pests and Plant Diseases, 1970–1980 (H. D. Burges, ed.), pp. 379–407, Academic Press, London.

    Google Scholar 

  • Derksen, A. C. G., and Granados, R. R., 1988, Alteration of a lepidopteran peritrophic membrane by baculoviruses and enhancement of viral infectivity, Virology 167:241.

    CrossRef  Google Scholar 

  • Engelhard, E. K., Kam-Morgan, L. N. W., Washburn, J. O., and Volkman, L. E., 1994, The insect tracheal system: A conduit for the systemic spread of Autographa californica M nuclear polyhedrosis virus, Proc. Natl. Acad. Sci. USA 91:3224.

    PubMed  CrossRef  CAS  Google Scholar 

  • Federici, B. A., 1986, Ultrastructure of baculoviruses, in: The Biology of Baculoviruses, Vol. I, Biological Properties and Molecular Biology (R. R. Granados and B. A. Federici, eds.), pp. 61–88, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Federici, B. A., 1993, Viral pathobiology in relation to insect control, in: Parasites and Pathogens of Insects, Vol. 2, Pathogens (N. E. Beckage, S. N. Thompson, and B. A. Federici, eds.), pp. 81–101, Academic Press, San Diego.

    Google Scholar 

  • Federici, B. A., and Anthony, D. W., 1972, Formation of virion-occluding protenic spindles in a baculovirus disease of Aedes trisehatus, J. Invertebr. Pathol. 20:129.

    CrossRef  Google Scholar 

  • Federici, B. A., and Lowe, R. E., 1972, Studies on the pathology of a baculovirus in Aedes triseriatus, J. Invertebr. Pathol. 20:14.

    PubMed  CrossRef  CAS  Google Scholar 

  • Federici, B. A., and Stern, V. M., 1990, Replication and occlusion of a granulosis virus in larval and adult midgut epithelium of the western grapeleaf skeletonizer, Harrisina brillians, J. Invertebr. Pathol. 56:401

    CrossRef  Google Scholar 

  • Flipsen, J. T. M., van Lent, J. W. M., Goldbach, R. W., and Vlak, J. M., 1993, Expression of polyhedrin and p10 in the midgut of AcMNPV-infected Spodoptera exigua larvae: An immunoelectron microscope investigation, J. Invertebr. Pathol. 61:17.

    CrossRef  CAS  Google Scholar 

  • Flipsen, J. T. M., Martens, J. W. M., Van Oers, M. M., Vlak, J. M., and Van Lent, J. W. M., 1995, Passage of Autographa californica nuclear polyhedrosis virus through the midgut epithelium of Spodoptera exigua larvae, Virology 208:328.

    PubMed  CrossRef  CAS  Google Scholar 

  • Gijzen, M., Roelvink, P., and Granados, R. R., 1995, Characterization of a viral enhancing protein from Trichoplusia ni granulosis virus, J. Invertebr. Pathol. 65:289.

    CrossRef  Google Scholar 

  • Granados, R. R., 1978, Early events in the infection of Heliothis zea midgut cells by a baculovirus, Virology 90:170.

    PubMed  CrossRef  CAS  Google Scholar 

  • Granados, R. R., and Lawler, K. A., 1981, In vivo pathway of Autographa californica baculovirus invasion and infection, Virology 108:297.

    PubMed  CrossRef  CAS  Google Scholar 

  • Granados, R. R., and Williams, K. A., 1986, In vivo infection and replication of baculoviruses, in: The Biology of Baculoviruses, Vol. I, Biological Properties and Molecular Biology (R. R. Granados and B. A. Federici, eds.), pp. 89–108, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Hamm, J. J., 1968, Comparative histopathology of a granulosis and a nuclear polylhedrosis of Spodoptera frugiperda, J. Invertebr. Pathol. 10:320.

    PubMed  CrossRef  CAS  Google Scholar 

  • Harrap, K. A., 1970, Cell infection by a nuclear polyhedrosis virus, Virology 42:311.

    PubMed  CrossRef  CAS  Google Scholar 

  • Harrap, K. A., and Robertson, J. S., 1968, A possible infection pathway in the development of a nuclear polyhedrosis virus, J. Gen. Virol. 3:221.

    CrossRef  Google Scholar 

  • Hashimoto, Y., Corsaro, B. G., and Granados, R. R., 1991, Location and nucleotide sequence of the gene encoding the viral enhancing factor of the Trichoplusia ni granulosis virus, J. Gen. Virol. 72:2645.

    PubMed  CrossRef  CAS  Google Scholar 

  • Hawtin, R. E., Arnold, K., Ayres, M. D., de A. Zanotto, P. M., Howard, S. C., Gooday, G. W., Chappell, L. H., Kitts, P. A., King, L. A., and Possee, R. D., 1995, Identification and preliminary characterization of a chitinase gene in the Autographa californica nuclear polyhdrosis virus genome, Virology 212:673.

    PubMed  CrossRef  CAS  Google Scholar 

  • Horton, H. M., and Burand, J. P., 1993, Saturable attachment sites for polyhedron-derived baculovirus on insect cells and evidence for entry via direct membrane fusion, J. Virol. 67:1860.

    PubMed  CAS  Google Scholar 

  • Huger, A., 1963, Granuloses of insects, in: Insect Pathology, An Advanced Treatise, Vol. 1 (E. A. Steinhaus, ed.), pp. 531–575, Academic Press, New York.

    Google Scholar 

  • Jarvis, D. L., and Garcia, Jr., A., 1994, Biosynthesis and processing of the Autographa californica nuclear polyhedrosis virus gp64 protein, Virology 205:300.

    PubMed  CrossRef  CAS  Google Scholar 

  • Keddie, B. A., Aponte, G. W., and Volkman, L. E., 1989, The pathway of infection of Autographa californica nuclear polyhedrosis virus in an insect host, Science 243:1729.

    CrossRef  Google Scholar 

  • Kirkpatrick, B. A., Washburn, J. O., Engelhard, E. K., and Volkman, L. E., 1994, Primary infection of insect tracheae by Autographa californica M nuclear polyhedrosis virus, Virology 203:184.

    PubMed  CrossRef  CAS  Google Scholar 

  • Larsson, R., 1984, Insect pathological investigations on Swedish Thysanura: A nuclear polyhedrosis virus of the Bristletail Dilta hibernica, J. Invertebr. Pathol. 44:172.

    CrossRef  Google Scholar 

  • Lepore, L. S., Roelvink, P. R., and Granados, R. R., 1996, Enhancin, the granulosis virus protein that facilitates nucleopolyhedrosis (NPV) infections, is a metalloprotease, J. Invertebr. Pathol. 68:131.

    PubMed  CrossRef  CAS  Google Scholar 

  • Monsma, S. A., Oomens, A. G. P., and Blissard, G. W., 1996, The gp64 envelope fusion protein is an essential baculovirus protein required for cell-to-cell transmission and infection, J. Virol. 70:4607.

    PubMed  CAS  Google Scholar 

  • Knebel-Morsdorf, D., Flipsen, J. T. M., Roncarati, R., Jahnel, F., Kleefsmen, A. W. F., and Vlak, J. M., 1996, Baculovirus infection of Spodoptera exigua larvae: lacZ expression driven by promoters of early genes pe38 and me53 in larval tissue, J. Gen. Virol. 77:815.

    PubMed  CrossRef  Google Scholar 

  • O’Reilly, D. R., and Miller, L. K., 1989, A baculovirus blocks insect molting by producing ecdysteroid UDP-glucosyl transferase, Science 245:1110.

    PubMed  CrossRef  Google Scholar 

  • O’Reilly, D. R., and Miller, L. K., 1991, Improvement of a baculovirus pesticide by deletion of the EGT gene, Bio/technology 9:1086.

    CrossRef  Google Scholar 

  • Paillot, A., 1935, Nouvel ultravirus parasite d’Agrotis segetum provoquant une proliferation des tissues infectes, C R Hebd. Seances Acad. Sci. 201:1062.

    Google Scholar 

  • Reddy, J. T., and Locke, M., 1990, The size limited penetration of gold particles through insect basal laminae, J. Insect Physiol. 36:397.

    CrossRef  CAS  Google Scholar 

  • Rohrmann, G. F., 1986, Evolution of occluded baculoviruses, in: The Biology of Baculoviruses, Vol. I, Biological Properties and Molecular Biology (R. R. Granados and B. A. Federici, eds.), pp. 203–215, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Smith, K. A., 1955, Intranuclear changes in the polyhedrosis of Tipula paludosa (Diptera), Nature 176:255.

    PubMed  CrossRef  CAS  Google Scholar 

  • Smith, O. J., Hughes, K. M., Dunn, P. H., and Hall, I. M., 1956, A granulosis virus disease of the Western grapeleaf skeletonizer and its transmission, Can. Entomol. 88:507.

    CrossRef  Google Scholar 

  • Steinhaus, E. A., 1949, Principles of Insect Pathology, McGraw-Hill, New York.

    Google Scholar 

  • Steinhaus, E. A., and Hughes, K. M., 1952, A granulosis virus of the Western grapeleaf skeletonizer, J. Econ. Entomol. 24:744.

    Google Scholar 

  • Summers, M. D., 1969, Apparent in vivo pathway of granulosis virus invasion and infection, J. Virol. 4:188.

    PubMed  CAS  Google Scholar 

  • Summers, M. D., 1971, Electron microscopic observations on granulosis virus entry, uncoating, and replication process during infection of the midgut cells of Trichoplusia ni, J. Ultrastruct. Res. 35:606.

    PubMed  CrossRef  CAS  Google Scholar 

  • Tanada, Y., and Hess, R. T., 1991, Baculoviridae. Granulosis viruses, in: Atlas of Invertebrate Viruses (J. R. Adams and J. R. Bonami, eds.), pp. 227–257, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Tanada, Y, and Kaya, H. K., 1993, Insect Pathology, Academic Press, San Diego.

    Google Scholar 

  • Tanada, Y, and Leutenegger, R., 1968, Histopathology of a granulosis virus disease of the codling moth, Carpocapsa pomonella, J. Invertebr. Pathol. 10:39.

    CrossRef  CAS  Google Scholar 

  • Tweeten, K. A., Bulla, L. A., and Consigli, R. A., 1981, Applied and molecular aspects of insect granuloses viruses, Microbiol. Rev. 45:379.

    PubMed  CAS  Google Scholar 

  • van Oers, M. M., Flipsen, J. T. M., Reusken, C. B. E. M., Sliwinsky, E. L., Goldbach, R. W, and Vlak, J. M., 1993, Functional domains of the p10 protein of Autographa californica nuclear polyhedrosis virus, J. Gen. Virol. 74:563.

    PubMed  CrossRef  Google Scholar 

  • Volkman, L. E., and Knudson, D. L., 1986, In vitro replication of baculoviruses, in: The Biology of Baculoviruses, Vol. I, Biological Properties and Molecular Biology (R. R. Granados and B. A. Federici, eds.), pp. 109–120, CRC Press, Boca Raton, FL.

    Google Scholar 

  • Volkman, L. E., Blissard, G. W, Friesen, P., Keddie, B. A., Possee R., and Theilmann, D. A., 1995, Family Baculoviridae, in: Virus Taxonomy (F. A. Murphy, C. M. Fauquet, D. H. L. Bishop, S. A. Ghabrial, A. W. Jarvis, G. P. Martelli, M. A. Mayo, and M. D. Summers, eds.), pp. 104–113, Springer-Verlag, New York.

    Google Scholar 

  • Walker, S., Kawanishi, C. Y, and Hamm, J. J., 1982, Cellular pathology of a granulosis virus infection, J. Ultrastr. Res. 80:163.

    CrossRef  CAS  Google Scholar 

  • Wang, P., Hammer, D. A., and Granados, R. R., 1994, Interaction of Trichoplusia ni granulosis virus-encoded enhancin with the midgut epithelium and peritrophic membrane of four lepidopteran insects, J. Virol. 75:1961.

    CrossRef  CAS  Google Scholar 

  • Washburn, J. O., Kirkpatrick, B. A., and Volkman, L. E., 1995, Comparative pathogenesis of Autographa californica M nuclear polyhedrosis virus in larvae of Trichoplusia ni and Heliothis virescens, Virology 209:561.

    PubMed  CrossRef  CAS  Google Scholar 

  • Washburn, J. O., Kirkpatrick, B. A., and Volkman, L. E., 1996, Insect protection against viruses, Nature 383:767.

    CrossRef  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 1997 Springer Science+Business Media New York

About this chapter

Cite this chapter

Federici, B.A. (1997). Baculovirus Pathogenesis. In: Miller, L.K. (eds) The Baculoviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1834-5_3

Download citation

  • DOI: https://doi.org/10.1007/978-1-4899-1834-5_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1836-9

  • Online ISBN: 978-1-4899-1834-5

  • eBook Packages: Springer Book Archive