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Fimbrial Adhesins of Salmonella Typhimurium

Role in Bacterial Interactions with Epithelial Cells

  • Chapter
Mechanisms in the Pathogenesis of Enteric Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 412))

Summary

S. typhimurium initiates infection of its mammalian host by attachment to mucosal surfaces in the intestine and subsequent invasion of epithelial cells. To date, three S. typhimurium fimbrial operons, fim,1pf and pef, have been characterized. This analysis suggests that fimbrial adhesins fulfill multiple functions during the initial phase of an infection. In addition to their role in colonization of the small intestine, adhesins contribute to the tissue tropism for Peyer’s patches, which is characteristic for Salmonella infections. Furthermore, by mediating the initial contact to epithelial cells, fimbrial adhesins appear to be necessary for invasion and possibly for elicitation of an inflammatory response. Thus, fimbriae are important virulence factors of S. typhimurium and their future analysis promises to yield fascinating new insights into host-parasite interactions of this pathogen.

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Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Oregon Health Sciences University, 3181 S.W. Sam Jackson Park Road, L220, Portland, Oregon, 97201-3098, USA

    A. J. Bäumler, R. M. Tsolis & F. Heffron

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  1. A. J. Bäumler
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  2. R. M. Tsolis
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  3. F. Heffron
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Editors and Affiliations

  1. Iowa State University, Ames, Iowa, USA

    Prem S. Paul

  2. South Dakota State University, Brookings, South Dakota, USA

    David H. Francis  & David A. Benfield  & 

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Bäumler, A.J., Tsolis, R.M., Heffron, F. (1997). Fimbrial Adhesins of Salmonella Typhimurium . In: Paul, P.S., Francis, D.H., Benfield, D.A. (eds) Mechanisms in the Pathogenesis of Enteric Diseases. Advances in Experimental Medicine and Biology, vol 412. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1828-4_23

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  • DOI: https://doi.org/10.1007/978-1-4899-1828-4_23

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