The Occurrence of Nephritis Plasmin Binding Protein (SPEB) in the Extracellular Products of Group C Nephritogenic Streptococcus zooepidemicus

  • M. Barnham
  • F. Chapman
  • G. Cu
  • J. Afriyie
  • J. B. Zabriskie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 418)

Abstract

While the vast majority of cases of acute post-streptococcal glomerulonephritis (PSGN) in man are caused by infection with group A streptococci (GAS) there have been well-documented instances associated with non-GAS, in particular with the zoonotic group C Streptococcus zooepidemicus1, 2. Recent evidence (similiar molecular weight, serological response and localisation in biopsies) indicates that the nephritis strain-associated protein (NSAP)6, Vogt’s cationic protein7 and nephritis plasmin binding protein (NBPB)5 are in reality the same protein and identical to Elliot’s streptococcal proteinase3 or streptococcal pyrogenic exotoxin B (SPEB). These proteins are clearly distinct from streptokinase4. To date SPEB has not been reported in non-group A pyogenic streptococci. We have investigated both nephritogenic and apparently non-nephritogenic isolates of S. zooepidemicus for the presence of NPBP/SPEB.

Keywords

Pneumonia Meningitis Nephritis Glomerulonephritis Plasmin 

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • M. Barnham
    • 1
  • F. Chapman
    • 2
  • G. Cu
    • 2
  • J. Afriyie
    • 2
  • J. B. Zabriskie
    • 2
  1. 1.Department of MicrobiologyHarrogate General HospitalHarrogate, North YorkshireEngland
  2. 2.The Rockefeller UniversityNew YorkUSA

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