Group A and Group B Streptococcal Vaccine Development

A Round Table Presentation
  • J. B. Dale
  • P. P. Cleary
  • V. A. Fischetti
  • D. L. Kasper
  • J. M. Musser
  • J. B. Zabriskie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 418)


Over the last decade, tremendous progress has been made in the development of vaccines to prevent streptococcal diseases. The following summarizes the presentations of the round table at the International Lancefield Symposium in Paris. Dr. Kasper describes the most recent data from phase I clinical trials of conjugate group B polysaccharide vaccines. The remaining presentations outline five different strategies being used to develop group A streptococcal vaccines.


Capsular Polysaccharide Streptococcal Infection Hybrid Protein Polysaccharide Vaccine Conjugate Group 
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  1. 1.
    Kasper, D.L. Proceedings of the American Association of Physicians 107:369–373 (1995).Google Scholar
  2. 2.
    Paoletti, L.C., Wessels, M.R., Rodewald, A.K., Shroff, A.A., Jennings. HJ., Kasper, D.L. Infect Immun 62: 3236–3243 (1994).PubMedGoogle Scholar
  3. 3.
    Kasper, D.L., Paoletti, L.C., Wessels, M.R., Guttormsen, H.K., Carey, V.J., Jennings, H.J., Baker, C.J. J. Clin. Invest. In press (1996).Google Scholar
  4. 4.
    Phillips, G.N., Flicker, P.F., Cohen, C., Manjula, B.N., Fischetti, V.A. Proc. Natl. Acad. Sci. U.S.A. 78: 4689–4693 (1981).PubMedCrossRefGoogle Scholar
  5. 5.
    Dale, J.B., Seyer, J.M., Beachey, E.H. Clin. Res. 33:396A (1985).Google Scholar
  6. 6.
    Hollingshead, S.K., Fischetti, V.A., Scott, J.R. J. Biol. Chem. 261:1677–1686 (1986).PubMedGoogle Scholar
  7. 7.
    Bessen, D., Fischetti, V.A. Infect. Immun. 56:2666–2672 (1988).PubMedGoogle Scholar
  8. 8.
    Bessen, D., Fischetti, VA. J. Immunol. 146:1251–1256 (1990).Google Scholar
  9. 9.
    Bronze, M.S., McKinsey, D.S., Beachey, E.H., Dale, J.B. J. Immunol. 141:2767–2770 (1988).PubMedGoogle Scholar
  10. 10.
    Fischetti, V.A., Hodges, W.M., Hruby, D.E. Science 244:1487–1490 (1989).PubMedCrossRefGoogle Scholar
  11. 11.
    Pozzi, G., Contorni, M., Oggioni, M.R. et al. Infect. Immun. 60:1902–1907 (1992).PubMedGoogle Scholar
  12. 12.
    Pozzi, G., Oggioni, M.R., Manganelli, R., Fischetti, V.A. Res, Microhiol. 143:449–457 (1992).CrossRefGoogle Scholar
  13. 13.
    Medaglini, D, Pozzi, G., King, T.P., Fischetti, V.A. Proc. Natl. Acad. Sci. U.S.A. 92:6868–6872 (1995).PubMedCrossRefGoogle Scholar
  14. 14.
    Dale, J.B., Chiang, E.Y., Lederer, J.W. J. Immunol. 151:2188–2194 (1993).PubMedGoogle Scholar
  15. 15.
    Dale, J.B., Simmons, M., Chiang, E.C., Chiang, E.Y. Vaccine 14:944–948 (1996).PubMedCrossRefGoogle Scholar
  16. 16.
    Wexler, D.E., Chenoweth, E.D., Cleary, P. Proc. Natl. Acad. Sci. U.S.A. 82:8144–8148 (1985).PubMedCrossRefGoogle Scholar
  17. 17.
    Chmouryguina, I., Suvorov, A., Ferrieri, P., Cleary, P. Infect. Immunity, 64:2387–2390 (1996).Google Scholar
  18. 18.
    Yinduo, J., McLandsborough, L., Kondagunta, A., Cleary, P.P. Infect. Immun. 64:503–510(1996).Google Scholar
  19. 19.
    Musser, J.M. Streptococcal superantigen, mitogenic factor, and pyrogenic exotoxin B expressed by Streptococcus Pyogenes. Structure and function, p.281–319 (1996). In Leung, D.Y.M., Huber, B.T., Schlievert, P.M. (ed) Superantigens: structure, biology, and relevance to human disease. Marcel Dekker, Inc. New York.Google Scholar
  20. 20.
    Burns, E.J., Jr., Marciel, A.M., Musser, J.M. Infect. Immun. In press (1996).Google Scholar
  21. 21.
    Kapur, V., Maffei, J.T., Greer, R.S., Li L.L., Adams, G.J., Musser, J.M. Microb. Pathog. 16:443–450 (1994).PubMedCrossRefGoogle Scholar
  22. 22.
    Lancefield, R.C. J. Exp. Med. 10:271–292 (1959).CrossRefGoogle Scholar
  23. 23.
    Salvadori, L. et al. J. Infect. Dis. 171:593–600 (1995)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • J. B. Dale
    • 1
  • P. P. Cleary
    • 2
  • V. A. Fischetti
    • 3
  • D. L. Kasper
    • 4
  • J. M. Musser
    • 5
  • J. B. Zabriskie
    • 3
  1. 1.The University of TennesseeMemphisUSA
  2. 2.The University of MinnesotaMinneapolisUSA
  3. 3.Rockefeller UniversityNew YorkUSA
  4. 4.Harvard Medical SchoolBostonUSA
  5. 5.Baylor College of MedicineHoustonUSA

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