Virulence Mechanisms of Streptococcus suis

  • P. M. Norton
  • J. A. Leigh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 418)


Streptococcus suis is a common and widespread swine pathogen which also infects other species including man, causing cases of septicaemia, bronchopneumonia, arthritis and meningitis. Capsular type 2 is the most significant cause of disease in the U.K. and both virulent and avirulent strains have been isolated. The factors which confer virulence on S. suis type 2 are unknown although a number of virulence-associated proteins such as extracellular factor (EF) Muraminidase released protein (MRP)5, 3 and suilysin2 have been detected. We have developed a murine model to look at the differences in virulence between strains. In vitro assays which investigate the interaction between bacteria and phagocytic cells were used to study the basis of such differences.


Arthritis Chromium Penicillin Meningitis Encapsulation 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    C.X. Cao, C. Silverstein, H.C. Neu, and T.H. Steinberg. 1992. J. Infect. Dis. 165: 322–328.PubMedCrossRefGoogle Scholar
  2. 2.
    A.A.C. Jacobs, P.L.W. Loeffen, A.J.G. van den Berg and P.K. Storm. 1994. Infect. Immun. 62: 1742–1748.PubMedGoogle Scholar
  3. 3.
    S. Quessy, J.D. Dubreuil, M. Caya and R. Higgins. 1995. Infect. Immun. 63: 1975–1979.PubMedGoogle Scholar
  4. 4.
    P. Valentin-Weigand, P. Benkel, M. Rohde and G. S. Chhatwal. 1996. Infect. Immun. 64: 2467–2473.Google Scholar
  5. 5.
    U. Vecht, H.J. Wisselink, M.L. Jellema and H.E. Smith. 1991. Infect. Imnun. 59: 3156–3162.Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • P. M. Norton
    • 1
  • J. A. Leigh
    • 1
  1. 1.Compton LaboratoryInstitute for Animal HealthBerksUK

Personalised recommendations