Virulence Mechanisms of Streptococcus suis
Streptococcus suis is a common and widespread swine pathogen which also infects other species including man, causing cases of septicaemia, bronchopneumonia, arthritis and meningitis. Capsular type 2 is the most significant cause of disease in the U.K. and both virulent and avirulent strains have been isolated. The factors which confer virulence on S. suis type 2 are unknown although a number of virulence-associated proteins such as extracellular factor (EF) Muraminidase released protein (MRP)5, 3 and suilysin2 have been detected. We have developed a murine model to look at the differences in virulence between strains. In vitro assays which investigate the interaction between bacteria and phagocytic cells were used to study the basis of such differences.
KeywordsPhagocytic Cell Vitro Assay J774 Cell Adherent Bacterium Avirulent Strain
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