Genetic Analysis of the Surface Protein Antigen Gene Expression in Streptococcus mutans
Streptococcus mutans has produced several virulence factors such as glucosyltransferases, fructosyltransferase and a cell-surface protein antigen variously designated as antigen B, IF, I/II, PI, SR, MSL-1 and PAc. Hydrophobic interaction between PAc and acquired pellicles is considered to be important for the initial attachment of S. mutans to tooth surfaces. Although regulatory mechanisms controlling the expression of virulence genes in S. mutans have recently become a subject of considerable interest, the regulation of the expression of the pac gene is poorly understood. To analyze the mechanism of the pac gene expression, we have identified the promoter region of the gene.
KeywordsTranscriptional Start Site Streptococcus Mutans Primer Extension Analysis Primer Extension Product Potential Starting Codon
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