Surface Protein Expression in Group B Streptococcal Invasive Isolates
Group B streptococci (GBS) are important pathogens of newborn infants, causing sepsis and/or meningitis, of early-onset or late-onset. GBS also cause bacteremia in parturients, the elderly and the immunocompromised.1 Identification of GBS isolates is based on the type polysaccharide (serotypes Ia through VIII) and the surface-localized c and R proteins.1, 5 C protein includes two components: trypsin sensitive beta (β) and trypsin resistant alpha (α)5 while R includes four species, R1 through R4 and, like α, is trypsin-resistant.3 These proteins are of interest because of their possible role in GBS virulence and protective immunity.
KeywordsAgarose Polysaccharide Trypsin Polyacrylamide Resis
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