Surface Protein Expression in Group B Streptococcal Invasive Isolates
Group B streptococci (GBS) are important pathogens of newborn infants, causing sepsis and/or meningitis, of early-onset or late-onset. GBS also cause bacteremia in parturients, the elderly and the immunocompromised.1 Identification of GBS isolates is based on the type polysaccharide (serotypes Ia through VIII) and the surface-localized c and R proteins.1, 5 C protein includes two components: trypsin sensitive beta (β) and trypsin resistant alpha (α)5 while R includes four species, R1 through R4 and, like α, is trypsin-resistant.3 These proteins are of interest because of their possible role in GBS virulence and protective immunity.
KeywordsSurface Protein Expression Minnesota Medical School Type Polysaccharide Agarose Slide Polysaccharide Serotyping
Unable to display preview. Download preview PDF.
- 2.Flores, A.E. and P. Ferrieri. Molecular diversity among the trypsin resistant surface proteins of group B streptococci. Zbl. Bakt. (International Journal of Medical Microbiology, Virology, Parasitology & Infectious Diseases) 285: 44–51, 1996.Google Scholar
- 4.Flores, A.E. and P. Ferrieri. The type-specific polysaccharide and the R protein antigens of the L-phase from a group B, type III streptococcus. Zbl. Bakt. Hyg. A 259:165–178, 1985.Google Scholar