Superantigens of Group A Streptococci (Streptococcus pyogenes)

Distribution, Induction of Antibodies, and Binding to Human Cell Types
  • Barbara Wagner
  • Dieter Gerlach
  • Jörg-Hermann Ozegowski
  • Manfred Wagner
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 418)

Abstract

The erythrogenic (pyrogenic) toxins ETA and ETC have been characterized as superantigens, which bind as native molecules to MHC class II molecules of antigen processing cells and to T-cell receptors possessing specific Vß-chains. Linking these two receptors results in a high release of cytokines. ETB was recognized as the precursor of the streptococcal proteinase. Mitogenic activity detected in preparations of ETB by some authors was found to be a contamination, recently isolated and described as toxin AX (1). It is accompanied by a second component BX, which differs only by the lack of the amino terminal arginine. The immunological reactions of both proteins are identical, but the mitogenic activity of BX is failed higher than that of AX.

Keywords

Lymphoma Electrophoresis Arginine Prefix 

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References

  1. 1.
    Gerlach, D., E. Günther, W. Köhler, S. Vettermann. B. Fleischer, and K.-H. Schmidt: Isolation and characterization of a mitogen characteristic of group A streptococci (Streptococcus pyogenes). Zbl. Bakt. 282: 67–82 (1995)Google Scholar
  2. 2.
    Wagner, B., M. Buslau. D. Gerlach, A. Ramirez-Bosca, R. Stracke, and M. Wagner: Binding of Streptococcus pvogenes erythrogenic toxin A to CD1a-positive and CD1a-negative human epidermal cells and to dermal fibroblasts. Europ. J. Dermatol. 3: 704–708 (1993)Google Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Barbara Wagner
    • 1
  • Dieter Gerlach
    • 1
  • Jörg-Hermann Ozegowski
    • 1
  • Manfred Wagner
    • 1
  1. 1.Institute of Experimental MicrobiologyFriedrich-Schiller-UniversityJenaGermany

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