Penicillin Tolerance in Group A Streptococci

  • Gülnur Dündar
  • K. Funda Babacan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 418)


Penicillin is the drug of choice for the treatment of streptococcal pharyngitis. However, during the last years, several studies has shown tolerance to penicillin as one of the major causes of treatment failure5. Tolerance to penicillin, namely, a significantly decreased bactericidal effect on the organisms, is often defined by macrodilution method as the ratio of the minimal bactericidal concentration to the minimal inhibitory concentration (MBC/MIC ratio) being 321. Because of the importance of penicillin tolerance in the failure of treatment of streptococcal pharyngitis there have been a number of studies which have looked at the frequency distribution of tolerance. However, these studies have mainly been conducted in closed community situations. The purpose of this study was to investigate the frequency distribution of penicilin tolerance in the community at large.


Minimal Inhibitory Concentration Minimal Bactericidal Concentration Blood Agar Plate Streptococcal Pharyngitis Closed Community 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Gülnur Dündar
    • 1
  • K. Funda Babacan
    • 1
  1. 1.Department of MicrobiologyMarmara UniversityTurkey

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