Nitric Oxide Rather than Superoxide or Peroxynitrite Inhibits Insulin Secretion and Causes DNA Damage in HIT-T15 Cells
We have previously demonstrated that treatment of rat islets of Langerhans with the nitric oxide donors 3-morpholinosydnonimine (SIN-1) and S-nitrosoglutathione (GSNO) inhibits insulin secretion and increases cyclic GMP, thus mimicking the effects of the cytokine interleukin-lβ  and . We have recently found that nitric oxide, derived exogenously from nitric oxide donors or endogenously by IL-lβ induction of nitric oxide synthase, causes DNA damage in islets of Langerhans and in HIT-T15 cells when measured by the ‘comet’ assay .
KeywordsNitric Oxide Insulin Secretion Comet Tail Nitric Oxide Donor Inhibit Insulin Secretion
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