Abstract
Single pancreatic β-cells are heterogeneous, the following are observations of β-cell variability: insulin content and biosynthesis of individual β-cells (Pipeleers, 1987; Schuit et al., 1988), glucose transport (Tominaga et al., 1986), electrical activity (Dean and Mattews, 1970; Ashcroft et al., 1987) and insulin secretion (Salomon and Meda, 1986; Hiriart and Matteson, 1988; Hiriart and Ramirez-Medeles, 1991; Van Schravendijk et al., 1992).
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Ammon, H.P.T., Glocker, C., Waldner, R.G., and Wahl, M.A., 1989, Insulin release from pancreatic islets of fetal rats mediated by leucine b-BCH, tolbutamide, glibenclamide, arginine, potassium chloride, and theophylline does not require stimulation of Ca2+ net uptake, Cell Calcium 10:441–450.
Ashcroft, F.M., Harrison, D.E., Ashcroft, S.J.H., 1987, A potassium channel modulated by glucose metabolism in rat pancreatic B-cells, in “Biophysics of the Pancreatic B-Cells,” I. Atwater, E. Rojas, B. Soria, eds., Plenum Press, New York.
Dean, P.M., and Mattews, E.K., 1970, Glucose-induced electrical activity in pancreatic islet cells, J. Physiol 210: 255–264.
Hiriart, M. and Ramírez-Medeles, M.C., 1991, Functional subpopulations of individual pancreatic B-cells in culture, Endocrinology 128: 3193–3198.
Hiriart, M., and Ramírez-Medeles, M.C., 1993, Muscarinic modulation of insulin secretion by single pancreatic B-cells, Mol. and Cellular Endocrinology 93: 63–69.
Hiriart, M., and Matteson, D.R., 1988, Na channels and two types of Ca channels in rat pancreatic B cells identified with the reverse hemolytic plaque assay, J. Gen. Physiol. 91: 617–639.
Horta, J., Hiriart, M. and Cota, G., 1991, Differential expression of Na channels in functional subpopulations of rat lactotropes, Am. J. Physiol. 261: C865–C871.
Neill, J.D., and Frawley, L. S., 1983, Detection of hormone release from individual cells in mixed populations using a reverse hemolytic plaque assay, Endocrinology 112: 1135–1137.
Pipeleers, D., 1987, The biosociology of pancreatic B cells, Diabetologia 30:277–291.
Salomon, D., and Meda, P., 1986, Heterogeneity and contact-dependent regulation of hormone secretion by individual B cells, Exp. Cell. Res. 162:507–520.
Schuit, F.C., In’tVeld, P.A., and Pipeleers, D.G., 1988, Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells, Proc. Natl. Acad. Sci. USA. 85: 3865–3869.
Tominaga, M., Komiya, I., Johnson, J.H., Inman, L., Alam, T., Moltz, J., Crider, B., Stefan, Y., Baetens, D., McCorkle, K., Orci, L., and Unger, R.H., 1986, Loss of insulin response to glucose but not arginine during the development of auto immune diabetes in BB/W rats: relationships to islet volume and glucose transport rate, Proc. Natl. Acad. Sci. USA. 83:9749–9753.
Van Schravendijk, C.F.H., Kiekens, R., and Pipeleers, D.G., 1992, Pancreatic β cell heterogeneity in glucose-induced insulin secretion, J. Biol. Chem. 267: 21344–21348.
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© 1997 Springer Science+Business Media New York
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Hiriart, M., Martinez, M.T., Ramírez-Medeles, M.d.C. (1997). Physiological Behavior of Functional Subpopulations of Single Pancreatic β-Cells. In: Soria, B. (eds) Physiology and Pathophysiology of the Islets of Langerhans. Advances in Experimental Medicine and Biology, vol 426. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1819-2_37
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DOI: https://doi.org/10.1007/978-1-4899-1819-2_37
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