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Immunological Analysis of G-Protein Expression in the Endocrine Pancreas

  • Nicholas S. Berrow
  • Rosemary J. Lacey
  • Ian J. White
  • Noel G. Morgan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 426)

Abstract

Inhibition of insulin secretion by agonists acting at cell surface receptors (e.g. α2-agonists, somatostatin, galanin) is mediated by one or more guanine-nucleotide binding (G) proteins that serve as substrates for pertussis toxin1. Recent work has established that a family of such proteins exist and that at least 3 subtypes (Gi2 and two forms of Go) are present in rat islet cells2,3.

Keywords

Insulin Secretion Pertussis Toxin RINm5F Cell Galanin Receptor Normal Islet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Nicholas S. Berrow
    • 1
  • Rosemary J. Lacey
    • 1
  • Ian J. White
    • 1
  • Noel G. Morgan
    • 1
  1. 1.Cellular Pharmacology Group, Department of Biological SciencesKeele UniversityKeele, StaffsUK

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