Abstract
Pickles (1967) proposed that up to four different prostanoid types existed. Coleman et al. (1984) developed a working classification for the prostanoid receptors and since then there has been some debate concerning heterogeneity of each receptor. Following on from these studies, extensive work has led to systematic prostanoid receptor classification. The present prostanoid receptor classification is a simple systematic working hypothesis whereby each of the natural prostanoids has its own receptor termed a P receptor where it is at least ten times more potent than any of the other natural prostanoids. Thus the prostaglandin E2 (PGE2)-sensitive receptors are termed the EP-receptors, PGF2α FP-receptors, PGD2, DP-receptors, PGI2, IP receptors and the thromboxane A2 (TXA2)-sensitive receptors, TP-receptors (Kennedy et al., 1982). The thromboxane receptor (TP) has been shown to mediate constriction of airway and vascular smooth muscle as well as platelet aggregation but discussion has failed to resolve the number of receptors involved.
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Abbas, F. et al. (1997). A Comparative Study of Thromboxane (TP) Receptor Mimetics and Antagonists on Isolated Human Umbilical Artery and Myometrium. In: Honn, K.V., Marnett, L.J., Nigam, S., Jones, R.L., Wong, P.YK. (eds) Eicosanoids and other Bioactive Lipids in Cancer, Inflammation, and Radiation Injury 3. Advances in Experimental Medicine and Biology, vol 407. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1813-0_33
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