EGF-Receptor Tyrosine Kinase and 12-Lipoxygenase Activity Regulate Expression of 12-Lipoxygenase in Human Tumor Cells

  • Wolfgang Hagmann
  • Susanne Borgers
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 407)


Various human tumor cells including the epidermoid carcinoma A431 cells express the platelet-type isoform of 12-lipoxygenase (12-LOX)1–3. Tumor cell 12-LOX and the arachidonate metabolite generated via 12-LOX activity, 12(S)-HETE, have been shown to contribute to the metastatic potential of tumor cells in vivo and in vitro 4. Most recently, elevated expression of 12-LOX mRNA in prostate epithelial cells was demonstrated to correlate with poor prognosis in human prostate cancer5.


Epidermal Growth Factor A431 Cell A431 Tumor Cell Epidermoid Carcinoma A431 Cell Arachidonate Metabolite 
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  1. 1.
    T. Izumi, S. Hoshiko, O. Rádmark, and B. Samuelsson. Proc. Natl. Acad. Sci. U.S.A. 87:7477 (1990).PubMedCrossRefGoogle Scholar
  2. 2.
    W.-C. Chang, C.-C. Ning, M.T. Lin, and J.-D. Huang. J. Biol. Chem. 267:3657 (1992).PubMedGoogle Scholar
  3. 3.
    Y.Q. Chen, Z.M. Duniec, B. Liu, W. Hagmann, X. Gao, L.J. Marnett, C.R. Johnson, and K.V. Honn. Cancer Res. 54:1574 (1994).PubMedGoogle Scholar
  4. 4.
    K.V. Honn, D.G. Tang, X. Gao, I.A. Butovich, B. Liu, J. Timar, and W. Hagmann. Cancer Metastasis Rev. 13:365 (1994).PubMedCrossRefGoogle Scholar
  5. 5.
    X. Gao, D. Grignon, T. Chbihi, and K.V. Honn. Urology, in press (1995).Google Scholar
  6. 6.
    W. Hagmann, X. Gao, J. Timar, Y.Q. Chen, A.-R. Strohmaier, C. Fahrenkopf, D. Kagawa, M. Lee, A. Zacharek, and K.V. Honn. Biochem. J. in press (1995).Google Scholar
  7. 7.
    W.C. Chang, Y.W. Liu, C.C. Ning, H. Suzuki, T. Yoshimoto, and S. Yamamoto. J. Biol. Chem. 268:18734 (1993).PubMedGoogle Scholar
  8. 8.
    S. Clark, and M. Dunlop. Biochem. J. 274:715 (1991).PubMedGoogle Scholar
  9. 9.
    S. Nishibe, M.I. Wahl, S.M.T. Hernandez-Sotomayor, N.K. Tonks, S.G. Rhee, and G. Carpenter. Science 250:1253 (1990).PubMedCrossRefGoogle Scholar
  10. 10.
    G.J. Fisher, P.A. Henderson, J.J. Vorhees, and J.J. Baldassare. J. Cell. Physiol. 146:309 (1991).PubMedCrossRefGoogle Scholar
  11. 11.
    W.C. Glasgow, C.A. Afshari, J.C. Barrett, and T.E. Eling. J. Biol. Chem. 267:10771 (1992).PubMedGoogle Scholar
  12. 12.
    M.M. Bradford. Anal. Biochem. 72:248 (1976).PubMedCrossRefGoogle Scholar
  13. 13.
    B. Liu, J. Timar, J. Howlett, C.A. Diglio, and K.V. Honn. Cell Regulation 2:1045 (1991).PubMedGoogle Scholar
  14. 14.
    W. Hagmann, D. Kagawa, C. Renaud, and K.V. Honn. Prostaglandins 46:471 (1993).PubMedCrossRefGoogle Scholar
  15. 15.
    B.L. Margolis, J.V Bonventre, S.G. Kremer, J.E. Kudlow, and K.L. Skorecki. Biochem. J. 249:587 (1988).PubMedGoogle Scholar
  16. 16.
    N. Hack, B. Margolis, J. Schlessinger, and K. Skorecki. J. Basic and Clin. Physiol. and Pharmacol. 2:161 (1991).Google Scholar
  17. 17.
    W. Hagmann. Unpublished observation (1995).Google Scholar
  18. 18.
    Y.-W. Liu, Y. Asaoka, H. Suzuki, T. Yoshimoto, S. Yamamoto, and W.-C. Chang. J. Pharmacol. Exp. Ther. 271:567 (1994).PubMedGoogle Scholar
  19. 19.
    D.W. Fry, A.J. Kraker, A. McMichael, L.A. Ambroso, J.M. Nelson, W.R. Leopold, R.W. Connors, and A.J. Bridges. Science 265:1093 (1994).PubMedCrossRefGoogle Scholar
  20. 20.
    E. Buchdunger, U. Trinks, H. Mett, U. Regenass, M. Müller, T. Meyer, E. McGlynn, L.A. Pinna, P. Traxler, and N.B. Lydon. Proc. Natl. Acad. Sci. USA 91:2334 (1994).PubMedCrossRefGoogle Scholar
  21. 21.
    X. Gao, Y.Q. Chen, W. Hagmann, J. Timar, A. Zacharek, C. Renaud, M. Lee, and K.V. Honn. Proc. Am. Assoc. Cancer Res. 35:605 (1994).Google Scholar
  22. 22.
    T. Arakawa, M. Nakamura, T. Yoshimoto, and S. Yamamoto. FEBS Lett. 363:105 (1995).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Wolfgang Hagmann
    • 1
  • Susanne Borgers
    • 1
  1. 1.Division of Tumor BiochemistryDeutsches KrebsforschungszentrumHeidelbergGermany

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