Human Beta-Trace in Normal and Pathological CNS Tissues, Genital Organs and Body Fluids

  • Jan-Edvin Olsson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 433)


Beta-trace protein (BTP) was first described by Clausen 1961 (1) as one or two extra bands found in cerebrospinal fluid (CSF) when tested with immunoprecipitation using an antiserum against human CSF. Later on, BTP could also be discovered in blood, urine and other body fluids (2). The concentration of BTP was found to be about 10 x that in serum and in healthy adult persons between 26 and 40 mg/l (3). The serum concentration of BTP was less than 5 mg/l and the 24 hour urine excretion was found to be less than 100 mg/l (4). BTP is one of the major proteins of the CSF constituting about 6% of the total protein content, a migrates as three or more bands in the gammaregion of a regular CSF electrophoresis (5). Almost equal amounts of CSF-BTP have also been found in seminal and amniotic fluids (6, 7). In seminal fluid there is a correlation between the BTP concentration and the number of spermatozoa with lowest BTP values found in patients with azospermia (6). In samples of amniotic fluid the BTP concentration increases with gestational age, but no correlation could be found to neural tube defects (8).


Amniotic Fluid Neural Tube Defect Squirrel Monkey Seminal Fluid Genital Organ 
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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Jan-Edvin Olsson
    • 1
  1. 1.Department NeurologyUniversity HospitalLinköpingSweden

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