The Production of Eicosanoid Precursors by Mucoralean Fungi

  • Alfred Botha
  • J. Lodewyk F. Kock
  • Santosh Nigam
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 433)


Eicosanoid precursors for commercial utilization are currently obtained predominantly from animal sources (Ratledge, 1994). However, the mucoralean fungi turned out to be an alternative source (Shimizu and Yamada, 1989; Ratledge, 1994). These fungi are more suitable for the production of large quantities of eicosanoid precursors, such as arachidonic acid [20: 4(ω6)], dihomo-gamma-linolenic acid [20: 3(ω6)], eicosapentaenoic acid [20: 5(ω3)] and gamma-linolenic acid [18: 3(ω6)]. In order to develop commercial biotechnological processes, it is necessary that favourable fungal strains are selected and that these are screened for the production of eicosanoid precursors from more affordable substrates. The present study reviews the pivotal role of mucoralean fungi in the production of eicosanoid precursors.


Eicosapentaenoic Acid Cocoa Butter United States Patent Genus Mucor Cocoa Butter Equivalent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • Alfred Botha
    • 1
  • J. Lodewyk F. Kock
    • 1
  • Santosh Nigam
    • 2
  1. 1.Dept. of Microbiology and BiochemistryUniversity of the Free StateSouth Africa
  2. 2.Eicosanoid Research Div., Dept. of GynaecologyUniv.- Klinikum Benjamin Franklin, Free University BerlinBerlinGermany

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