Abstract
Alzheimer’s disease (AD) is the leading cause of dementia in the elderly, affecting over 4 million individuals in the United States at an estimated annual cost of $100 billion. AD typically presents with memory loss followed by progressive cognitive deterioration over a period of 5 to 10 years. This clinical pattern is mirrored by neuropathology first in the hippocampus and associated structures with later involvement of cortical regions and some subcortical nuclei. Recent research efforts have lead to significant advances in our understanding of the genetics and pathological hallmarks of AD. However, we still do not understand the cause(s) of this disease, and current therapeutic interventions do not influence the overall progression of AD.
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Bauer, M.K.A., Lieb, K., Schulzeostohoff, K., Berger, M., Gebicke-Haerter, P.J., Bauer, J., and Fiebich, B.L., 1997, Expression and regulation of cyclooxygenase-2 in rat microglia, Eur. J. Biochem. 243: 726.
Breder, C.D., DeWitt, D., and Kraig, R.P., 1995, Characterization of inducible cyclooxygenase in rat brain, J. Comp. Nenrol. 355: 296.
Breitner, J.C.S., 1996, Inflammatory processes and antiinflammatory drugs in Alzheimer’s disease: a current appraisal, Neurobiol. Aging 17: 789.
Chang, J.W., Coleman, P.D., and O’Banion, M.K., 1996, Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer’s disease, Neurobiol. Aging 17: 801.
Fiebich, B.L., Biber, K., Lieb, K., van Calker, D., Berger, M., Bauer, J., and Gebicke-Haerter, P.J., 1996, Cyclooxygenase-2 expression in rat microglia is induced by adenosine A2a-receptors, Glia 18: 152.
Kaufmann, W.E., Worley, P.F., Pegg, J., Bremer, M., and Isakson, P., 1996, Cox-2, a synaptically-induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex, Proc. Natl. Acad. Sci. USA 93: 2317.
McGeer, P.L., and McGeer, E.G., 1995, Chronic inflammatory mechanisms of the brain: implications for he treatment of Alzheimer disease, Dementia 9: 111.
Minghetti, L., Polazzi, E., Nicolini, A., Créminon, C., and Levi, G., 1996, Interferon gamma and nitric oxide down-regulate lipopolysaccharide-induced prostanoid production in cultured rat microglial cells by inhibiting cyclooxygenase-2 expression, J. Neurochem. 66: 1963.
O’Banion, M.K., Coleman, P.D., and Callahan, L.M., 1994, Regional neuronal loss in aging and Alzheimer’s disease: a brief review, Sem. Neurosci. 6: 307.
O’Banion, M.K., Dusel, J.C., Chang, J.W., Kaplan, M.D., and Coleman, P.D., 1996, Interleukin-1ß induces prostaglandin G/H synthase-2 (cyclooxygenase-2) in primary murine astrocyte cultures, J. Neurochem. 66: 2532.
O’Banion, M.K., Winn, V.D., and Young, D.A., 1992, cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase, Proc. Natl. Acad. Sci. USA 89: 4888.
Rogers, J., Kirby, L.C., Hempelman, S.R., Berry, D.L., McGeer, P.L., Kasznaik, A.W., Zalinski, J., Cofield, M., Mansukhani, L., Willson, P., and Kogan, F., 1993, Clinical trial of indomethacin in Alzheimer’s disease, Neurology 43: 1609.
Rogers, J., Webster, S., Lue, L.-F., Brachova, L., Civin, W.H., Emmerling, M., Shivers, B., Walker, D., and McGeer, P., 1996, Inflammation and Alzheimer’s disease pathogenesis, Neurobiol. Aging 17: 681.
Stewart, W.F., Kawas, C., Corrada, M., and Metter, E.J., 1997, Risk of Alzheimer’s disease and duration of NSAID use, Neurology 48: 626.
Terry, R.D., Masliah, E., Salmon, D.P., Butters, N., DeTeresa, R., Hill, R., Hansen, L.A., and Katzman, R., 1991, Physical basis of cognitive alterations in Alzheimer’s disease: synapse loss is the major correlate of cognitive impairment, Ann. Neurol. 30: 572.
Yamagata, K., Andreasson, K.I., Kaufmann, W.I., Barnes, C.A., and Worley, P.F., 1993, Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids, Neuron 11: 371.
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O’Banion, M.K., Chang, J.W., Kaplan, M.D., Yermakova, A., Coleman, P.D. (1997). Glial and Neuronal Expression of Cyclooxygenase-2: Relevance to Alzheimer’S Disease. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_36
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_36
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