Abstract
Sulfidopeptide leukotrienes (sLT) are arachidonic acid (AA) metabolites involved in the inflammatory response (Dahlen, 1981). LT production from the unstable metabolic intermediate LTA4 is cell-type dependent, as polymorphonuclear leukocytes (PMNL) generate predominantly LTB4 while LTC4 is the main product synthesized by eosinophils and mast cells; in addition, cooperation between PMNL (donor cells for LTA4) and endothelial cells (EC, acceptor cells) leads to formation of LTC4 by “transcellular biosynthesis” (Feinmark, 1986; Maclouf, 1989).
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Buccellati, C., Rossoni, G., Berti, F., Folco, G. (1997). Modulation of Leukocyte-Endothelial Cell Interaction and Leukotriene Dependent Vasoconstriction by Prostacyclin Mimetics in the Isolated Rabbit Heart. In: Sinzinger, H., Samuelsson, B., Vane, J.R., Paoletti, R., Ramwell, P., Wong, P.YK. (eds) Recent Advances in Prostaglandin, Thromboxane, and Leukotriene Research. Advances in Experimental Medicine and Biology, vol 433. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1810-9_22
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DOI: https://doi.org/10.1007/978-1-4899-1810-9_22
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