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The GABAA Receptors

From Subunits to Diverse Functions

  • Chapter
Ion Channels

Part of the book series: Ion Channels ((IC,volume 4))

Abstract

Transmitter-gated ion channels are multisubunit membrane-spanning receptors that serve as rapid signal transduction devices regulating the flow of cations or anions through the cell membrane. Cell type—specific flexibility in neurotransmission is accomplished by a multiplicity of channel variants based on the combinatorial assembly of structurally related subunits. The heteromeric subunit structure also permits synaptic plasticity by changes in subunit composition and subunit-specific posttranslational modification. In addition, receptor heterogeneity offers the potential for cell type-specific drug targeting.

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Authors and Affiliations

  1. Institute of Pharmacology, Federal Institute of Technology (ETH), CH-8057, Zurich, Switzerland

    H. Mohler, J. M. Fritschy, B. Lüscher, U. Rudolph, J. Benson & D. Benke

  2. University of Zurich, CH-8057, Zurich, Switzerland

    H. Mohler, J. M. Fritschy, B. Lüscher, U. Rudolph, J. Benson & D. Benke

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  1. H. Mohler
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  2. J. M. Fritschy
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  3. B. Lüscher
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  1. Northwestern University Medical School, Chicago, Illinois, USA

    Toshio Narahashi

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Mohler, H., Fritschy, J.M., Lüscher, B., Rudolph, U., Benson, J., Benke, D. (1996). The GABAA Receptors. In: Narahashi, T. (eds) Ion Channels. Ion Channels, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1775-1_3

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