Advertisement

Plant Acyl-ACP Thioesterases: Chain-Length Determining Enzymes in Plant Fatty Acid Biosynthesis

  • Toni Voelker
Chapter
Part of the Genetic Engineering book series (GEPM, volume 18)

Abstract

De novo plant fatty acid biosynthesis takes place in an organelle, the plastid. Acyl chains are elongated by 6 to 7 dissociable enzymes, together constituting a so-called type II fatty acid synthase. During the extension cycles the acyl chains are covalently bound, via a thioester, to the prosthetic group of a small, soluble, acyl carrier protein (ACP; 78 amino acid residues) (1,2). Taken together, these features make the plant fatty acid synthase distinct from the cytoplasmic, multi-subunit fatty acid synthase of animals and fungi (type I), but quite similar to the one common in prokaryotes (3). This functional similarity is one of the many vestiges of the prokaryotic ancestry of the plastids, which descended from cyanobacterial endosymbionts (4).

Keywords

Fatty Acid Biosynthesis Transit Peptide Medium Chain Petroselinic Acid International Patent Application 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ohlrogge, J. and Browse, J. (1995) Plant Cell 7, 957–970.PubMedGoogle Scholar
  2. 2.
    Gibson, S., Falcone, D.L., Browse, J. and Somerville, C. (1994) Plant, Cell and Environment 17, 627–637.CrossRefGoogle Scholar
  3. 3.
    Ohlrogge, J.B. (1982) TIBS 7, 386–387.Google Scholar
  4. 4.
    Gray, M.W. (1989) Trends Genet. 5, 294–295.PubMedCrossRefGoogle Scholar
  5. 5.
    Roughan, P.G. and Slack, C.R. (1982) TIBS 9, 383–386.Google Scholar
  6. 6.
    Löhden, I. and Frentzen, M. (1988) Planta 176, 506–512.CrossRefGoogle Scholar
  7. 7.
    Shine, W.E., Mancha, M. and Stumpf, P.K. (1976) Arch. Biochem. Biophys. 172, 110–116.PubMedCrossRefGoogle Scholar
  8. 8.
    Ohlrogge, J.B., Shine, W.E. and Stumpf, P.K. (1978) Arch. Biochem. Biophys. 189, 382–391.PubMedCrossRefGoogle Scholar
  9. 9.
    Stumpf, P.K. (1981) TIBS 6, 173–176.Google Scholar
  10. 10.
    Hilditch, T.P. and Williams, P.N. (1964) The Chemical Constitution of Natural Fats. Chapman and Hall, London.Google Scholar
  11. 11.
    McKeon, T.A. and Stumpf, P.K. (1982) J. Biol. Chem. 257, 12141–12147.PubMedGoogle Scholar
  12. 12.
    Oo, K.-C. and Stumpf, P.K. (1979) Lipids 14, 132–143.CrossRefGoogle Scholar
  13. 13.
    Harwood, J.L. (1988) Annu. Rev. Plant Physiol. Plant Mol. Biol. 39, 101–138.CrossRefGoogle Scholar
  14. 14.
    Jones, A., Davies, H.M. and Voelker, T.A. (1995) Plant Cell 7, 359–371.PubMedGoogle Scholar
  15. 15.
    Knauf, V.C. (1987) Trends Biotechnol. 5, 40–46.CrossRefGoogle Scholar
  16. 16.
    Battey, J.F., Schmid, K.M. and Ohlrogge, J.B. (1989) Trends Biotechnol. 7, 122–126.CrossRefGoogle Scholar
  17. 17.
    Slabas, A., Roberts, P. and Osmesher, J. (1982) in Biochemistry and Metabolism of Plant Lipids (Wintermans, J.F.G.M. and Kuiper, P.J.C., eds.), pp. 251–256, Elsevier, Amsterdam.Google Scholar
  18. 18.
    Pollard, M.R. and Singh, S.S. (1987) in The Metabolism, Structure and Function of Plant Lipids (Stumpf, P.K., Mudd, J.B. and Ness, W.D., eds.), pp. 455–463, Plenum Press, New York, NY.CrossRefGoogle Scholar
  19. 19.
    Pollard, M.R., Anderson, L., Fan, C., Hawkins, D.J. and Davies, H.M. (1991) Arch. Biochem. Biophys. 284, 306–312.PubMedCrossRefGoogle Scholar
  20. 20.
    Davies, H.M., Anderson, L., Fan, C. and Hawkins, D.J. (1991) Arch. Biochem. Biophys. 290, 37–45.PubMedCrossRefGoogle Scholar
  21. 21.
    Gould, S.J., Subramani, S. and Scheffler, I.E. (1989) Proc. Nat. Acad. Sci. U.S.A. 86, 1934–1938.CrossRefGoogle Scholar
  22. 22.
    Davies, H.M., Pollard, M., Voelker, T.A. and Thompson, G.A. (1991) International Patent Application No. WO-91–16421. Published October 31, 1991.Google Scholar
  23. 23.
    Voelker, T.A., Worrell, A.C., Anderson, L., Bleibaum, J., Fan, C., Hawkins, D., Radke, S. and Davies, H.M. (1992) Science 257, 72–74.PubMedCrossRefGoogle Scholar
  24. 24.
    deBoer, A.D. and Weisbeek, P.J. (1991) Biochim. Biophys. Acta 1071, 221–253.CrossRefGoogle Scholar
  25. 25.
    Voelker, T.A. and Davies, H.M. (1994) J. Bacteriol. 176, 7320–7327.PubMedGoogle Scholar
  26. 26.
    Kridl, J.C., McCarter, D.W., Rose, R.E., Scherer, D.E., Knutzon, D.S., Radke, S.E. and Knauf, V.C. (1991) Seed Sci. Res. 1, 209–219.CrossRefGoogle Scholar
  27. 27.
    Hitz, W.D. and Yadav, N.S. (1992) International Patent Application No. WO 92/11373. Published July 9, 1992.Google Scholar
  28. 28.
    Yadav, N., Wierzbicky, A., Knowlton, S., Pierce, J., Ripp, K., Hitz, W., Aegerter, M. and Browse, J. (1993) in Biochemistry and Molecular Biology of Membrane and Storage Lipids of Plants (Murata, N. and Somerville, C.R., eds.), Vol. 9, pp. 60–66, The American Society of Plant Physiologists, Rockville, MD.Google Scholar
  29. 29.
    Knutzon, D.S., Bleibaum, J.L., Nelsen, J., Kridl, J.C. and Thompson, G.A. (1992) Plant Physiol. 100, 1751–1758.PubMedCrossRefGoogle Scholar
  30. 30.
    Kinney, T. (personal communication).Google Scholar
  31. 31.
    Helleyer, A., Leadlay, P.F. and Slabas, A.R. (1992) Plant Mol. Biol. 20, 763–780.CrossRefGoogle Scholar
  32. 32.
    Loader, N.M., Woolner, E.M., Hellyer, A., Slabas, A.R. and Safford, R. (1993) Plant Mol. Biol. 23, 769–778.PubMedCrossRefGoogle Scholar
  33. 33.
    Dörmann, P., Frentzen, M. and Ohlrogge, J.B. (1994) Plant Physiol. 104, 839–844.PubMedGoogle Scholar
  34. 34.
    Dörmann, P., Kridl, J.C. and Ohlrogge, J.B. (1994) Biochim. Biophys. Acta 1212, 134–136.PubMedCrossRefGoogle Scholar
  35. 35.
    Chase, M.W., Soltis, D.E., Olmstead, R.G., Morgan, D., Les, D.H., Mishler, B.D., Duvall, M.R., Price, R.A., Hills, H.G., Qiu, Y.-L., Kron, K.A., Rettig, J.H., Conti, E., Palmer, J.D., Manhart, J.R., Sytsma, K.J., Michaels, H.J., Dress, W.J., Karol, K.G., Clark, W.D., Hedrén, M., Gaut, B.S., Jansen, R.K., Kim, K.-J., Wimpee, CF., Smith, J.F., Furnier, G.R., Strauss, S.H., Xiang, Q.-Y., Plunkett, G.M., Soltis, P.S., Swensen, S.M., Williams, S.E., Gadek, P.A., Quin, C.J., Eguiarte, L.E., Golenberg, E., Jr, G.H.L., Graham, S.W., Barrett, S.C.H., Dayanandan, S. and Albert, V.A. (1993) Annu. Missouri Bot. Gard. 80, 528–580.CrossRefGoogle Scholar
  36. 36.
    Amy, C.M., Witkowski, A., Naggert, J., Williams, B., Randhawa, Z. and Smith, S. (1989) Proc. Nat. Acad. Sci. U.S.A. 86, 3114–3118.CrossRefGoogle Scholar
  37. 37.
    Chirala, S.S., Kuziora, M.A., Spector, D.M. and Wakil, S.J. (1987) J. Biol. Chem. 262, 4231–4240.PubMedGoogle Scholar
  38. 38.
    Graham, S.A., Hirsinger, F. and Röbbelen, G. (1981) Amer. J. Bot. 68, 908–917.CrossRefGoogle Scholar
  39. 39.
    Voelker, T.A., Yuan, L., Kridl, J. and Hawkins, D. (1995) International Patent Application No. WO-95–13390. Published May 18, 1995.Google Scholar
  40. 40.
    Fillatti, J.A., Knutzon, D. and Dehesh, K. (1995) Poster at the NPLC workshop “Biochemistry and molecular biology of plant fatty acids and glycerolipids”, June 1–4, 1995, South Lake Tahoe, CA.Google Scholar
  41. 41.
    Grellet, F., Cooke, R., Raynal, M., Laudié, M. and Delseney, M. (1993) Plant Physiol. Biochem. 31, 599–602.Google Scholar
  42. 42.
    Dörmann, P., Voelker, T.A. and Ohlrogge, J.B. (1995) Arch. Biochem. Biophys. 316, 612–618.PubMedCrossRefGoogle Scholar
  43. 43.
    Töpfer, R., Martini, N. and Schell, J. (1995) International Patent Application No. WO 95/06740. Published March 9, 1995.Google Scholar
  44. 44.
    Frohman, M.A., Dush, M.K. and Martin, G.R. (1988) Proc. Nat. Acad. Sci. U.S.A. 85, 8998–9002.CrossRefGoogle Scholar
  45. 45.
    Graham, S.A. (1989) Crit. Rev. Food Sci. Nutr. 28, 139–173.PubMedCrossRefGoogle Scholar
  46. 46.
    Martini, N., Schell, J. and Töpfer, R. (1995) in Plant Lipid Metabolism (Kader, J.-C and Mazliak, P., eds.), pp. 495–498, Kluwer Academic Publishers, Netherlands.CrossRefGoogle Scholar
  47. 47.
    Morden, C.W. and Golden, S.S. (1989) Nature 337, 382–384.PubMedCrossRefGoogle Scholar
  48. 48.
    Fitch, W.M. (1970) System. Zool. 19, 99–113.CrossRefGoogle Scholar
  49. 49.
    Sanderson, M.J. and Donoghue, M.J. (1994) Science 264, 1590–1593.PubMedCrossRefGoogle Scholar
  50. 50.
    Martin, W., Gierl, A. and Saedler, H. (1989) Nature 339, 46–48.CrossRefGoogle Scholar
  51. 51.
    Voelker, T.A. (unpublished data).Google Scholar
  52. 52.
    Dehesh, K., Jones, A., Knutzon, D.S. and Voelker, T.A. (unpublished data).Google Scholar
  53. 53.
    Töpfer, R., Martini, N. and Schell, J. (1995) Science 268, 681–686.PubMedCrossRefGoogle Scholar
  54. 54.
    Dehesh, K., Edwards, P., Hayes, T., Cranmer, A.M. and Fillatti, J. (1995) Plant Physiol. 109 (in press).Google Scholar
  55. 55.
    Davies, H.M. (1993) Phytochemistry 33, 1353–1356.CrossRefGoogle Scholar
  56. 56.
    James, D.W.J, and Dooner, H.K. (1990) Theoret. Appl. Genet. 80, 241–245.CrossRefGoogle Scholar
  57. 57.
    Sambanthamurti, R. and Oo, K.-C. (1990) in Seed Storage Compounds (Quinn, P.J. and Harwood, J.L., eds.), pp. 166–168, Portland Press, London.Google Scholar
  58. 58.
    Cronan, J.E. and Rock, C.O. (1987) in Escherichia coli and Salmonella typhimurium: Cellular and Molecular Biology (Neidhardt, F.C., Ingraham, J.L., Low, K.B., Magasanik, B., Schaechter, M. and Umbarger, H.E., eds.), Vol. 1, pp. 474–497, Amer. Soc. Mol. Biol., Washington, D.C.Google Scholar
  59. 59.
    Ohlrogge, J., Savage, L., Jaworski, J., Voelker, T. and Post-Beittenmiller, D. (1995) Arch. Biochem. Biophys. 317, 185–190.PubMedCrossRefGoogle Scholar
  60. 60.
    Voelker, T.A., Hayes, T.R., Cranmer, A.C., Turner, J.C. and Davies, H.M. Plant J. (in press).Google Scholar
  61. 61.
    Bafor, M., Stobart, A.K. and Stymne, S. (1990) J. Amer. Oil Chem. Soc. 67, 217–225.CrossRefGoogle Scholar
  62. 62.
    Oo, K.-C. and Huang, A.H.C. (1989) Plant Physiol. 91, 1288–1295.PubMedCrossRefGoogle Scholar
  63. 63.
    Eccleston, V., Voelker, T.A. and Ohlrogge, J. (1995) Planta 197 (in press).Google Scholar
  64. 64.
    Ohlrogge, J.B. (personal communication).Google Scholar
  65. 65.
    Ohlrogge, J.B., Jaworski, J.G. and Post-Beittenmiller, D. (1993) in Lipid Metabolism in Plants (T.S. Moore, Jr., ed.), pp. 3–32, CRC Press, Baton Rouge, LA.Google Scholar
  66. 66.
    Deerberg, S., Twickel, J.v., Förster, H.-H., Cole, T., Fuhrmann, J. and Heise, K.-P. (1990) Planta 180, 440–444.CrossRefGoogle Scholar
  67. 67.
    Heise, K.-P. and Fuhrmann, J. (1994) Prog. Lipid Res. 33, 87–95.PubMedCrossRefGoogle Scholar
  68. 68.
    Schuch, R., Brummel, M. and Spener, F. (1993) International workshop “Biotechnological Aspects of Plant Lipids”, May 26–29, 1993, Carmona, Spain, p. 31.Google Scholar
  69. 69.
    Singh, S.S., Nee, T.Y. and Pollard, M.R. (1986) Lipids 21, 143–149.CrossRefGoogle Scholar
  70. 70.
    Dehesh, K., Hawkins, D.J., Knutzon, D.S., Kridl, J.S. and Yuan, L. (personal communication).Google Scholar
  71. 71.
    Newman, T., Bruijn, F.J.d., Green, P., Kende, H., Mcintosh, L., Ohlrogge, J., Raikhel, N., Somerville, S., Thomashow, M., Retzel, E. and Somerville, C. (1994) Plant Physiol. 106, 1241–1255.PubMedCrossRefGoogle Scholar
  72. 72.
    Sasaki, T., Song, J.Y., Kogaban, Y., Matsui, E., Fang, F., Higo, H., Nagasaki, H., Hori, M., Miya, M., Murayamakayano, E., Takiguchi, T., Takasuga, A., Niki, T., Ishimaru, K., Ikeda, H., Yamamoto, Y., Mukai, Y., Ohta, I., Miyadera, N., Havukkala, I. and Minobe, Y. (1994) Plant J. 6, 615–624.PubMedCrossRefGoogle Scholar
  73. 73.
    Lawson, D.M., Derewenda, U., Serre, L., Ferri, S., Szittner, R., Wei, Y., Meighen, E.A. and Derewenda, Z.S. (1994) Biochemistry 33, 9382–9388.PubMedCrossRefGoogle Scholar
  74. 74.
    Davies, H.M., Hawkins, D.J. and Nelsen, J.S. (1995) Phytochemistry 39, 989–996.CrossRefGoogle Scholar
  75. 75.
    Yuan, L., Voelker, T.A. and Hawkins, D.J. (1995) Proc. Nat. Acad. Sci. U.S.A. 92, 10639–10643.CrossRefGoogle Scholar
  76. 76.
    Sloane, D.L., Leung, R., Craik, C.S. and Sigal, E. (1991) Nature 354, 149–152.PubMedCrossRefGoogle Scholar
  77. 77.
    Griffiths, G., Walsh, M.C. and Harwood, J.L. (1993) Phytochemistry 32, 1403–1405.CrossRefGoogle Scholar
  78. 78.
    Liu, D. and Post-Beittenmiller, D. (1995) J. Biol. Chem. 270, 16962–16969.PubMedCrossRefGoogle Scholar
  79. 79.
    Yuan, L., Hawkins, D. and Kridl, J. (personal communication).Google Scholar
  80. 80.
    Knutzon, D.S., Thompson, G.A., Radke, S.E., Johnson, W.B., Knauf, V.C. and Kridl, J.C. (1992) Proc. Nat. Acad. Sci. U.S.A. 89, 2624–2628.CrossRefGoogle Scholar
  81. 81.
    Dörmann, P., Spener, F. and Ohlrogge, J.B. (1993) Planta 189, 425–432.CrossRefGoogle Scholar
  82. 82.
    Leonard, J.M., Slabaugh, M.B. and Knapp, S.J. (unpublished data).Google Scholar
  83. 83.
    Walker, K.A. and Harwood, J.L. (1985) Biochem. J. 226, 551–556.PubMedGoogle Scholar
  84. 84.
    Rathinasabapathi, B., McCue, K.F., Gage, D.A. and Hanson, A.D. (1994) Planta 193, 155–162.PubMedCrossRefGoogle Scholar
  85. 85.
    Nishida, I., Imai, H., Ishizaki-Nishizawa, O., Tasaka, Y., Shirashi, H., Higashi, S., Hayashi, H., Beppu, T., Matsuo, T. and Murata, N. (1993) in Biochemistry and Molecular Biology of Membrane and Storage Lipids of Plants (Murata, N. and Somerville, C., eds.), pp. 79–88, The Society of American Plant Physiologists, Rockville, MD.Google Scholar
  86. 86.
    Wada, H., Gombos, Z., Sakamoto, T., Higashi, S., Los, D.A., Heinz, E., Schmidt, H., Nishida, I. and Murata, N. (1993) in Biochemistry and Molecular Biology of Membrane and Storage Lipids in Plants (Murata, N. and Somerville, C., eds.), pp. 67–78, The American Society of Plant Physiologists, Rockville, MD.Google Scholar
  87. 87.
    Voelker, T.A., Davies, M.H. and Knutzon, D.S. (1994) International Patent Application No. WO-94–10288. Published May 11, 1994.Google Scholar
  88. 88.
    Slabaugh, M., Leonard, J., Huestis, G., Crane, J. and Knapp, S. (1995) in Plant Lipid Metabolism (Kader, J.-C. and Mazliak, P., eds.), Kluwer Academic Publishers, Netherlands.Google Scholar
  89. 89.
    Hawkins, D. and Kridl, J. (personal communication).Google Scholar
  90. 90.
    Claros, M.G. and Heijne, G.v. (1994) Comput. Appl. Biosci. 10, 685–686.PubMedGoogle Scholar
  91. 91.
    Swofford, D.L. (1991) Version 3.0, Distributed by the Illinois Natural History Survey, Champaign, IL.Google Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Toni Voelker
    • 1
  1. 1.Calgene, Inc.DavisUSA

Personalised recommendations