Immune Response to Retroviral Infection

  • Stephen Norley
  • Reinhard Kurth
Part of the The Viruses book series (VIRS)


Since their discovery, retroviruses have been shown to be responsible for diseases in a wide range of hosts, from birds to humans. Indeed, the fact that most vertebrates contain within their genomes numerous (mostly noninfectious) retroviral sequences indicates just how long these viruses have maintained their intimate relationship with their host species as they evolved together (see Chapter 9; Temin, 1992). The recent appearance and relentless spread of the AIDS virus perhaps gives the impression that the host is helpless against retroviral infection. However, as with all infections with a foreign agent, the infected host will usually respond to active retroviral replication with the generation of a virus-specific immune response. This reaction is able in most cases, if not to eliminate the virus, then to suppress its replication to a harmless level. Identifying these protective mechanisms is therefore obviously of crucial importance in the design and production of prophylactic vaccines and immunotherapeutics.


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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Stephen Norley
    • 1
  • Reinhard Kurth
    • 1
  1. 1.Paul-Ehrlich-InstituteLangenGermany

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