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Aspergillus nidulans

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Abstract

Aspergillus nidulans is a sexually reproducing member of the Aspergillaceae (Raper and Fennell, 1965). The history of genetic investigations of this mold dates from 1945, when Pontecorvo started to look for an organism suitable for a genetic approach to “certain problems of the spacial organisation of the cell” (Pontecorvo et al., 1953). These problems amounted to an attempt to define the gene and its relation to cell me-tabolism. The reasons for the choice of A. nidulans as well as the story of the early development of genetical studies are fully given in Pontecorvo et al. (1953). Briefly, the advantages of this fungus include the fact that it is a haploid eukaryote which rapidly forms colonies on simple media and can therefore be treated as a microorganism. The asexual spores (conidia) are uninucleate and of a striking green color which is modified in a variety of spore-color mutants (see Table 1) to give conspicuous markers which are invaluable in genetic manipulations. The fungus is homothallic, so any strain can be crossed to any other, and, furthermore, stocks such as those built up in Glasgow can be assumed to be relatively isogenic since they are derived from a single wild isolate.

Keywords

  • Linkage Group
  • Nitrate Reductase
  • Aspergillus Nidulans
  • Nitrogen Mustard
  • Xanthine Dehydrogenase

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Clutterbuck, A.J. (1974). Aspergillus nidulans. In: King, R.C. (eds) Bacteria, Bacteriophages, and Fungi. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1710-2_26

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