Abstract
The genetic message is translated sequentially, three bases at time, starting from a defined AUG codon at the begining a cistron (Crick et al., 1961; Terzaghi et al., 1966). Deletions or additions of bases cause a shift in the reading frame of the genetic message and, therefore, such changes are called frame-shift mutations.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literature Cited
Crick, F. H. C., L. Barnett, S. Brenner, and R. J. Watts-Tobin, 1961 General nature of the genetic code for proteins. Nature (Lond.) 192:1227–1232.
Imada, M, M. Inouye, M. Eda and A. Tsugita, 1970 Frame-shift mutation in the lysozyme gene of bacteriophage T4: Demonstration of the insertion of four bases and the preferential occurrence of base addition in acridine mutagenesis. J. Mol. Biol. 54:199–217.
Inouye, M., E. Akaboshi, M. Kuroda and A. Tsugita, 1970a Replacement of all tryptophan residues in T4 bacteriophage lysozyme by tyrosine residues. J. Mol. Biol. 50:71–81.
Inouye, M., M. Imada and A. Tsugita, 1970b The amino acid sequence of T4 phage lysozyme. IV. Dilute acid hydrolysis and the order of tryptic peptides. J. Biol. Chem. 245:3479–3484.
Inouye, M., E. Akaboshi, A. Tsugita, G. Streisinger and Y. Okada, 1971 A frame-shift mutation resulting in the deletion of two base pairs in the lysozyme gene of bacteriophage T4. J. Mol. Biol. 30:39–47.
Lorena, M. J., M. Inouye and A. Tsugita, 1968 Studies on the lysozyme from the bacteriophage T4 eJD7eJD4, carrying two frame-shift mutations. Mol. Gen. Genet. 102:69–78.
Ocada, Y., S. Amagase and A. Tsugita, 1970 Frame-shift mutation in the lysozyme gene of bacteriophage T4: Demonstration of the insertion of five bases, and a summary of in vivo codons and lysozyme activities. J. Mol. Biol. 54:219–246.
Okada, Y., E. Terzaghi, G. Streisinger, J. Emrich, M. Inouye and A. Tsugita, 1966 A frame-shift mutation involving the addition of two base pairs in the lysozyme gene of phage T4. Proc. Natl. Acad. Sci. USA 56:1692–1698.
Okada, Y., G. Streisinger, J. Emrich, A. Tsugita and M. Inouye, 1968 Frame-shift mutations near the beginning of the lysozyme gene of bacteriophage T4. Science (Wash., D.C.) 162:807–808.
Okada, Y., G. Streisinger, J. Emrich, A. Tsugita and M. Inouye, 1969 The lysozyme of a triple frame-shift mutant strain of bacteriophage T4. J. Mol. Biol. 40:299–304.
Okada, Y., G. Streisinger, J. Emrich, J. Newton, A. Tsugita and M. Inouye 1972 The molecular basis of a mutational hot spot in the lysozyme gene of bacteriophage T4. Nature (Lond.) 236:341–388.
Owen, E. J., 1971 Some genetic studies of bacteriophage T4. Ph.D. Thesis, University of Oregon, Eugene, Oregon.
Streisinger, G., Y. Okada, J. Emrich, J. Newton, A. Tsugita, E. Terzaghi and M. Inouye, 1966 Frame-shift mutations and the genetic code. Cold Spring Harbor Symp. Quant. Biol. 31:77–84.
Terzaghi, E., Y. Okada, G. Streisinger, J. Emrich, M. Inouye and A. Tsugita, 1966 Change of a sequence of amino acids in phage T4 lysozyme by acridine-induced mutations. Proc. Natl. Acad. Sci. USA 56:500–507.
Tsugita, A., M. Inouye, E. Terzaghi and G. Streisinger, 1968 Purification of bacteriophage T4 lysozyme. J. Biol. Chem. 243:391.
Tsugita, A., M. Inouye, T. Imagawa, T. Nakanishi, Y. Okada, J. Emrich and G. Streisinger, 1969 Frame-shift mutations resulting in the changes of the same amino acid residue (140) in T4 bacteriophage lysozyme and in vivo codons for Trp, Tyr, Met, Val and Ile. J. Mol. Biol. 41:349–364.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1974 Springer Science+Business Media New York
About this chapter
Cite this chapter
Okada, Y. (1974). The Lysozyme Cistron of T4 Phage. In: King, R.C. (eds) Bacteria, Bacteriophages, and Fungi. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1710-2_22
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1710-2_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1712-6
Online ISBN: 978-1-4899-1710-2
eBook Packages: Springer Book Archive