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The Etiology and Neuropathology of Alcoholic Korsakoff’s Syndrome

Some Evidence for the Role of the Basal Forebrain

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Recent Developments in Alcoholism

Part of the book series: Recent Developments in Alcoholism ((RDIA,volume 5))

Abstract

Recent neuropsychological and neuropathological investigations with long-term alcoholics suggest that the etiology and neuropathology of the Wernicke-Korsakoff syndrome are more complex than previously believed. Although problem-solving and visuoperceptual deficits seem to develop slowly during decades of alcoholism, the amnesic symptoms associated with Korsakoff’s syndrome may appear acutely when severe malnutrition and alcoholism are combined. Furthermore, the report that alcoholic Korsakoff patients, like patients with Alzheimer’s disease, have endured a substantial neuronal loss in structures comprising the basal forebrain suggests a role for this brain region in the alcoholic patients’ amnesic syndrome. Some initial demonstrations of similarities in the memory disorders of alcoholic Korsakoff and Alzheimer patients indicate that Korsakoff’s syndrome may be accurately characterized as a “basal forebrain” as well as a “diencephalic” amnesia.

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Authors and Affiliations

  1. Psychology Service, San Diego Veterans Administration Medical Center, and Neuroscience Department, University of California School of Medicine at San Diego, San Diego, California, 92161, USA

    David P. Salmon

  2. Psychology Service, San Diego Veterans Administration Medical Center, and Psychiatry Department, University of California School of Medicine at San Diego, San Diego, California, 92161, USA

    Nelson Butters

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  1. David P. Salmon
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  1. Albert Einstein College of Medicine, Bronx, New York, USA

    Marc Galanter

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Salmon, D.P., Butters, N. (1987). The Etiology and Neuropathology of Alcoholic Korsakoff’s Syndrome. In: Galanter, M. (eds) Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1684-6_2

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