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Current Molecular Approaches to Experimental Thyroid Autoimmunity

  • Chapter
Immunological Aspects

Part of the book series: Subcellular Biochemistry ((SCBI,volume 12))

Abstract

Autoimmune thyroiditis is characterized by mononuclear cell infiltration of the thyroid gland, with accompanying tissue damage, and associated cellular and humoral autoimmunity to thyroid antigens such as thyroglobulin (Tg) and microsomal antigen (for reviews see Bigazzi and Rose, 1985; Rose et al., 1981; Weetman and McGregor, 1984; Weigle, 1980; Wick et al., 1985). Since the seminal studies by Rose and Witebsky (1956) demonstrating the experimental induction of autoimmune thyroiditis, animal models have been used extensively, both in the search for clues to the etiology of human autoimmune thyroiditis and to investigate basic mechanisms in the regulation of autoimmunity. Thyroid autoimmunity arises spontaneously in a number of species (Bigazzi and Rose, 1975), but most work has concentrated on the obese strain chicken (Wick et al., 1982, 1985), buffalo rats (Bigazzi and Rose, 1975), and the diabetes-prone BB/W rat (Sternthal et al., 1981). Thyroiditis may also be induced experimentally in many species by injecting Tg and an appropriate adjuvant (Weigle, 1980). A different model of thyroiditis can be induced in rats by a combination of thymectomy and irradiation (Penhaie et al., 1973, 1975). Studies of these various models have provided valuable information regarding the mechanisms involved in thyroid autoimmunity. More recently, we and others have begun to use a variety of in vitro techniques to gain insight into the molecular basis of thyroid autoimmunity.

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References

  • Abbas, A. K., Haber, S., and Rock, K. L., 1985, Antigen presentation by hapten-specific B lymphocytes. II. Specificity and properties of antigen-presenting B lymphocytes, and function of immunoglobulin receptors. J. Immunol. 135: 1661–1667.

    PubMed  CAS  Google Scholar 

  • Allen, E. M., Appel, M. C., and Braverman, L. E., 1986, The effect of iodide ingestion on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone BB/W rat. Endocrinology 118: 1977–1981.

    Article  PubMed  CAS  Google Scholar 

  • Bagchi, N., Brown, T. R., Urdanivia, E., and Sundick, R. S., 1985, Induction of autoimmune thyroiditis in chickens by dietary iodine. Science 230: 325–327.

    Article  PubMed  CAS  Google Scholar 

  • Banga, J. P., Pryce, G., Hammond, L., and Roitt, I. M., 1985, Structural features of the autoantigens involved in thyroid autoimmune disease: Thyroid microsomal/microvillar antigen. Mol. Immunol. 22: 629–642.

    Article  PubMed  CAS  Google Scholar 

  • Beienvaltes, W. H., 1969, Iodine and lymphocytic thyroiditis. Bull. All. India Med. Sci. 3: 145–146.

    Google Scholar 

  • Benjamin, D. C., Berzofsky, J. A., East, I. J., Gurd, F. R. N., Hannum, C., Leach, S. J., Margoliash, E., Michael, J. G., Miller, A., Prager, E. M., Reichlin, M., Sercarz, E. E., Smith-Gill, S. J., Todd, P. E., and Wilson, A. C., 1984, The antigenic structure of proteins: A reappraisal. Annu. Rev. Immunol. 2: 67–101.

    Article  PubMed  CAS  Google Scholar 

  • Bigazzi, P. E., and Rose, N. R., 1975, Spontaneous autoimmune thyroiditis in animals as a model of human disease. Prog. Allergy 19: 245–274.

    PubMed  CAS  Google Scholar 

  • Bigazzi, P. E., and Rose, N. R., 1985, Autoimmune thyroid disease. In The Autoimmune Diseases (Bigazzi, P. E., and Rose, N. R., eds.), pp. 161–198, Academic Press, Orlando.

    Google Scholar 

  • Bottazzo, G. F., Pujol-Borrel, R., Hanafusa, T., and Feldmann, M., 1983, Role of aberrant HLA-DR expression and antigen presentation in induction of endocrine autoimmunity. Lancet 2: 1115–1118.

    Article  PubMed  CAS  Google Scholar 

  • Braley-Mullen, H., Thompson, J. G., Sharp, G. C., and Kyriakos, M., 1981, Adoptive transfer of experimental autoimmune thyroiditis (EAT) with in vitro activated lymph node cells from thyroglobulin sensitized guinea-pigs: Characterization of the cell that transfers EAT. J. Immunol. 127: 1767–1771.

    PubMed  CAS  Google Scholar 

  • Braley-Mullen, H., Thompson, J. G., Sharp, G. C., and Kyriakos, M., 1983, Adoptive transfer of experimental autoimmune thyroiditis (EAT) in guinea-pigs: Requirement for la-positive antigen-presenting cells for in vitro activation of effector T cells. Cell. Immunol. 81: 243–252.

    Article  PubMed  CAS  Google Scholar 

  • Braley-Mullen, H., Johnson, M., Sharp, G. C., and Kyriakos, M., 1985, Induction of experimental autoimmune thyroiditis in mice with in vitro activated splenic T cells. Cell. Immunol. 93: 132–143.

    Article  PubMed  CAS  Google Scholar 

  • Brown, T. R., Bagchi, N., and Sundick, R. S., 1985, Analysis of tri-iodothyronine and thyroxine-binding autoantibodies in chickens susceptible to autoimmune thyroiditis. J. Immunol. 134: 3845–3848.

    PubMed  CAS  Google Scholar 

  • Champion, B. R., Varey, A.-M., Katz, D., Cooke, A., and Roitt, I. M., 1985, Autoreactive T cell lines specific for mouse thyroglobulin. Immunology 54: 513–519.

    PubMed  CAS  Google Scholar 

  • Champion, B. R., Hutchings, P., Davies, S., Marshall-Clarke, S., Cooke, A., and Roitt, I. M., 1986a, Helper and suppressor activities of an autoreactive mouse thyroglobulin-specific T cell clone. Immunology 58: 51–56.

    PubMed  CAS  Google Scholar 

  • Champion, B., Hutchings, P., Rayner, D., Marshall-Clarke, S., Roitt, I. M., and Cooke, A., 1986b, Autoantigenicity of murine thyroglobulin. J. Endocrinol. Invest. 9(Suppl.3): 77.

    Google Scholar 

  • Charreire, J., and Michel-Bechet, M., 1982, Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells. III. Induction of thyroiditis by thyroid-sensitized T lymphoblasts. Eur. J. Immunol. 12: 420–425.

    Google Scholar 

  • Charreire, J., and Salamero, J., 1984, Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells. VI. Evaluation of its frequency using limiting dilution analysis. Tissue Antigens 23: 72–80.

    Article  PubMed  CAS  Google Scholar 

  • Cooke, A., 1986, Idiotypes, anti-idiotypes and autoimmune disease. Plasma Ther. Transfus. Technol. 7: 161–170.

    CAS  Google Scholar 

  • Creemers, P., Rose, N. R., and Kong, Y. M., 1983, Experimental autoimmune thyroiditis. In vitro cytotoxic effects of T lymphocytes on thyroid monolayers. J. Exp. Med. 157: 559–571.

    Article  PubMed  CAS  Google Scholar 

  • Czarnocka, B., Ruf, J., Ferrand, M., Carrayon, P., and Lissitzky, S., 1985, Purification of the human thyroid peroxidase and its identification as the microsomal antigen involved in autoimmune thyroid diseases. FEBS Lett. 190: 147–152.

    Article  PubMed  CAS  Google Scholar 

  • Czarnocka, B., Ruf, J., Ferrand, M., Lissitzky, S., and Carrayon, P., 1986, Evidence that thyroid peroxidase is the “microsomal” antigen. In The Thyroid and Autoimmunity (Czarnocka, B., Ruf, J., Ferrand, M., Lissitzky, S., and Carrayon, P., eds.), pp. 84–85, Elsevier, Amsterdam.

    Google Scholar 

  • Di Lauro, R., Obici, S., Condliffe, D., Ursini, V. M., Musti, A., Moscatelli, C., and Avvedimento, V. E., 1985, The sequence of 967 amino acids at the carboxyl-end of rat thyroglobulin. Location and surroundings of two thyroxine-forming sites. Eur. J. Biochem. 148: 7–11.

    Article  PubMed  Google Scholar 

  • Dinsart, C., Libert, F., Ruel, J., Ludgate, M., Pommier, J., Dussault, J., and Vassart, G., 1986, Molecular cloning of a thyroid peroxidase cDNA fragment encoding epitopes involved in Hashimotos thyroiditis (HT). J. Endocrinol. Invest. 9(Suppl.3): 90.

    Google Scholar 

  • Formisano, S., Moscatelli, C., Zarrilli, R., Di Ieso, B., Acquaviva, R., Obici, S., Palumbo, G., and Di Lauro, R., 1985, Prediction of the secondary structure of the carboxy-terminal third of rat thyroglobulin. Biochem. Biophys. Res. Commun. 133: 766–772.

    Article  PubMed  CAS  Google Scholar 

  • Golding, H., Munitz, T. I., and Singer, A., 1985, Characterization of antigen-specific la-restricted, L3T4+ cytolytic T lymphocytes and assessment of thymic influence on their self specificity. J. Exp. Med. 162: 943–961.

    Article  PubMed  CAS  Google Scholar 

  • Hanafusa, T., Pujol-Borrel, R., Chiovata, R., Russel, R. C. G., Doniach, D., and Bottazzo, G. F., 1983, Aberrant expression of HLA-DR antigen on thyrocytes in Graves’ disease: Relevance for autoimmunity. Lancet 2: 1111–1115.

    Article  PubMed  CAS  Google Scholar 

  • Harach, H. R., Escalante, D. A., Onativia, A., Outes, J. L., Day, E. S., and Williams, E. D., 1985, Thyroid carcinoma and thyroiditis in an endemic goitre region before and after iodine prophylaxis. Acta Endocrinol.(Copenh.) 108: 55–60.

    CAS  Google Scholar 

  • Hutchings, P., Rayner, D. C., Champion, B. R., Marshall-Clarke, S., Macatonia, S., Roitt, I. M., and Cooke, A., 1987, High efficiency antigen presentation by thyroglobulin primed murine splenic B cells. Eur. J. Immunol. 17: 393–398.

    Article  PubMed  CAS  Google Scholar 

  • Kohno, Y., Nakajima, H., and Tarutani, O., 1985, Interspecies cross-reactive determinants of thyroglobulin recognized by autoantibodies. Clin. Exp. Immunol. 61: 44–48.

    PubMed  CAS  Google Scholar 

  • Kong, Y. M., Rose, N. R., Elrehewy, M., Michaels, R., Giraldo, A. A., Accavitti, M. A., and Leon, M. A., 1980, Thyroid alloantigens in autoimmunity. Transplant. Proc. 12: (Suppl. 1): 129–134.

    PubMed  CAS  Google Scholar 

  • Kong, Y.-C. M., Bagnasco, M., and Canonica, G. W., 1986a, How do T cells mediate autoimmune thyroiditis? Immunol. Today 7: 337–339.

    Article  Google Scholar 

  • Kong, Y. M., Giraldo, A. A., Justin, J. M., Simon, L. L., and Fuller, B. E., 1986b, Are conserved regions on thyroglobulin thyroiditogenic? In The Thyroid and Autoimmunity (Kong, Y. M., Giraldo, A. A., Justin, J. M., Simon, L. L., and Fuller, B. E., eds.), pp. 151–152, Elsevier, Amsterdam.

    Google Scholar 

  • Kotani, T., Maeda, M., Umeki, K., and Ohtaki, S., 1985a, Epitopic differences among rat thyroglobulins. Immunol. Lett. 9: 167–172.

    Article  PubMed  CAS  Google Scholar 

  • Kotani, T., Maeda, M., Ohtaki, S., Kobayashi, S., and Okuyama, H., 1985b, Analyses of the specificity of mouse monoclonal antibodies to syngeneic and allogeneic thyroglobulin. Clin. Immunol. Immunopathol. 34: 147–157.

    Article  PubMed  CAS  Google Scholar 

  • Lanzavecchia, A., 1985, Antigen-specific interaction between T and B cells. Nature 314: 537–538.

    Article  PubMed  CAS  Google Scholar 

  • Londei, M., Lamb, J. R., Bottazzo, G. F., and Feldmann, M., 1984, Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. Nature 312: 639–641.

    Article  PubMed  CAS  Google Scholar 

  • Lukacher, A. E., Morrison, L. A., Braciale, V. L., Malissen, B., and Braciale, T. J., 1985, Expression of specific cytolytic activity by H-2I region restricted, influenza virus-specific T lymphocyte clones. J. Exp. Med. 162: 171–187.

    Article  PubMed  CAS  Google Scholar 

  • Male, D., Pryce, G., Quartey-Papafio, R., and Roitt, I. M., 1983, The occurrence of defined idiotypes on autoantibodies to mouse thyroglobulin. Eur. J. Immunol. 13: 942–947.

    Article  PubMed  CAS  Google Scholar 

  • Male, D. K., Champion, B. R., Pryce, G., Matthews, H., and Shepherd, P., 1985a, Antigenic determinants on human thyroglobulin differentiated using antigen fragments. Immunology 54: 419–427.

    PubMed  CAS  Google Scholar 

  • Male, D., Pryce, G., and Roitt, I. M., 1985b, Molecular analysis of induced idiotypes associated with autoanti-thyroglobulin. Mol. Immunol. 22: 255–263.

    Article  PubMed  CAS  Google Scholar 

  • Male, D., Pryce, G., Cooke, A., Hutchings, P., Marshall-Clarke, S., and Roitt, I. M., 1986, T and B cell connections in experimentally induced autoimmunity. Ann. N.Y. Acad. Sci. 475: 94–105.

    Article  PubMed  CAS  Google Scholar 

  • Malthiery, Y., and Lissitzky, S., 1985, Sequence of the 5′-end quarter of the human thyroglobulin messenger ribonucleic acid and of its deduced amino-acid sequence. Eur. J. Biochem. 147: 53–58.

    Article  PubMed  CAS  Google Scholar 

  • Mangkornkanok, M., Marcowitz, A. S., and Battifora, H. A., 1972, Chronic thyroiditis in the rabbit induced with homologous thyroid microsomes. Science 178: 316–318.

    Article  PubMed  CAS  Google Scholar 

  • Maron, R., Zerubavel, R., Friedman, A., and Cohen, I. R., 1983, T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice. J. Immunol. 131: 2316–2322.

    PubMed  CAS  Google Scholar 

  • Mariotti, S., Bechi, R., Anelli, S., Ruf, J., Lombardi, A., Chiovata, L., Czarnocka, B., Carayon, P., and Pinchera, A., 1986, Evidence for identity of serum thyroid microsomal and anti-human thyroid peroxidase autoantibodies. In The Thyroid and Autoimmunity (Mariotti, S., Bechi, R., Anelli, S., Ruf, J., Lombardi, A., Chiovata, L., Czarnocka, B., Carayon, P., and Pinchera, A., eds.), pp. 86–87, Elsevier, Amsterdam.

    Google Scholar 

  • Marriq, C., Rolland, M., and Lissitzky, S., 1983, Amino acid sequence of the unique 3, 5, 5′-triiodothyronine-containing sequence from porcine thyroglobulin. Biochem. Biophys. Res. Commun. 112: 206–213.

    Article  PubMed  CAS  Google Scholar 

  • Marriq, C., Lejeune, P. J., Malthiery, Y., Rolland, M., and Lissitzky, S., 1984, Precursor-product relationship between the 26kDa and 18kDa fragments formed by iodination of human thyroglobulin. FEBS Lett. 175: 140–146.

    Article  PubMed  CAS  Google Scholar 

  • Matsuyama, T., Fukumori, J., and Tanaka, H., 1983, Evidence of unique idiotypic determinants and similar idiotypic determinants on human anti-thyroglobulin antibodies. Clin. Exp. Immunol. 51: 381–386.

    PubMed  CAS  Google Scholar 

  • Mercken, L., Simons, M.-J., Swillens, S., Massaer, M., and Vassart, G., 1985, Primary structure of bovine thyroglobulin deduced from the sequence of its 8431-base complementary DNA. Nature 316: 647–651.

    Article  PubMed  CAS  Google Scholar 

  • Morrison, L. A., Lukacher, A. E., Braciale, V. L., Fan, D. P., and Braciale, T. J., 1986, Differences in antigen presentation to MHC class I- and class II-restricted influenza virus-specific cytolytic T lymphocyte clones. J. Exp. Med. 163: 903–921.

    Article  PubMed  CAS  Google Scholar 

  • Musti, A. M., Avvedimento, E. V., Polistina, C., Ursini, V. M., Obici, S., Nitsch, L., Cocozza, S., and Di Lauro, R., 1986, The complete structure of the rat thyroglobulin gene. Proc. Natl. Acad. Sci. U.S.A. 83: 323–327.

    Article  PubMed  CAS  Google Scholar 

  • Nye, L., Pontes de Carvalho, L. C., and Roitt, I. M., 1980, Restrictions in the response to autologous thyroglobulin in the human. Clin. Exp. Immunol. 41: 252–263.

    PubMed  CAS  Google Scholar 

  • Okayasu, I., 1985, Transfer of experimental autoimmune thyroiditis to normal syngeneic mice by injection of mouse thyroglobulin-sensitized T lymphocytes after activation with concanavilin A. Clin. Immunol. Immunopathol. 36: 101–109.

    Article  PubMed  CAS  Google Scholar 

  • Pearce, C. J., Byfield, G. H., Edmonds, C. J., Lalloz, M. R. A., and Himsworth, R. L., 1981, Autoantibodies to thyroglobulin cross-reacting with iodothyronines. Clin. Endocrinol. 15: 1–10.

    Article  CAS  Google Scholar 

  • Penhale, W. J., Farmer, A., McKenna, R. P., and Irvine, W. J., 1973, Spontaneous thyroiditis in thymectomized and irradiated Wistar rats. Clin. Exp. Immunol. 15: 225–236.

    PubMed  CAS  Google Scholar 

  • Penhale, W. J., Farmer, A., and Irvine, W. J., 1975, Thyroiditis in T-cell depleted rats. Influence of strain, radiation dose, adjuvants and anti-lymphocyte serum. Clin. Exp. Immunol. 21: 362–375.

    PubMed  CAS  Google Scholar 

  • Portmann, L., Hamada, N., Heinrich, G., and De Groot, L. J., 1985, Anti-thyroid peroxidase antibody in patients with autoimmune thyroid disease: Possible identity with anti-microsomal antibody. J. Clin. Endocrinol. Metab. 61: 1001–1003.

    Article  PubMed  CAS  Google Scholar 

  • Rawitch, A. B., Chernoff, S. B., Litwer, M. R., Rouse, J. B., and Hamilton, J. W., 1983, Thyroglobulin structure-function. The amino acid sequence surrounding thyroxine. J. Biol. Chem. 258: 2079–2082.

    PubMed  CAS  Google Scholar 

  • Rayner, D. C., Delves, P. J., Warren, D., Roitt, I. M., and Champion, B. R., 1987, T cell hybridomas specific for self and foreign thyroglobulins. Immunology 60: 231–237.

    PubMed  CAS  Google Scholar 

  • Rock, K. L., Benacerraf, B., and Abbas, A. K., 1984, Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J. Exp. Med. 160: 1102–1113.

    Article  PubMed  CAS  Google Scholar 

  • Roitt, I. M., Campbell, P. N., and Doniach, D., 1958, The nature of the thyroid autoantibodies present in patients with Hashimoto’s thyroiditis (lymphadenoid goitre). Biochem. J. 69: 248–257.

    PubMed  CAS  Google Scholar 

  • Romball, C. G., and Weigle, W. O., 1984, T cell competence to heterologous and homologous thyroglobulins during the induction of experimental autoimmune thyroiditis. Eur. J. Immunol. 10: 887–893.

    Article  Google Scholar 

  • Rose, N. R., and Witebsky, E., 1956, Studies on organ specificity. V. Changes in the thyroid glands of rabbits following active immunization with rabbit thyroid extracts. J. Immunol. 76: 417–427.

    PubMed  CAS  Google Scholar 

  • Rose, N. R., Kong, Y. M., Okayasu, I., Giraldo, A. A., Beisel, K., and Sundick, R. S., 1981, T-cell regulation in autoimmune thyroiditis. Immunol. Rev. 55: 299–314.

    Article  PubMed  CAS  Google Scholar 

  • Rose, N. R., Accavitti, M., Pydyn, E. F., Leon, M. A., and Brown, R. K., 1982, The use of hybridoma antibodies to probe the antigenic determinants of thyroglobulin. Adv. Exp. Med. Biol. 150: 23–35.

    Article  PubMed  CAS  Google Scholar 

  • Salamero, J., and Charreire, J., 1983, Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells. V. The primary syngeneic sensitization is under I-A subregion control. Eur. J. Immunol. 13: 948–951.

    Article  PubMed  CAS  Google Scholar 

  • Salamero, J., and Charreire, J., 1985, Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells (TEC). VII. Generation of thyroid specific cytotoxic effector cells. Cell. Immunol. 91: 111–118.

    Article  PubMed  CAS  Google Scholar 

  • Salamero, J., Michel-Bechet, M., Wietzerbin, J., and Charreire, J., 1985, Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells (TEC). VIII. γ-Interferon induced Ia antigen expression on TEC cultures. Tissue Antigens 25: 266–277.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, R. H., 1985, T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu. Rev. Immunol. 3: 237–261.

    Article  PubMed  CAS  Google Scholar 

  • Shimojo, N., Kohno, Y., Tarutani, O., Sasaki, N., and Nakajima, H., 1986, Antigenic determinants on thyroglobulin recognized by T cells in patients with chronic thyroiditis. Acta Endocrinol. 111: 481–486.

    PubMed  CAS  Google Scholar 

  • Shimonkevitz, R., Kappler, J., Marrack, P., and Grey, H., 1983, Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J. Exp. Med. 158: 303–316.

    Article  PubMed  CAS  Google Scholar 

  • Simon, L. L., Krco, C. J., David, C. S., and Kong, Y. M., 1985, Characterization of the in vitro T cell proliferative response to murine and human thyroglobulins in thyroiditis-susceptible and -resistant mice. Cell. Immunol. 94: 243–253.

    Article  PubMed  CAS  Google Scholar 

  • Simon, L. L., Justen, J. M., Giraldo, A. A., Krco, C. J., and Kong, Y.-C. M., 1986, Activation of cytotoxic T cells and effector cells in experimental autoimmune thyroiditis by shared determinants of mouse and human thyroglobulins. Clin. Immunol. Immunopathol. 39: 345–356.

    Article  PubMed  CAS  Google Scholar 

  • Sternthal, E., Like, A. A., Sarantis, K., and Braverman, L. E., 1981, Lymphocytic thyroiditis and diabetes in the BB/W rat. A new model of autoimmune endocrinopathy. Diabetes 30: 1058–1061.

    Article  PubMed  CAS  Google Scholar 

  • Stylos, W. A., and Rose, N. R., 1977, Splitting of human thyroglobulin. VI. The antigenicity of the pepsin derived fragments. Clin. Exp. Immunol. 27: 245–253.

    PubMed  CAS  Google Scholar 

  • Sundick, R. S., Herdegen, D., Brown, T. R., and Bagchi, N., 1986, Thyroiditis induced by dietary iodine may be due to the increased immunogenicity of highly iodinated thyroglobulin. In The Thyroid and Autoimmunity (Sundick, R. S., Herdegen, D., Brown, T. R., and Bagchi, N., eds.), pp. 213–214, Elsevier, Amsterdam.

    Google Scholar 

  • Targovnik, H. M., Pohl, V., Christophe, D., Cabrer, B., Brocas, H., and Vassart, G., 1984, Structural organization of the 5′ region of the human thyroglobulin gene. Eur. J. Biochem. 141: 271–277.

    Article  PubMed  CAS  Google Scholar 

  • Tite, J. P., and Janeway, C. A., Jr., 1984, Cloned helper T cells can kill B lymphoma cells in the presence of specific antigen: Ia restriction and cognate vs. non-cognate interactions in cytolysis. Eur. J. Immunol. 14: 878–886.

    Article  PubMed  CAS  Google Scholar 

  • Todd, I., Pujol-Borrel, R., Hammond, L., Bottazzo, G. F., and Feldmann, M., 1985, Interferon-γ induces HLA-DR expression by thyroid epithelium. Clin. Exp. Immunol. 61: 265–273.

    PubMed  CAS  Google Scholar 

  • Tomazic, V., and Rose, N. R., 1976, Autoimmune thyroiditis. VIII. Role of different thyroid antigens in the induction of experimental autoimmune thyroiditis. Immunology 30: 63–68.

    PubMed  CAS  Google Scholar 

  • Van Herle, A. J., Vassart, G., and Dumont, J. E., 1979, Control of thyroglobulin synthesis and secretion. N. Engl. J. Med. 301: 239–249, 307–314.

    Article  PubMed  Google Scholar 

  • Vassart, G., Bacolla, A., Brocas, H., Christophe, D., De Martynoff, G., Leriche, A., Mercken, L., Parma, J., Pohl, V., and Targovnik, H., 1985, Structure, expression and regulation of the thyroglobulin gene. Mol. Cell. Endocrinol. 40: 89–97.

    Article  PubMed  CAS  Google Scholar 

  • Vladutiu, A. O., and Rose, N. R., 1972, Murine thyroiditis. III. Influence of syngeneic and allogeneic thyroid antigen on induction of the disease. Clin. Exp. Immunol. 11: 245–254.

    PubMed  CAS  Google Scholar 

  • Voorbij, H. A. M., Kabel, P. J., and Drexhage, H. A., 1986, Antigen presenting cells (APC’s) in the thyroid autoimmune response in the BB/W rat. In The Thyroid and Autoimmunity (Voorbij, H. A. M., Kabel, P. J., and Drexhage, H. A., eds.), pp. 166–169, Elsevier, Amsterdam.

    Google Scholar 

  • Weetman, A. P., and McGregor, A. M., 1984, Autoimmune thyroid disease: Developments in our understanding. Endocrine Rev. 5: 309–355.

    Article  CAS  Google Scholar 

  • Weetman, A. P., McGregor, A. M., and Hall, R., 1983, Thyroglobulin uptake and presentation by macrophages in experimental autoimmune thyroiditis. Immunology 50: 315–318.

    PubMed  CAS  Google Scholar 

  • Weigle, W. O., 1980, Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv. Immunol. 30: 159–273.

    Article  PubMed  CAS  Google Scholar 

  • Wick, G., Boyd, R., Hala, K., Thunold, S., and Kofier, H., 1982, Pathogenesis of spontaneous autoimmune thyroiditis in obese strain (OS) chickens. Clin. Exp. Immunol. 47: 1–18.

    PubMed  CAS  Google Scholar 

  • Wick, G., Most, J., Schauenstein, K., Kromer, K., Dietrich, H., Ziemiecki, A., Fassler, R., Schwarz, S., Neu, N., and Hala, K., 1985, Spontaneous autoimmune thyroiditis—a bird’s eye view. Immunol. Today 6: 359–364.

    Article  Google Scholar 

  • Yeni, P., and Charreire, J., 1981, Syngeneic sensitization of mouse lymphocytes on monolayers of thyroid epithelial cells. I. Study of proliferative responses. Cell. Immunol. 62: 313–323.

    Article  PubMed  CAS  Google Scholar 

  • Zanetti, M., Barton, R., and Bigazzi, P., 1983a, Anti-idiotypic immunity and autoimmunity. II. Idiotypic determinants of autoantibodies and lymphocytes in spontaneous and experimentally induced autoimmune thyroiditis. Cell. Immunol. 75: 292–301.

    Article  PubMed  CAS  Google Scholar 

  • Zanetti, M., De Baets, M., and Rogers, J., 1983b, High degree of idiotypic cross-reactivity among murine antibodies to thyroglobulin. J. Immunol. 131: 2452–2457.

    PubMed  CAS  Google Scholar 

  • Zanetti, M., Rogers, J., and Katz, D. H., 1984, Induction of autoantibodies to thyroglobulin by antiidiotypic antibodies. J. Immunol. 133: 240–243.

    PubMed  CAS  Google Scholar 

  • Zanetti, M., Liu, F. T., Rogers, J., and Katz, D. H., 1985, Heavy and light chains of the same idiotype. J. Immunol. 135: 1245–1251.

    PubMed  CAS  Google Scholar 

  • Zanetti, M., 1986, Idiotypic regulation of autoantibody production. CRC Crit. Rev. 6: 151–183.

    CAS  Google Scholar 

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  1. Brian R. Champion

    Present address: Immunobiology Department, Glaxo Group Research Ltd., Greenford, UB6 0HE, UK

Authors and Affiliations

  1. Department of Immunology, Middlesex Hospital Medical School, London, W1P 9PG, UK

    Brian R. Champion, Patricia Hutchings, Anne Cooke, Kevin Page, Gopa Biswas-Hughes & Humberto Assis de Paiva

  2. Institute of Psychiatry, Denmark Hill, London, SE5 1JK, UK

    David Male

  3. Department of Pathology, University of Manitoba, Winnipeg, Canada, R3G 0W3

    David C. Rayner

  4. Department of Endocrinology, MRC Clinical Research Centre, Harrow, HA1 3UJ, UK

    Peter Byfield

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  1. Brian R. Champion
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  2. Patricia Hutchings
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  3. Anne Cooke
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  4. Kevin Page
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  5. Gopa Biswas-Hughes
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  6. Humberto Assis de Paiva
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  7. David Male
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  8. David C. Rayner
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  9. Peter Byfield
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  1. North East Thames Regional Transfusion Centre, Brentwood, Essex, England

    J. R. Harris

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© 1988 Springer Science+Business Media New York

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Champion, B.R. et al. (1988). Current Molecular Approaches to Experimental Thyroid Autoimmunity. In: Harris, J.R. (eds) Immunological Aspects. Subcellular Biochemistry, vol 12. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1681-5_9

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  • DOI: https://doi.org/10.1007/978-1-4899-1681-5_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1683-9

  • Online ISBN: 978-1-4899-1681-5

  • eBook Packages: Springer Book Archive

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