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Use of Serotonin-Active Drugs in Alcohol Preference Studies

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Recent Developments in Alcoholism

Part of the book series: Recent Developments in Alcoholism ((RDIA,volume 7))

Abstract

Interest in finding a cure for alcoholism has sparked enthusiastic research into drugs that might accomplish this goal. Since decreases in brain serotonin had been shown to influence voluntary ethanol ingestion, numerous studies were conducted with the intent of establishing a basis on which a treatment for the alcoholic could be based. Along the path of discovery many inconsistencies have been encountered. After considerable research it became clear that the hope for an effective treatment resided not with impairment of but rather with enhancement of brain serotonergic function. One of the first effective therapeutic approaches has apparently emerged in the case of selective serotonin uptake inhibition. However, even with a wealth of information available, the mechanism by which an elevation of brain serotonergic function diminishes ethanol intake is unclear. The research conducted in this area has resulted not only in a potential therapeutic drug but also insight into the complexity of alcoholism as well. The intent of research reviewed here has been a better understanding of the role that brain serotonergic function may play in the regulation of ethanol ingestion.

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References

  1. Myers RD, Veale WL: Alcohol preference in the rat: Reduction following depletion of brain serotonin. Science 160: 1469–1471, 1968.

    Article  PubMed  CAS  Google Scholar 

  2. Myers RD, Melchior CL: Alcohol and alcoholism: Role of serotonin, in Essman WB (ed): Serotonin in Health and Disease, Vol. II, Physiological Regulation and Pharmacological Action. New York, Spectrum, 1977, p 373.

    Google Scholar 

  3. Hill SY: Intraventricular injection of 5-hydroxytryptamine and alcohol consumption in rats. Biol Psychiatry 8: 151–158, 1974.

    PubMed  CAS  Google Scholar 

  4. Myers RD, Evans JE, Yaksh TL: Ethanol preference in the rat: Interactions between brain serotonin and ethanol, acetaldehyde, paraldehyde, 5-HTP and 5-HTOL. Neuropharmacology 11: 539–549, 1972.

    Article  PubMed  CAS  Google Scholar 

  5. Geller I: Effects of para-chlorophenylalanine and 5-hydroxytryptophan on alcohol intake in the rat. Pharmacol Biochem Behav 1: 361–365, 1973.

    Article  PubMed  CAS  Google Scholar 

  6. Geller I, Purdy R, Merritt JH: Alterations in ethanol preference in the rat: The role of brain biogenic amines. Ann NY Acad Sci 215: 54–59, 1973.

    Article  PubMed  CAS  Google Scholar 

  7. Miksic SL, Barry H, Krimmer EC: Increased serotonin activity reduces alcohol preference. Alcoholism 6: 149–155, 1982.

    Google Scholar 

  8. Zabik JE, Liao S-S, Jeffreys M, et al: The effects of DL-5-hydroxytryptophan on ethanol consumption by rats. Res Commun Chem Pathol Pharmacol 20: 69–78, 1978.

    PubMed  CAS  Google Scholar 

  9. Zabik JE, Binkerd K, Roache JD: Serotonin and ethanol aversion in the rat, in Naranjo CA, Sellers EM (eds): Research Advances in New Psychopharmacological Treatments for Alcoholism, New York, Elsevier, 1985, p 87.

    Google Scholar 

  10. Zabik JE, Roache JD: 5-Hydroxytryptophan-induced conditioned taste aversion to ethanol in the rat. Pharmacol Biochem Behav 18: 785–790, 1983.

    Article  PubMed  CAS  Google Scholar 

  11. Geller I, Hartmann RJ, Messiha FS: Blockade of 5-HTP reduction of ethanol drinking with the decarboxylase inhibitor, Ro 4-4602. Pharmacol Biochem Behav 15: 871–874, 1981.

    Article  PubMed  CAS  Google Scholar 

  12. Pletscher A, Gey KF: The effect of a new decarboxylase inhibitor on endogenous and exogenous monoamines. Biochem Pharmacol 12: 223–228, 1963.

    Article  PubMed  CAS  Google Scholar 

  13. Bartholini G, Pletscher A: Effects of various decarboxylase inhibitors on the cerebral metabolism of dihydroxyphenylalanine. J Pharm Pharmacol 21: 323–324, 1969.

    Article  PubMed  CAS  Google Scholar 

  14. Ervin GN, Carter RB, Webster EL, et al: Evidence that taste aversion learning induced by 1-5-hydroxytryptophan is mediated peripherally. Pharmacol Biochem Behav 20: 799–802, 1984.

    Article  PubMed  CAS  Google Scholar 

  15. Mawson C, Whittington H: Evaluation of the peripheral and central antagonistic activities against 5-hydroxytryptamine of some new agents. Br J Pharmacol 39: 223, 1970.

    Google Scholar 

  16. Sprince H, Parker CM, Smith GG, et al: Alcoholism: Biochemical and nutritional aspects of brain amines, aldehydes, and amino acids. Nutr Rep Int 5: 185–200, 1972.

    CAS  Google Scholar 

  17. Myers RD, Melchior CL: Dietary tryptophan and the selection of ethyl alcohol in different strains of rats. Psychopharmacology 42: 109–115, 1975.

    Article  CAS  Google Scholar 

  18. Fuller RW, Snoddy HD, Perry W, et al: The effects of quipazine on serotonin metabolism in rat brain. Life Sci 18: 925–934, 1976.

    Article  PubMed  CAS  Google Scholar 

  19. Hong E, Sancilio LF, Vargas R, et al: Similarities between the pharmacological actions of quipazine and serotonin. Eur J Pharmacol 6: 274–280, 1969.

    Article  PubMed  CAS  Google Scholar 

  20. Lawrin MO, Naranjo CA, Sellers EM: Identification and testing of new drugs for modulating alcohol consumption. Psychopharmacol Bull 22: 1020–1025, 1986.

    CAS  Google Scholar 

  21. Fuller RW: Pharmacology of central serotonin neurons. Ann Rev Pharmacol Toxicol 20: 111–127, 1980.

    CAS  Google Scholar 

  22. Fuller RW: Selectivity among monoamine oxidase inhibitors and its possible importance for development of antidepressant drugs. Prog Neuropsychopharmacol 2: 303–311, 1978.

    Article  CAS  Google Scholar 

  23. Sanders AU, Collins AC, Wesley VH: Reduction of alcohol selection by pargyline in mice. Psychopharmacologia 46: 159–162, 1976.

    Article  PubMed  CAS  Google Scholar 

  24. Sanders B, Collins AC, Petersen DR, et al: Effects of three monoamine oxidase inhibitors on ethanol preference in mice. Pharmacol Biochem Behav 6: 319–324, 1977.

    Article  PubMed  CAS  Google Scholar 

  25. Dembiec D, MacNamee D, Cohen G: The effect of pargyline and other monoamine oxidase inhibitors on blood acetaldehyde levels in ethanol-intoxicated mice. J Pharmacol Exp Ther 197: 332–339, 1976.

    PubMed  CAS  Google Scholar 

  26. Opitz K: Effect of fenfluramine on alcohol and saccharin consumption in the rat. S Afr Med J 46: 742–744, 1972.

    PubMed  CAS  Google Scholar 

  27. Krasner N, Moore MR, Dow J, et al: Fenfluramine and 780SE in experimental alcoholism in rats. Postgrad Med J 51(Suppl 1): 76–79, 1975.

    PubMed  Google Scholar 

  28. Krasner N, Moore MR, Goldberg A, et al: A trial of fenfluramine in the treatment of the chronic alcoholic patient. Br J Psychiatry 128: 346–353, 1976.

    Article  PubMed  CAS  Google Scholar 

  29. Fuller RW, Perry KW, Snoddy H, et al: Comparison of the specificity of 3-(p-trifluoromethyl-phenoxy)-N-methyl-3-phenylpropylamine and chlorimipramine as amine uptake inhibitors in mice. Eur J Pharmacol 28: 233–236, 1974.

    Article  PubMed  CAS  Google Scholar 

  30. Ross SB, Ogren SO, Renyi AL: (Z)-Dimethylamino-l-(4-bromophenyl)-1-(3 pyridyl)propene (H102/09), a new selective inhibitor of neuronal 5-hydroxytryptamine uptake. Acta Pharmacol Toxicol 39: 152–166, 1976.

    Article  CAS  Google Scholar 

  31. Amit Z, Brown Z, Sutherland A, et al: Reduction in alcohol intake in humans as a function of treatment with zimelidine: Implications for treatment, in C.A. Naranjo and E.M. Sellers (eds): Research Advances in New Psychopharmacological Treatments for Alcoholism. Elsevier, Amsterdam, 1985, p 189.

    Google Scholar 

  32. Naranjo CA, Sellers EM, Roach CA, et al: Zimelidine-induced variations in alcohol intake by non-depressed heavy drinkers. Clin Pharmacol Ther 35: 374–381, 1984.

    Article  PubMed  CAS  Google Scholar 

  33. Naranjo CA, Sellers EM, Wu PH, et al: Moderation of ethanol drinking: Role of enhanced serotonergic neurotransmission, in Naranjo CA, Sellers EM (eds): Research Advances in New Psychopharmacological Treatments for Alcoholism. Elsevier, Amsterdam, 1985, p 171.

    Google Scholar 

  34. Amit Z, Sutherland EA, Gill K, et al: Zimelidine: A review of its effects on ethanol consumption. Neurosci Biobehav Rev 8: 35–54, 1984.

    Article  PubMed  CAS  Google Scholar 

  35. Rockman GE, Amit Z, Carr G, et al: Attenuation of ethanol intake by 5-hydroxytryptamine uptake blockade in laboratory rats. I. Involvement of brain 5-hydroxytryptamine in the mediation of the positive reinforcing properties of ethanol. Arch Int Pharmacodyn Ther 241: 245–259, 1979.

    PubMed  CAS  Google Scholar 

  36. Rockman GE, Amit Z, Brown ZW, et al: An investigation of the mechanisms of action of 5-hydroxytryptamine in the suppression of ethanol intake. Neuropharmacology 21: 341–347, 1982.

    Article  PubMed  CAS  Google Scholar 

  37. Rockman GE, Amit Z, Carr G, et al: Attenuation of ethanol intake by 5-hydroxytryptamine uptake blockade in laboratory rats. II. Possible interaction with brain norepinephrine. Arch Int Pharmacodyn Ther 241: 260–265, 1979.

    PubMed  CAS  Google Scholar 

  38. Daoust M, Chretien P, Moore N, et al: Isolation and striatal (3H)serotonin uptake: Role in the voluntary intake of ethanol by rats. Pharmacol Biochem Behav 22: 205–208, 1985.

    Article  PubMed  CAS  Google Scholar 

  39. Naranjo CA, Sellers EM, Sullivan JT, et al: The serotonin uptake inhibitor Citalopram attenuates ethanol intake. Clin Pharmacol Ther 41: 266–274, 1987.

    Article  PubMed  CAS  Google Scholar 

  40. Naranjo CA, Sellers EM (eds): Research Advances in New Psychopharmacological Treatments for Alcoholism. Amsterdam, Elsevier, 1985.

    Google Scholar 

  41. Buckholz NS: Neurobiology of tetrahydro-β-carbolines. Life Sci 27: 893–903, 1980.

    Article  Google Scholar 

  42. Davis VE, Walsh MJ: Alcohol amines and alkaloids. A possible biochemical basis for alcohol addiction. Science 167: 1005–1007, 1970.

    Article  PubMed  CAS  Google Scholar 

  43. Cohen G, Collins M: Alkaloids form catecholamines in adrenal tissue: Possible role in alcoholism. Science 167: 1749–1751, 1970.

    Article  PubMed  CAS  Google Scholar 

  44. Myers RD, Melchior CL: Differential actions on voluntary alcohol intake of tetrahydroisoqui-nolines or a β-carboline infused chronically in the ventricle of the rat. Pharmacol Biochem Behav 7: 381–392, 1977.

    Article  PubMed  CAS  Google Scholar 

  45. Tuomisto L, Airaksinen MM, Peura P, et al: Alcohol drinking in the rat: Increases following intracerebroventricular treatment with tetrahydro-β-carbolines. Pharmacol Biochem Behav 17: 831–836, 1982.

    Article  PubMed  CAS  Google Scholar 

  46. Rommelspacher H, Buchau C, Weiss J: Harman induces preference for ethanol in rats: Is the effect specific or ethanol? Pharmacol Biochem Behav 26: 749–755, 1987.

    Article  PubMed  CAS  Google Scholar 

  47. Bosin TR, Krogh SE and Zabik JE: Tetrahydro-β-carbolines in alcoholic beverages: Quantitation, neurochemical and ethanol drinking effects. Alc Alcohol 1: 323–327, 1987.

    CAS  Google Scholar 

  48. Baumgarten HG, Klemm HP, Lachenmoyer L, et al: Mode and mechanism of action of neurotoxic indoleamines: A review and a progress report. Ann NY Acad Sci 305: 3–24, 1978.

    Article  PubMed  CAS  Google Scholar 

  49. Myers RD, Melchior CL: Alcohol drinking in the rat after destruction of serotonergic and catecholaminergic neurons in the brain. Res Commun Chem Pathol Pharmacol 10: 363–377, 1975.

    PubMed  CAS  Google Scholar 

  50. Melchior CL, Myers RD: Genetic differences in ethanol drinking of the rat following injection of 6-OHDA, 5,6-DHT or 5,7-DHT into the cerebral ventricles. Pharmacol Biochem Behav 5: 63–72, 1976.

    Article  PubMed  CAS  Google Scholar 

  51. Richardson JS, Novakovski DM: Brain monoamines and free choice ethanol consumption in rats. Drug Alc Depend 3: 253–264, 1978.

    Article  CAS  Google Scholar 

  52. Ellison G, Daniel F, Zoraster R: Delayed increases in alcohol consumption occur in rat colonies but not in isolated rats after injections of monoamine neurotoxins. Exp Neurol 65: 608–615, 1979.

    Article  PubMed  CAS  Google Scholar 

  53. Zhukov VN, Varkov AI, Burov YV: Influence of destruction of brain 5HT system on alcohol intake at early times of experimental alcoholism in rats. Byull Eksp Biol Med (USSR) 99/5: 576–577, 1985.

    Article  CAS  Google Scholar 

  54. Hollway FA, Bird DC, McLean GA, et al: Effects of cortical, hypothalamic, and hippocampal lesions on chronic alcohol intake and preference in rats, in Galanter M (ed): Currents in Alcoholism, Vol. VII. New York, Grune and Stratton, 1980, p 123.

    Google Scholar 

  55. Ho AKS, Tsai CS, Chen RCA, et al: Experimental studies on alcoholism. I. Increase in alcohol preference by 5,6-dihydroxytryptamine and brain acetylcholine. Psychopharmacologia 40: 101–107, 1974.

    Article  PubMed  CAS  Google Scholar 

  56. Kiianmaa K: Alcohol intake in the rat after lowering brain 5-hydroxytryptamine content by electrolyte midbrain raphe lesions, 5,6-dihydroxytryptamine or parachlorophenylalanine. Med Biol 54: 203–209, 1976.

    PubMed  CAS  Google Scholar 

  57. Ahtee L, Eriksson K: 5-hydroxytryptamine and 5-hydroxyindoleacetic acid content in brain of rat strains selected for their ethanol intake. Physiol Behav 8: 123–126, 1972.

    Article  PubMed  CAS  Google Scholar 

  58. Cicero TJ, Hill SY: Ethanol self-selection in rats: A distinction between absolute and 95 percent ethanol. Physiol Behav 5: 787–791, 1970.

    Article  PubMed  CAS  Google Scholar 

  59. Veale WL, Myers RD: Decrease in ethanol intake in rats following administration of p-chloro-phenylalanine. Neuropharmacology 9: 317–326, 1970.

    Article  PubMed  CAS  Google Scholar 

  60. Nachman M, Lester D, Magnen JL: Alcohol aversion in the rat: Behavioral assessment of noxious drug effects. Science 168: 1244–1246, 1970.

    Article  PubMed  CAS  Google Scholar 

  61. Stein JM, Wayner MJ, Tillson HA: The effect of para-chlorophenylalanine on the intake of ethanol and saccharin solutions. Pharmacol Biochem Behav 6: 117–122, 1977.

    Article  PubMed  CAS  Google Scholar 

  62. Walters JK: Effects of PCPA on the consumption of alcohol, water and other solutions. Pharm Biochem Behav 6: 377–383, 1977.

    Article  CAS  Google Scholar 

  63. Hill, SY, Goldstein R: Effect of parachlorophenylalanine and stress on alcohol consumption by rats. Q J Stud Alcohol 35: 34–41, 1974.

    CAS  Google Scholar 

  64. Parker LF, Radow BL: Effects of parachlorophenylalanine on ethanol self-selection in the rat. Pharmacol Biochem Behav 4: 535–540, 1976.

    Article  PubMed  CAS  Google Scholar 

  65. Holman RB, Hoyland V, Shillito EE: The failure of p-chlorophenylalanine to affect voluntary alcohol consumption in rats. Br J Pharamcol 53: 299–304, 1975.

    Article  CAS  Google Scholar 

  66. Myers RD, Tytell M: Volitional consumption of flavored ethanol solution by rats: The effects of pCPA, and the absence of tolerance. Physiol Behav 8: 403–408, 1972.

    Article  PubMed  CAS  Google Scholar 

  67. Koe BK, Weissman A: p-Chlorophenylalanine: A specific depletor of brain serotonin. J Pharmacol 154: 499–507, 1966.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana, 47907, USA

    Joseph E. Zabik

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  1. New York University School of Medicine, New York, New York, USA

    Marc Galanter

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Zabik, J.E. (1989). Use of Serotonin-Active Drugs in Alcohol Preference Studies. In: Galanter, M. (eds) Recent Developments in Alcoholism. Recent Developments in Alcoholism, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1678-5_11

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  • DOI: https://doi.org/10.1007/978-1-4899-1678-5_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1680-8

  • Online ISBN: 978-1-4899-1678-5

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