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Morphogenesis of Flaviviruses

  • Chapter
Virally Infected Cells

Part of the book series: Subcellular Biochemistry ((SCBI,volume 15))

Abstract

The flaviviruses consist of about 70 viruses that include some important pathogens that are responsible for a number of serious diseases, such as yellow fever, dengue fever, and various encephalitides (Porterfield, 1980; Shope, 1980). They are transmitted to humans by arthropod vectors, i.e., mosquitoes and ticks (Chamberlain, 1980) and are also called arboviruses. The number of known flaviviruses will undoubtedly increase in the future as more viruses are isolated from various hosts and their vectors. Until recently, the flavivirus genus was included with three others, alphavirus, pestivirus, and rubivirus, as part of the Togaviridae family (Porterfield et al., 1978). With the accumulation of experimental data, it has become increasingly clear that flaviviruses have substantially different genomic organization and mechanisms of replication and gene expression from those of alphaviruses, the other major genus of the Togaviridae family. Therefore, the possibility that the two genera have diverged from the same ancestor is remote. Consequently, flaviviruses are now classified in their own family, Flaviviridae (Westaway et al., 1985).

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References

  • Bell, J. R., Kenney, R. M., Trent, D. W., Lenches, E. M., Dalgamo, L., and Strauss, J. H., 1985, Amino-terminal amino acid sequences of structural proteins of three flaviviruses, Virology 143:224–229.

    PubMed  CAS  Google Scholar 

  • Berger, E. G., Buddecke, E., Kamerling, J. P., Kobata, A., Paulson, J. C., and Vliegenthart, J. F. G., 1982, Structure, biosynthesis, and functions of glycoprotein glycans, Experientia 38:1129–1258.

    PubMed  CAS  Google Scholar 

  • Bhamarapravati, N., Yoksan, S., Chayaniyayothin, S., Angsubphakorn, S., and Bunyaratvej, A., 1987, Immunization with a live attenuated dengue-2 virus candidate vaccine (16681-PDK 53): clinical, immunological, and biological responses in adult volunteers, Bull. WHO 65:189–195.

    PubMed  CAS  Google Scholar 

  • Biedrzycka, A., Cauchi, M. R., Bartholomeuz, A., Gorman, J. J., and Wright, P. J., 1987, Characterization of protease cleavage sites involved in the formation of the envelope glycoprotein and three non-structural proteins of dengue virus type-2, New Guinea C strain, J. Gen. Virol. 68:1317–1326.

    PubMed  CAS  Google Scholar 

  • Blobel, G., and Dobberstein, B., 1975, Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma, J. Cell Biol. 67:835–851.

    PubMed  CAS  Google Scholar 

  • Boege, U., Heinz, F. X., Wengler, G., and Kunz, C., 1983, Amino acid compositions and aminoterminal sequences of the structural proteins of a flavivirus, European tick-borne encephalitis virus, Virology 126:651–657.

    PubMed  CAS  Google Scholar 

  • Boulton, R. W., and Westaway, E. G., 1972, Comparisons of togaviruses: Sindbis virus (group A) and Kunjin virus (group B), Virology 49:283–289.

    PubMed  CAS  Google Scholar 

  • Boulton, R. W., and Westaway, E. G., 1976, Replication of the flavivirus: Proteins, glycoproteins, and maturation associated with cell membranes, Virology 69:416–430.

    PubMed  CAS  Google Scholar 

  • Boulton, R. W., and Westaway, E. G., 1977, Togavirus RNA: Reversible effect of urea on genomes and absence of subgenomic viral RNA in Kunjin virus-infected cells, Arch. Virol. 55:201–208.

    PubMed  CAS  Google Scholar 

  • Brandt, W. E., Cardiff, R. D., and Russell, P. K., 1970, Dengue virions and antigens in brain and serum of infected mice, J. Virol. 6:500–506.

    PubMed  CAS  Google Scholar 

  • Brandt, W. E., McCown, J. M., Gentry, M. K., and Russell, P. K., 1982, Infection enhancement of dengue type 2 virus in the U-937 human monocyte cell line by antibodies to flavivirus crossreactive determinants, Infect. Immun. 36:1036–1041.

    PubMed  CAS  Google Scholar 

  • Briggs, M. S., and Gierasch, L. M., 1986, Molecular mechanisms of protein secretion: The role of the signal sequence, Adv. Protein Chem. 38:110–174.

    Google Scholar 

  • Brinton, M. A., 1982, Characterization of West Nile virus persistent infections in genetically resistant and susceptible mouse cells. I. Generation of defective nonplaquing virus particles, Virology 116:84–98.

    PubMed  CAS  Google Scholar 

  • Brinton, M. A., 1986, Replication of flaviviruses, in: The Togaviridae and Flaviviridae (S. Schlesinger and M. J. Schlesinger, eds.), pp. 327–374, Plenum, New York.

    Google Scholar 

  • Brown, D. T., 1980, The assembly of alphaviruses, in: The Togaviruses. Biology, Structure, Replication (R. W. Schlesinger, ed.), pp. 437–501, Academic, New York.

    Google Scholar 

  • Cardiff, R. D., and Lund, J. K., 1976, Distribution of dengue-2 antigens by electron immunocytochemistry, Infect. Immun. 13:1699–1709.

    PubMed  CAS  Google Scholar 

  • Cardiff, R. D., Dalrymple, J. M., and Russell, P. K., 1973a, RNA polymerase in group B arbovirus (dengue-2) infected cells, Arch. Ges. Virusforsch. 40:392–396.

    PubMed  CAS  Google Scholar 

  • Cardiff, R. D., Russ, S. B., Brandt, W. E., and Russell, P. K., 1973b, Cytological localization of dengue-2 antigens: An immunological study with ultrastructural correlation, Infect. Immun. 7:809–816.

    PubMed  CAS  Google Scholar 

  • Castle, E., Nowak, T., Leidner, U., Wengler, G., and Wengler, G., 1985, Sequence analysis of the viral core protein and the membrane-associated proteins VI and NV2 of the flavivirus West Nile virus and of the genome sequence for these proteins, Virology 145:227–236.

    PubMed  CAS  Google Scholar 

  • Castle, E., Leidner, U., Nowak, T., Wengler, G., and Wengler, G., 1986, Primary structure of the West Nile flavivirus genome region coding for all nonstructural proteins, Virology 149:10–26.

    PubMed  CAS  Google Scholar 

  • Catanzaro, P. J., Brandt, W. E., Hogrefe, W. R., and Russell, P. K., 1974, Detection of dengue cell-surface antigens by peroxidase-labeled antibodies and immune cytolysis, Infect. Immun. 10:381–388.

    PubMed  CAS  Google Scholar 

  • Chamberlain, R. W., 1980, Epidemiology of arthropod-borne togaviruses: the role of arthropods as hosts and vectors and of vertebrate hosts in normal transmission cycles, in: The Togaviruses. Biology, Structure, Replication (R. W. Schlesinger, ed.), pp. 175–227, Academic, New York.

    Google Scholar 

  • Chu, P. W. G., and Westaway, E. G., 1985, Replication strategy of Kunjin virus: Evidence for recycling role of replicative form RNA as a template in semiconservative and asymmetric replication, Virology 140:68–79.

    PubMed  CAS  Google Scholar 

  • Chu, P. W. G., and Westaway, E. G., 1987, Characterization of Kunjin virus RNA-dependent RNA polymerase: Reinitiation of synthesis in vitro, Virology 157:330–337.

    PubMed  CAS  Google Scholar 

  • Cleaves, G. R., and Dubin, D. T., 1979, Methylation status of intracellular dengue type 2 40S RNA, Virology 96:159–165.

    PubMed  CAS  Google Scholar 

  • Cleaves, G. R., Ryan, T. E., and Schlesinger, R. W., 1981, Identification and characterization of type 2 dengue virus replication intermediate and replicative form RNAs, Virology 111:73–85.

    PubMed  CAS  Google Scholar 

  • Clegg, J. C. S., 1982, Glycoprotein detection in nitrocellulose transfers of electrophoretically separated protein mixtures using concanavalin A and peroxidase: Application to arenavirus and flavivirus proteins, Anal. Biochem. 127:389–394.

    PubMed  CAS  Google Scholar 

  • Dalgarno, L., Trent, D. W., Strauss, J. H., and Rice, C. M., 1985, Partial nucleotide sequence of the Murray Valley encephalitis virus genome. Comparison of the encoded polypeptides with yellow fever virus structural and nonstructural proteins, J. Mol. Biol. 187:309–323.

    Google Scholar 

  • Daughaday, C. C., Brandt, W. E., McCown, J. M., and Russell, P. K., 1981, Evidence for two mechanisms of dengue virus infection of adherent human monocytes: Trypsin-sensitive virus receptors and trypsin-resistant immune complex receptors, Infect. Immun. 32:469–473.

    PubMed  CAS  Google Scholar 

  • Della Porta, A. J., and Westaway, E. G., 1977, Immune response in rabbits to virion and nonvirion antigens of the Flavivirus Kunjin, Infect. Immun. 15:874–882.

    PubMed  CAS  Google Scholar 

  • DeMadrid, A. T., and Porterfield, J. S., 1974, The flaviviruses (group B arboviruses): A cross-neutralization study, J. Gen. Virol. 23:91–96.

    CAS  Google Scholar 

  • Deubel, V., Kinney, R. M., and Trent, D. W., 1986, Nucleotide sequence and deduced amino acid, sequence of the structural proteins of dengue type 2 virus, Jamaica genotype, Virology 155:365–377.

    PubMed  CAS  Google Scholar 

  • Eckels, K. H., Brandt, W. E., Harrison, V. R., McCown, J. M., and Russell, P. K., 1976, Isolation of a temperature-sensitive dengue-2 virus under conditions suitable for vaccine development, Infect. Immun. 14:1221–1227.

    PubMed  CAS  Google Scholar 

  • Eckels, K. H., Harrison, V. R., Summers, P. L., and Russell, P. K., 1980, Dengue-2 vaccine: Preparation from a small plaque virus clone, Infect. Immun. 27:175–180.

    PubMed  CAS  Google Scholar 

  • Filshie, B. K., and Rehacek, J., 1968, Studies of the morphology of Murray Valley encephalitis and Japanese encephalitis viruses growing in cultured mosquito cells, Virology 34:435–443.

    PubMed  CAS  Google Scholar 

  • Ferenci, T., and Silhavy, T. J., 1987, Minireview. Sequence information required for protein translocation from the cytoplasm, J. Bacteriol. 169:5339–5342.

    PubMed  CAS  Google Scholar 

  • Gollins, S. W., and Porterfield, J. S., 1985, Flavivirus infection enhancement in macrophages: An electron microscopic study of viral cellular entry, J. Gen. Virol. 66:1969–1982.

    PubMed  Google Scholar 

  • Hahn, Y. S., Galler, R., Hunkapiller, T., Dalrymple, J. M., Strauss, J. H., and Strauss, E. G., 1988, Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses, Virology 162:167–180.

    PubMed  CAS  Google Scholar 

  • Halstead, S. B., 1979, In vitro enhancement of dengue infection with passively transferred antibody, J. Infect. Dis. 140:527–533.

    PubMed  CAS  Google Scholar 

  • Halstead, S. B., 1988, Pathogenesis of dengue: Challenges to molecular biology, Science 239:476–481.

    PubMed  CAS  Google Scholar 

  • Halstead, S. B., Chow, J. S., and Marchette, N. J., 1973, Immunological enhancement of dengue virus replication, Nature (Lond.) 243:24–26.

    CAS  Google Scholar 

  • Halstead, S. B., O’Rourke, E. J., and Allison, A. C., 1977, Dengue viruses and mononuclear phagocytes. II. Identity of blood and tissue leukocytes supporting in vitro infection, J. Exp. Med. 146:218–229.

    PubMed  CAS  Google Scholar 

  • Harrison, V. R., Eckels, K. H., Sagartz, J. W., and Russell, P. K., 1977, Virulence and immunogenicity of a temperature-sensitive dengue-2 virus in lower primates. Infect. Immun. 18:151–156.

    PubMed  CAS  Google Scholar 

  • Hase, T., Summers, P. L., Eckels, K. H., and Baze, W. B., 1987a, An electron and immunoelectron microscopic study of dengue-2 virus infection of cultured mosquito cells: Maturation events, Arch. Virol. 92:273–291.

    PubMed  CAS  Google Scholar 

  • Hase, T., Summers, P. L., Eckels, K. H., and Baze, W. B., 1987b, Maturation process of Japanese encephalitis virus in cultured mosquito cells in vitro and mouse brain cells in vivo, Arch. Virol. 96:135–151.

    PubMed  CAS  Google Scholar 

  • Hase, T., Summers, P. L., and Eckels, K. H., 1989, Flavivirus entry into cultured mosquito cells and human peripheral blood monocytes, Arch. Virol., in press.

    Google Scholar 

  • Heinz, F. X., Tuma, W., and Kunz, C., 1981, Antigenic and immunogenic properties of defined physical forms of tickborne encephalitis virus structural proteins, Infect. Immun. 33:250–257.

    PubMed  CAS  Google Scholar 

  • Holland, J., Spindler, K., Horoddyski, F., Grabau, E., Nichol, S., and Van de Pol, S., 1982, Rapid evolution of RNA genomes, Science 215:1577–1585.

    PubMed  CAS  Google Scholar 

  • Hong, S. S., and Ng, M. L., 1987, Involvement of microtubules in Kunjin virus replication, Arch. Virol. 97:115–121.

    PubMed  CAS  Google Scholar 

  • Igarashi, A., 1979, Characteristics of A. albopictus cells persistently infected with dengue viruses, Nature (Lond.) 280:690–691.

    CAS  Google Scholar 

  • Igarashi, A., Fukunaga, T., and Fukai, I., 1964, Sedimentation characteristics of Japanese encephalitis virus ribonucleic acid, Biken J. 7:111–119.

    PubMed  CAS  Google Scholar 

  • Kaiser, CA., Preuss, D., Grisafi, P., and Botstein, D., 1987, Many random sequences functionally replace the secretion signal sequence of yeast invertase, Science 235:312–317.

    PubMed  CAS  Google Scholar 

  • Kimura, T., Gollins, S. W., and Porterfield, J. S., 1986, The effect of pH on the early infection of West Nile virus with P388D1 cells, J. Gen. Virol. 67:2423–2433.

    PubMed  CAS  Google Scholar 

  • Kitano, T., Suzuki, K., and Yamaguchi, T., 1974, Morphological, chemical, and biological characterization of Japanese encephalitis virus virion and its hemagglutinin, J. Virol. 14:631–639.

    PubMed  CAS  Google Scholar 

  • Kos, K. A., Osborne, B. A., and Goldsby, R. A., 1975, Inhibition of group B arbovirus antigen production and replication in cells enucleated with cytochalasin B, J. Virol. 15:913–917.

    PubMed  CAS  Google Scholar 

  • Leary, K., and Blair, C. D., 1980, Sequential events in the morphogenesis of Japanese encephalitis virus, J. Ultrastruct. Res. 72:123–129.

    PubMed  CAS  Google Scholar 

  • Lobigs, M., Dalgarno, L., Schlesinger, J. J., and Weir, R. C., 1987, Location of a neutralization determinant in the E protein of yellow fever virus (17D vaccine strain), Virology 161:474–478.

    PubMed  CAS  Google Scholar 

  • Matsumura, T., Stoller, V., and Schlesinger, R. W., 1971, Studies on the nature of dengue viruses. V. Structure and development of dengue virus in Vero cells, Virology 46:344–355.

    PubMed  CAS  Google Scholar 

  • Mackow, E., Makino, Y., Zhao, B., Zhang, Y. M., Markoff, L., Buckler-White, A., Guiler, M., Chanock, R., and Lai, C. J., 1987, The nucleotide sequence of dengue type 4 virus: Analysis of gene coding for nonstructural proteins, Virology 159:217–228.

    PubMed  CAS  Google Scholar 

  • Mason, P. W., McAda, P. C., Dalrymple, J. M., Fournier, M. J., and Mason, T. R., 1987, Expression of Japanese encephalitis virus antigens in Escherichia coli, Virology 158:361–372.

    PubMed  CAS  Google Scholar 

  • Mason, P. W., McAda, P. C., Mason, T. L., and Fournier, M. J., 1987, Sequence of the dengue-1 virus genome in the region encoding the three structural proteins and the major nonstructural protein NS1, Virology 161:262–267.

    PubMed  CAS  Google Scholar 

  • Mayer, V., 1963, Two variants of tick-borne encephalitis showing different plaque morphology, Virology 20:372–390.

    PubMed  CAS  Google Scholar 

  • McAda, P. C., Mason, P. W., Schmaljohn, C. S., Dalrymple, J. M., Mason, T. L., and Fournier, M. J., 1987, Partial nucleotide sequence of the Japanese encephalitis virus genome, Virology 158:348–360.

    PubMed  CAS  Google Scholar 

  • Monckton, R. P., and Westaway, E. G., 1982, Restricted translation of the genome of the Flavivirus Kunjin in vitro, J. Gen. Virol. 63:227–232.

    PubMed  CAS  Google Scholar 

  • Murphy, F. A., 1980, Togavirus morphology and morphogenesis, in: The Togaviruses. Biology, Structure, Replication (R. W. Schlesinger, ed.), pp. 241–315, Academic, New York.

    Google Scholar 

  • Murphy, F. A., Harrison, A. K., Gary, G. W., Jr., Whitfield, S. G., and Forrester, F. G., 1968, St. Louis encephalitis virus infection of mice. Electron microscopic studies of central nervous system, Lab. Invest. 19:652–662.

    PubMed  CAS  Google Scholar 

  • Naeve, C. W., and Trent, D. W., 1978, Identification of St. Louis encephalitis virus mRNA, J. Virol. 25:535–545.

    PubMed  CAS  Google Scholar 

  • Ng, M. L., 1987, Ultrastructural studies of Kunjin virus-infected Aedes albopictus cells, J. Gen. Virol. 68:577–582.

    PubMed  Google Scholar 

  • Ng, M. L., Pedersen, J. S., Toh, B. H., and Westaway, E. G., 1983, Immunofluorescent sites in Vero cells infected with the flavivirus Kunjin, Arch. Virol. 78:177–190.

    PubMed  CAS  Google Scholar 

  • Nowak, T., and Wengler, G., 1987, Analysis of disulfides present in the membrane proteins of the West Nile flavivirus, Virology 156:127–137.

    PubMed  CAS  Google Scholar 

  • Ota, E., 1965, Electron microscopic study of the development of Japanese encephalitis virus in porcine kidney stable (PS) cells, Virology 25:372–378.

    PubMed  CAS  Google Scholar 

  • Paul, S. D., 1966, Some biological properties of two variants of Kyasanur Forest disease virus, Indian J. Med. Res. 54:419–424.

    Google Scholar 

  • Peiris, J. S. M., and Porterfield, J. S., 1979, Antibody-mediated enhancement of flavivirus replication in macrophage cell lines, Nature (Lond.) 282:509–511.

    CAS  Google Scholar 

  • Porterfield, J. S., 1980, Antigenic characteristics and classification of Togaviridae, in: The Togaviruses. Biology, Structure, Replication (R. W. Schlesinger, ed.), pp. 13–46, Academic, New York.

    Google Scholar 

  • Porterfield, J. S., Casals, J., Chumakov, M. P., Gaidamovich, S. Y., Hannoun, C., Holmes, I. H., Horzinek, M. C., Mussgay, M., Oken-Blom, N., Russell, P. K., and Trent, D. W., 1978, Togaviridae, Intervirology 9:129–148.

    PubMed  CAS  Google Scholar 

  • Qureshi, A. A., and Trent, D. W., 1972, Saint Louis encephalitis viral ribonucleic acid replication complex, J. Virol. 9:565–573.

    PubMed  CAS  Google Scholar 

  • Rice, C. M., Lenches, E. M., Eddy, S. R., Shin, S. J., Sheets, R. L., and Strauss, J. H., 1985, Nucleotide sequence of yellow fever virus: Implications for flavivirus gene expression and evolution, Science 229:726–733.

    PubMed  CAS  Google Scholar 

  • Rice, C. M., Albersold, R., Teplow, D. B., Pata, J., Bell, J. R., Vomdam, V., Trent, D. W., Brandriss, M. W., Schlesinger, J. J., and Strauss, J. H., 1986a, Partial N-terminal amino acid sequences of three non-structural proteins of two flaviviruses, Virology 151:1–9.

    PubMed  CAS  Google Scholar 

  • Rice, C. M., Strauss, E. C., and Strauss, J. H., 1986b, Structure of the flavivirus genome, in: The Togaviridae and Flaviviridae (S. Schlesinger and M. J. Schlesinger, ed.), pp. 279–326, Plenum, New York.

    Google Scholar 

  • Roizman, B., 1985, Multiplication of viruses: An overview, in: Virology (B. N. Fields, D. M. Knipe, R. M. Chanock, J. L. Melnick, B. Roizman, and R. E. Shope, ed.), pp. 69–75, Raven, New York.

    Google Scholar 

  • Russell, P. K., Chiewsilp, D., and Brandt, W. E., 1970, Immunoprecipitation analysis of soluble complement-fixing antigens of dengue viruses, J. Immunol. 105:838–845.

    PubMed  CAS  Google Scholar 

  • Russell, P. K., Brandt, W. E., and Dalrymple, J. M., 1980, Chemical and antigenic structure of flaviviruses, in: The Togaviruses. Biology, Structure, Replication (R. W. Schlesinger, ed.), Academic, New York.

    Google Scholar 

  • Schlesinger, J. J., Brandriss, M. W., and Monath, T. P., 1983, Monoclonal antibodies distinguish between wild and vaccine strains of yellow fever virus by neutralization, hemagglutination inhibition, and immune precipitation of the virus envelope protein, Virology 125:8–17.

    PubMed  CAS  Google Scholar 

  • Schlesinger, J. J., Brandriss, M. W., and Walsh, E. E., 1985, Protection against 17D yellow fever encephalitis in mice by passive transfer of monoclonal antibodies to the nonstructural glycoprotein gp48 and by active immunization with gp48, J. Immunol. 135:2805–2809.

    PubMed  CAS  Google Scholar 

  • Schlesinger, J. J., Brandriss, M. W., Cropp, C. B., and Monath, T. P., 1986, Protection against yellow fever in monkeys by immunization with yellow fever virus nonstructural protein NS1, J. Virol. 60:1153–1155.

    PubMed  CAS  Google Scholar 

  • Schlesinger, J. J., Brandriss, M. W., and Walsh, E. E., 1987, Protection of mice against dengue 2 virus encephalitis by immunization with the dengue 2 virus non-structural glycoprotein NS1, J. Gen. Virol. 68:853–857.

    PubMed  CAS  Google Scholar 

  • Schlesinger, R. W., 1980, Virus-host interactions in natural and experimental infections with alphaviruses and flaviviruses, in: The Togaviruses. Biology, Structure, Replication (R. W. Schlesinger, ed.), pp. 83–106, Academic, New York.

    Google Scholar 

  • Shapiro, D., Brandt, W. E., Cardiff, R. D., and Russell, P. K., 1971, The proteins of Japanese encephalitis virus, Virology 44:108–124.

    PubMed  CAS  Google Scholar 

  • Shapiro, D., Brandt, W. E., and Russell, P. K., 1972, Change involving a viral membrane glycoprotein during morphogenesis of group B arboviruses, Virology 50:906–911.

    PubMed  CAS  Google Scholar 

  • Shapiro, D., Kos, K. A., and Russell, P. K., 1973, Japanese encephalitis virus glycoproteins, Virology 56:88–94.

    PubMed  CAS  Google Scholar 

  • Shope, R. E., 1980, Medical significance of togaviruses: An overview of diseases caused by togaviruses in man and in domestic and wild vertebrate animals, in: The Togaviruses. Biology, Structure, Replication (R. W. Schlesinger, ed.), pp. 47–82, Academic, New York.

    Google Scholar 

  • Simons, K., Garoff, H., and Helenius, H., 1980, Alphavirus proteins, in: The Togaviruses. Biology, Structure, Replication (R. W. Schlesinger, ed.), pp. 317–333, Academic Press, New York.

    Google Scholar 

  • Sriurairatna, S., Bhamarapravati, N., and Phalavadhtana, O., 1973, Dengue virus infection of mice: Morphology and morphogenesis of dengue type-2 virus in suckling mouse neurons, Infect. Immun. 8:1017–1028.

    PubMed  CAS  Google Scholar 

  • Smith, G. W., and Wright, P. J., 1985, Synthesis of proteins and glycoproteins in dengue type 2 virus-infected Vero and Aedes albopictus cells, J. Gen. Virol. 66:559–571.

    PubMed  CAS  Google Scholar 

  • Stohlman, S. A., Wisseman, C. L. Jr., Eyler, O. R., and Silverman, D. J., 1975, Dengue virusinduced modification of host cell membranes, J. Virol. 16:1017–1026.

    PubMed  CAS  Google Scholar 

  • Stohlman, S. A., Eyler, O. R., and Wissemann, C. L., Jr., 1976, Isolation of the dengue virus envelope glycoprotein from membranes of infected cells by concanavalin A affinity chromatography, J. Virol. 18:132–140.

    PubMed  CAS  Google Scholar 

  • Stollar, V., 1969, Studies on the nature of dengue viruses. IV. The structural proteins of type 2 dengue virus, Virology 39:426–438.

    PubMed  CAS  Google Scholar 

  • Stollar, V., Stevens, T. M., and Schlesinger, R. W., 1966, Studies on the nature of dengue viruses. II. Characterization of viral RNA and effects of inhibitors of RNA synthesis, Virology 30:303–312.

    PubMed  CAS  Google Scholar 

  • Stollar, V., Schlesinger, R. W., and Stevens, T. M., 1967, Studies on the nature of dengue viruses. III. RNA synthesis in cells infected with type-2 dengue virus, Virology 33:650–658.

    PubMed  CAS  Google Scholar 

  • Sumiyoshi, H., Mori, C., Fuke, I., Morita, K., Kuhara, S., Kondou, J., Kikuchi, Y., Nagamatu, H., and Igarashi, A., 1987, Complete nucleotide sequence of the Japanese encephalitis virus genome RNA, Virology 161:497–510.

    PubMed  CAS  Google Scholar 

  • Svitkin, Y. V., Ugarova, T. Y., Chernovskaya, T. V., Lyapustin, V. N., Lashkevich, V. A., and Agol, V. I., 1981, Translation of tick-borne encephalitis virus (flavivirus) genome in vitro: Synthesis of two structural polypeptides, Virology 110:26–34.

    PubMed  CAS  Google Scholar 

  • Svitkin, Y. V., Lyapustin, V. N., Lashkevich, V. A., and Agol, V. I., 1984, Differences between translation products of tick-borne encephalitis virus RNA in cell-free system from Krebs-2 cells and rabbit reticulocytes: Involvement of membranes in the processing of nascent precursors of flavivirus structural proteins, Virology 135:536–541.

    PubMed  CAS  Google Scholar 

  • Takegami, T., Miyamoto, H., Nakamoto, H., and Yasui, K., 1982, Biological activities of the structural proteins of Japanese encephalitis virus, Acta Virol. 26:312–320.

    PubMed  CAS  Google Scholar 

  • Takehara, M., 1971, Comparative studies on nucleic acid synthesis and virus-induced RNA polymerase activity in mammalian cells infected with certain arboviruses, Arch. Ges. Virusforsch. 34:266–277.

    PubMed  CAS  Google Scholar 

  • Takeda, H., Oya, A., Hashimoto, K., Yasuda, T., and Yamada, M., 1978, Association of virus specific replicative ribonucleic acid with nuclear membrane in chick embryo cells infected with Japanese encephalitis virus, J. Gen. Virol. 38:281–291.

    PubMed  CAS  Google Scholar 

  • Theofilopoulos, A. N., Brandt, W. E., Russell, P. K., and Dixon, F. T., 1976, Replication of dengue-2 virus in cultured human lymphoblastoid cells and subpopulations of human peripheral leukocytes, J. Immunol. 117:953–961.

    PubMed  CAS  Google Scholar 

  • Trent, D. W., 1977, Antigenic characterization of flavivirus structural proteins separated by isoelectric focusing, J. Virol 22:608–618.

    PubMed  CAS  Google Scholar 

  • Trent, D. W., Swensen, C. C., and Qureshi, A. A., 1969, Synthesis of Saint Louis encephalitis virus ribonucleic acid in BHK-21/13 cells, J. Virol. 3:385–394.

    PubMed  CAS  Google Scholar 

  • Trent, D. W., Kinney, R. M., Johnson, B. J., Vorndam, A. V., Grant, J. A., Deubel, V., Rice, C. M., and Hahn, C., 1987, Partial nucleotide sequence of St. Louis encephalitis virus RNA: Structural proteins, NS1, ns2a, and ns2b, Virology 156:293–304.

    PubMed  CAS  Google Scholar 

  • Wengler, G., 1987, The mode of assembly of alphavirus cores implies a mechanism for the disassembly of the cores in the early stages of infection. Brief review, Arch. Virol. 94:1–14.

    PubMed  CAS  Google Scholar 

  • Wengler, G., and Wengler, G., 1981, Terminal sequences of the genome and replicative form RNA of the flavivirus West Nile virus: Absence of poly (A) and possible role in RNA replication, Virology 113:544–555.

    PubMed  CAS  Google Scholar 

  • Wengler, G., Wengler, G., and Gross, H. J., 1978, Studies on virus-specific nucleic acids synthesized in vertebrate and mosquito cells infected with flaviviruses, Virology 89:423–437.

    PubMed  CAS  Google Scholar 

  • Wengler, G., Beato, M., and Wengler, G., 1979, In vitro translation of 42S virus-specific RNA from cells infected with the flavivirus West Nile virus, Virology 96:516–529.

    PubMed  CAS  Google Scholar 

  • Wengler, G., Castle, E., Leidner, U., Nowak, T., and Wengler, G., 1985, Sequence analysis of the membrane protein V3 of the flavivirus West Nile virus and of its gene, Virology 147:264–274.

    PubMed  CAS  Google Scholar 

  • Wengler, G., Wengler, G., Nowak, T., and Wahn, K., 1987, Analysis of the influence of proteolytic cleavage on the structural organization of the surface of the West Nile flavivirus leads to the isolation of a protease-resistant E protein oligomer from the viral surface, Virology 160:210–219.

    PubMed  CAS  Google Scholar 

  • Westaway, E. G., 1975, The proteins of Murray Valley encephalitis virus, J. Gen. Virol. 27:283–293.

    Google Scholar 

  • Westaway, E. G., 1980, Replication of flaviviruses, in: The Togaviruses. Biology, Structure, Replication (R. W. Schlesinger, ed.), pp. 531–581, Academic, New York.

    Google Scholar 

  • Westaway, E. G., and Goodman, M. R., 1987, Variation in distribution of the three flavivirus-specified glycoproteins detected by immunofluorescence in infected Vero cells, Arch. Virol. 94:215–228.

    PubMed  CAS  Google Scholar 

  • Westaway, E. G., and Reedman, B. M., 1969, Proteins of the group B arbovirus Kunjin, J. Virol. 4:688–693.

    PubMed  CAS  Google Scholar 

  • Westaway, E. G., Brinton, M. A., Gaidamovich, S. Y., Horznek, M. C., Igarashi, A., Kääriäinen, L., Lvov, D. K., Porterfield, J. S., Russell, P. K., and Trent, D. W., 1985, Flaviviridae, Intervirology 24:183–192.

    PubMed  CAS  Google Scholar 

  • Wickner, W. T., and Lodish, L. M., 1985, Multiple mechanisms of protein insertion into and across membranes, Science 230:400–407.

    PubMed  CAS  Google Scholar 

  • Winkler, G., Heinz, F. X., and Kunz, C., 1987, Studies on the glycosylation of flavivirus E proteins and the role of carbohydrate in antigenic structure, Virology 159:237–243.

    PubMed  CAS  Google Scholar 

  • Wirth, D. F., Katz, F., Small, B., and Lodish, H. F., 1977, How a single Sindbis virus mRNA directs the synthesis of one soluble protein and two integral membrane glycoproteins, Cell 10:253–263.

    PubMed  CAS  Google Scholar 

  • Wright, P. J., 1982, Envelope protein of the flavivirus Kunjin is apparently not glycosylated, J. Gen. Virol. 59:29–38.

    PubMed  CAS  Google Scholar 

  • Wright, P. J., Warr, H. M., and Westaway, E.G., 1981, Synthesis of glycoproteins in cells infected by the Flavivirus Kunjin, Virology 109:418–427.

    PubMed  CAS  Google Scholar 

  • Zebovitz, E., Leong, J. K. L., and Doughty, S. C., 1972, Japanese encephalitis virus replication. A procedure for the selective isolation and characterization of viral RNA species, Arch. Ges. Virusforsch. 38:319–327.

    PubMed  CAS  Google Scholar 

  • Zebovitz, E., Leong, J. K. L., and Doughty, S. C., 1974, Involvement of the host cell nuclear envelope membranes in the replication of Japanese encephalitis virus, Infect. Immun. 10:204–211.

    PubMed  CAS  Google Scholar 

  • Zhao, B., Mackow, E., Buckler-White, A., Markoff, L., Chanock, R. M., Lai, C. J., and Makino, Y., 1986, Cloning full-length dengue type 4 viral DNA sequences: Analysis of genes coding for structural proteins, Virology 155:77–88.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ultrastructural Studies, Walter Reed Army Institute of Research, Washington, D.C., 20307, USA

    Tatsuo Hase

  2. Department of Biologics Research, Walter Reed Army Institute of Research, Washington, D.C., 20307, USA

    Peter L. Summers & Kenneth H. Eckels

  3. Department of Viral Diseases, Walter Reed Army Institute of Research, Washington, D.C., 20307, USA

    Joseph R. Putnak

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  1. Tatsuo Hase
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  2. Peter L. Summers
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  3. Kenneth H. Eckels
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  4. Joseph R. Putnak
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Editors and Affiliations

  1. North East Thames Regional Transfusion Centre, Brentwood, Essex, England

    J. R. Harris

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© 1989 Springer Science+Business Media New York

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Hase, T., Summers, P.L., Eckels, K.H., Putnak, J.R. (1989). Morphogenesis of Flaviviruses. In: Harris, J.R. (eds) Virally Infected Cells. Subcellular Biochemistry, vol 15. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1675-4_9

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  • DOI: https://doi.org/10.1007/978-1-4899-1675-4_9

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