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Detection of Viral Antigens and Antibodies

Enzyme Immunoassays
Chapter
Part of the Subcellular Biochemistry book series (SCBI, volume 15)

Abstract

Serological techniques have been the most widely used means of diagnosing viral diseases for years, but several of their shortcomings have shifted the emphasis toward the direct detection of antigens. Nevertheless, serological testing is still useful if it is impractical or impossible to demonstrate the presence of a viral antigen, e.g., measles virus, togavirus, rubella virus, and Epstein-Barr virus (EBV). Moreover, serological approaches are important in distinguishing between serotypes or isolates. Developments in the design of enzyme immunoassays (EIA) and the production of monoclonal antibodies have permitted the development of techniques that have a specificity approaching or surpassing that required for clinical applications but that do not suffer from the serious drawbacks of classic methods.

Keywords

Respiratory Syncytial Virus Plant Virus Viral Antigen Rabies Virus Measle Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media New York 1989

Authors and Affiliations

  1. 1.Faculty of MedicineUniversity of Montreal and Hospital Hôtel Dieu de MontréalMontrealCanada
  2. 2.Viral Pathogenesis Research Unit, Department of Medical Microbiology and Infectious Diseases, Faculty of MedicineUniversity of AlbertaEdmontonCanada
  3. 3.Department of Veterinary Microbiology and the Veterinary Infectious Disease OrganizationUniversity of SaskatchewanSaskatoonCanada
  4. 4.Institute of Molecular and Cellular BiologyStrasbourgFrance

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