Investigational Approaches for Studying the Structures and Biological Functions of Myeloid Antimicrobial Peptides

  • Michael E. Selsted
Part of the Genetic Engineering: Principles and Methods book series (GEPM, volume 15)


Macrophages and neutrophils are phagocytic leukocytes of myeloid lineage, arising from hematopoietic precursors in the bone marrow. Neutrophils are short-lived cells which are terminally differentiated as they enter the circulation, whereas macrophages derive from circulating monocytes which mature into specialized cells in various tissues including lung, liver and skin. The phagocytic and microbicidal functions of neutrophils and macrophages provide an essential component of the host’s defense against colonization by a diverse spectrum of potential pathogens.


Antimicrobial Peptide Solid Phase Peptide Synthesis Crude Peptide Virucidal Activity Arginine Side Chain 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Michael E. Selsted
    • 1
  1. 1.Departments of Pathology and Microbiology and Molecular Genetics, College of MedicineUniversity of CaliforniaIrvineUSA

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