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Hypothalamic-Pituitary Function during Alcohol Exposure and Withdrawal and Cocaine Exposure

  • Jeffery N. Wilkins
  • David A. Gorelick
  • Koonlawee Nademanee
  • Anna Taylor
  • David S. Herzberg
Part of the Recent Developments in Alcoholism book series (RDIA, volume 10)

Abstract

This chapter examines the neuroendocrine effects of acute exposure to and withdrawal from alcohol and cocaine, with special emphasis on the hypothalamic-pituitary-adrenal (HPA) axis. We present the results from two preliminary controlled inpatient studies that document HPA dysfunction during acute exposure to alcohol and cocaine and during withdrawal from alcohol. We discuss the methodological approach of these studies in comparison to related attempts in the literature to use measures of thyroid and prolactin regulation to predict risk of relapse to alcohol and cocaine use, respectively. Our data and the results of related studies are presented in the context of a proposed index of HPA axis dysfunction that may provide a useful clinical measure of susceptibility to relapse during protracted abstinence from alcohol or cocaine.

Keywords

Cortisol Level Cortisol Response Alcohol Exposure Alcohol Withdrawal Cocaine Dependence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Jeffery N. Wilkins
    • 1
  • David A. Gorelick
    • 2
  • Koonlawee Nademanee
    • 3
  • Anna Taylor
    • 4
  • David S. Herzberg
    • 5
  1. 1.West Los Angeles Veterans Administration Medical Center, Brentwood DivisionSubstance Abuse ServiceLos AngelesUSA
  2. 2.Treatment and Early Intervention Branch, Addiction Research Center, National Institute on Drug Abuse, and Department of PsychiatryUniversity of Maryland School of MedicineBaltimoreUSA
  3. 3.Department of CardiologyDenver General HospitalDenverUSA
  4. 4.Department of Anatomy and Cell BiologyUCLA School of MedicineLos AngelesUSA
  5. 5.West Los Angeles Veterans Administration Medical Center, Brentwood DivisionResearch ServiceLos AngelesUSA

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